MUTANTS FC WITH ENHANCED FUNCTIONAL ACTIVITY

Abstract

Fc MUTANTS WITH ENHANCED FUNCTIONAL ACTIVITY The present invention relates to a variant of a parent polypeptide comprising an Fc fragment, said variant having an increased affinity for at least one of the Fc fragment receptors (FcR) selected from FcγRIIIa (CD16a), FcγRIIa (CD32a), and FcγRIIb (CD32b) compared to that of the parent polypeptide, characterized in that it comprises at least one mutation selected from V240H, V240I, V240M, V240N, V240S, F241H, F241Y, L242A, L242F, L242G, L242H, L242I, L242K, L242P, L242S, L242T, L242V, F243L, F243S, E258G, E258I, E258R, E258M, E258Q, E258Y, V259C, V259I, V259L, T260A, T260H, T260I, T260M, T260N, T260R, T260S, T260W, V262A, V262S, V263T, V264L, V264S, V264T, V266L, V266M, S267A, S267Q, S267V, K290D, K290E, K290G, K290H, K290L, K290N, K290Q, K290R, K290S, K290Y, P291G, P291Q, P291R, R292I, R292L, E293A, E293D, E293G, E293M, E293Q, E293S, E293T, E294A, E294G, E294P, E294Q, E294R, E294T, E294V, Q295I, Q295M, Y296H, Y296W, S298A, S298R, Y300I, Y300V, Y300W, R301A, R301M, R301P, R301S, V302A, V302F, V302L, V302M, V302R, V302S, V303S, V303Y, S304T, V305A, V305F, V305I, V305L, V305R and V305S of said fragment Fc, the numbering being that of the EU index or equivalent in Kabat.

Inventors

MONNET CÉLINE

Assignees

LAB FRANCAIS DU FRACTIONNEMENT

Dates

Publication Date: 20260501
Application Date: 20160706
Priority Date: 20160706