JP-2021534144-A5 -

Dates

Publication Date

20230526

Application Date

20190822

Description

The term "AGE antigen" refers to a substance that triggers an immune response in cells to AGE-modified proteins or peptides. This immune response to AGE-modified proteins or peptides does not involve the production of antibodies against proteins or peptides that are not AGE-modified. "Antibody that binds to AGE-modified proteins on cells,""Antibody that binds to AGE-modified cells,""Anti-AGEantibody," or "AGE antibody" preferably includes a constant region of the antibody and means an antibody, antibody fragment, or other protein or peptide that binds to an AGE-modified protein or AGE-modified peptide, which is a protein or peptide that is usually found to be bound to the surface of cells, preferably mammalian cells, more preferably human cells, cat cells, dog cells, horse cells, camelid cells (e.g., camel cells or alpaca cells), bovine cells, sheep cells, pig cells, or goat cells. "Antibody that binds to AGE-modified proteins on cells,""Antibody that binds to AGE-modified cells,""Anti-AGEantibody," or "AGE antibody" does not include an antibody or other protein that binds with the same specificity and selectivity to both AGE-modified proteins or peptides and the same proteins or peptides that are not AGE-modified (i.e., the presence of AGE modification does not increase binding). AGE-modified albumin is not an AGE-modified protein on a cell, because albumin is not a protein that is typically found bound to the surface of cells. "Antibodies that bind to AGE-modified proteins on cells,""antibodies that bind to AGE-modified cells,""anti-AGEantibodies," or "AGE antibodies" include only antibodies that result in the removal, destruction, or death of cells. This also includes antibodies conjugated to, for example, toxins, drugs, or other chemicals or particles. Preferably, the antibody is a monoclonal antibody, but polyclonal antibodies are also possible. The term "senescent cell lysant" refers to low-molecular-weight substances with a molecular weight of less than 900 daltons that destroy senescent cells. The term "senescent cell lysant" does not include antibodies, antibody conjugates, proteins, peptides, or biotherapies.