JP-2020513417-A5 -

Dates

Publication Date

20221227

Application Date

20171117

Description

Internal conversion of carotenoids: A. Conversion of administered 9CBC to 9CDHBC in vitro in human oligodendrocyte cell lines. A peak with a retention time of 25.1 minutes is present after 9CDHBC treatmentand is present at a lower level after 9CBC treatment. B. No conversion of ATBC to 9CBC or 9CDHBC in vitro in human oligodendrocyte cell lines. ATBC elutes at 27.2 minutes (detectable at 411 nm with a UV max of 450 nm) and is present at a very high level after ATBC treatment (second figure from the top in the right panel). 9CBC is present as a major shoulder peak after 9CBC treatment but is not detected after CTRL or alternative treatment.