JP-2021521142-A5 -

Dates

Publication Date

20230519

Application Date

20190409

Description

[6] Compounds selected from the group consisting of the following: 5-Chloro-2-methyl-N-((1r,4r)-4-((2-oxo-3-phenyl-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)nicotinamide; N-((1r,4r)-4-((3-benzyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-5-chloro-2-methylnicotinamide; 5-Chloro-2-methyl-N -(( (1r,4r)-4-((2-oxo-3-((tetrahydro-2H-pyran-4-yl)methyl ) -2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)nicotinamide; 5-Chloro-2-methyl-N-((1r,4r)-4-((3-(3-(methylcarbamoyl)benzyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)nicotinamide; 5-Chloro-2-methyl-N-((1r,4r)-4-((2-oxo-3-(2-oxo-2-phenylethyl)-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)nicotinamide; 5-Chloro-2-methyl-N -(( (1r,4r)-4-((2-oxo-3-(pyridine-2- ylmethyl) -2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)nicotinamide; 5-Chloro-2-methyl-N-((1r,4r)-4-((2-oxo-3-(pyridine-3- ylmethyl) -2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)nicotinamide; 5-Chloro-2-methyl-N -(( (1r,4r)-4-((2-oxo-3-(pyridine-4- ylmethyl) -2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)nicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(2-(4-methoxyphenyl)-2-oxoethyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(2-(2-methoxyphenyl)-2-oxoethyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(2-(hydroxymethyl)benzyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(2-(2,4-difluorophenyl)-2-oxoethyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(2-(4-cyanophenyl)-2-oxoethyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-2-methyl-N-((1r,4r)-4-((2-oxo-3-(pyridine-4-yl)-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)nicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(4-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(3-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; N-((1r,4r)-4-((3-(3-acetylphenyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-5-chloro-2-methylnicotinamide; N-((1r,4r)-4-((3-(4-acetylphenyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-5-chloro-2-methylnicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(4-(1-hydroxyethyl)phenyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(3-(hydroxymethyl)phenyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(4-(hydroxymethyl)phenyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(3-(hydroxymethyl)benzyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(4-(hydroxymethyl)benzyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-2-methyl-N -(( (1r,4r)-4-((2-oxo-3-phenethyl-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)nicotinamide; 5-Chloro-2-methyl-N -(( (1r,4r)-4-((2-oxo-3-(p- tolyl) -2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)nicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(4-methoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-2-methyl-N-((1r,4r)-4-((2-oxo-3-(4-(trifluoromethyl)phenyl)-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)nicotinamide; 5-Chloro-2-methyl-N-((1r,4r)-4-((2-oxo-3-(6-(trifluoromethyl)pyridine-3-yl)-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)nicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(6-methoxypyridine-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-2-methyl-N-((1r,4r)-4-((3-(6-methylpyridine-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)nicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(2,6-dimethylpyridine-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(2-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(6-(2,2-difluoroethoxy)pyridine-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 5-Chloro-N-((1r,4r)-4-((3-(6-ethoxypyridine-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)methyl)cyclohexyl)-2-methylnicotinamide; 2-Ethyl-N-((1r,4r)-4-((3-(4-methoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole