JP-2022507957-A5 -

Dates

Publication Date

20221205

Application Date

20191126

Description

Equal portionsThose skilled in the art will recognize, or can verify by conventional experimentation, numerous equivalents of the specific embodiments described herein. Such equivalents are intended to be included in the following claims.The present invention includes the following embodiments.<1>Compound of formula (I):[In the formula:X1and X2Each of these independently is H or (C1~C6) Alkyl or X1and X2These, together with the carbon atoms to which they are bonded, form (O);X3is, X1and X2Each independently of H or (C1~C6) Alkyl or X1and X2However, when they combine with the carbon atoms to which they are bonded to form = (O), they form -CH2- and X3is, X1and X2However, when they combine with the carbon atoms to which they are bonded to form = (O), they become -O-, -NH-, or -N(C1~C6) alkyl-;R1is, (C6~C10) A five-membered or six-membered heteroaryl compound containing aryl or one to three heteroatoms selected from N, O, and S, where the aryl and heteroaryl compounds are -OR10or -NR21R10It is replaced by and optionally one or more R11It has been replaced with;R2H, (C1~C6) alkyl, (C2~C6) Alkenil, (C1~C6) Haloalkyl, -NR12R13, (C3~C7) Carbocyclyl, (C3~C7) Cycloalkenyl, 5- to 7-membered heterocyclyl containing 1 to 3 heteroatoms selected from N, O, and S, (C6~C10) A 5-membered or 6-membered heteroaryl comprising an aryl or 1 to 3 heteroatoms selected from N, O, and S, wherein the alkyl is optionally one or more R18It is replaced with, and the carbocyclyl, (C3~C7) Cycloalkenyls, heterocyclyls, aryls, and heteroaryls may be optionally selected as one or more R19It has been replaced with;R3H, D, (C1~C6) alkyl, (C1~C6) Alkoxy, (C1~C6) Haloalkyl, (C1~C6) Haloalkoxy, or (C1~C6) is a hydroxyalkyl, where the alkyl is optionally one or more R14It has been replaced with;R4is H or (C1~C6) being alkyl; orR3and R4Together with the atoms to which they bond, they form a 5- to 7-membered heterocycline ring containing 1 to 3 heteroatoms selected from N, O, and S;R5and R7These are H, D, (C) respectively, independently.1~C6) alkyl, (C1~C6) Alkoxy, (C1~C6) Haloalkyl, (C1~C6) Haloalkoxy, or (C1~C6) is a hydroxyalkyl, where the above (C1~C6) The alkyl group is optionally substituted with one or more D;R6is, (C1~C6) alkyl, (C1~C6) Alkoxy, (C1~C6) Haloalkyl, (C1~C6) Haloalkoxy, or (C1~C6) is a hydroxyalkyl, where the alkyl is optionally (C1~C6) Alkoxy, (C1~C6) Haloalkoxy, -C(O)(C1~C6) alkyl, -C(O)OH, and -C(O)O(C1~C6) Each alkyl group is substituted with one or more substituents independently selected from the alkyl group;R8H, (C1~C6) alkyl, or (C1~C6) is a haloalkyl, where the alkyl is optionally (C3~C7) Carbocyclyl, 4- to 7-membered heterocyclyl containing 1 to 3 heteroatoms selected from N, O, and S, -NR16R17, and -C(O)NR16R17Each of them is substituted with one or more substituents independently selected;R9is halogen, (C1~C6) alkyl, (C1~C6) Alkoxy, (C1~C6) Haloalkyl, (C1~C6) are haloalkoxy, -OH, or CN;R10is, (C6~C10) A five-membered or six-membered heteroaryl compound containing aryl or one to three heteroatoms selected from N, O, and S, wherein the aryl and heteroaryl compounds optionally contain one or more R22It has been replaced with;Each R11Each instance is independently determined by halogen, (C1~C6) alkyl, (C1~C6) Alkoxy, (C1~C6) Haloalkyl, (C1~C6) are haloalkoxy, -OH, or CN;R12and R13Each of these independently is H or (C1~C6) is alkyl;Each R14Each occurrence is independently D, NR15R15', (C3~C7) Carbocyclyl, or a 3- to 7-membered heterocyclyl containing 1 to 3 heteroatoms selected from N, O, and S, wherein the carbocyclyl and heterocyclyl are optionally composed of halogens, (C1~C6) alkyl, (C1~C6) Alkoxy, (C1~C6) Haloalkyl, and (C1~C6) Each haloalkoxy is substituted with one or more substituents independently selected;R15and R15'Each of these independently is H or (C1~C6) is alkyl;R16and R17Each of these independently is H or (C1~C6) Alkyl orR16and R17Together with the nitrogen atom to which they are bonded, they form a 4- to 7-membered heterocycline ring that optionally includes one or two additional heteroatoms selected from N, O, and S;Each R18Each instance is independent, (C3~C7) Carbocyclyl, 5- to 7-membered heterocyclyl containing 1 to 3 heteroatoms selected from N, O, and S, (C6~C10) an aryl, or a 5-membered or 6-membered heteroaryl containing 1 to 3 heteroatoms selected from N, O, and S, wherein the carbocykrill, heterocyclyl, aryl, and heteroaryl are optionally one or more R20It has been replaced with;Each R19Each instance is independently determined by halogen, (C1~C6) alkyl, (C1~C6) Alkoxy, (C1~C6) Haloalkyl, (C1~C6) being a haloalkoxy, -OH, or CN; orTwo R's19When they are together and on adjacent atoms, (C6~C10) Forms a five-membered or six-membered heteroaryl ring containing aryl or one to three heteroatoms selected from N, O, and S, wherein the aryl and heteroaryl are optionally halogens, (C1~C6) alkyl, (C1~C6) Alkoxy, (C1~C6) Haloalkyl, (C1~C6) Substituted with one or more substituents independently selected f