JP-2022511515-A5 -

Dates

Publication Date

20221226

Application Date

20191219

Description

Please understand that both the above abstract and the following embodiments for carrying out the invention are illustrative and descriptive only, and do not limit the claimed invention.In embodiments of the present invention, for example, the following items are provided.(Item 1)Compounds having formula I:or a pharmaceutically acceptable salt or solvate thereof, wherein in the formula,X1and X2Each of them independently, N and CR2Selected from,R1and R2Each of these is independently selected from hydrogen, halo, cyano, optionally substituted alkyl, optionally substituted alkenyl, and optionally substituted alkynyl.R3However, it is a optionally substituted phenyl, optionally substituted pyridyl, optionally substituted pyrimidinyl, optionally substituted pyrazinyl, optionally substituted pyridadinyl, or optionally substituted pyrazolyl.X11and X12Each of these is independently selected from N and CH.R5'However, hydrogen was optionally substituted (C1-C6) alkyl, optionally substituted (C2-C6) Alkenyl, optionally replaced (C2-C6) Alkinyl, optionally replaced (C1-C6) Alkoxy, (C1-C6) Haloalkyl, (C1-C6) Haloalkoxy, (C1-C6) Hydroxyalkyl, cyano, halo, sulfonamide, -C(=O)R23, -C (=O) OR24, -NR32aR32b, -NR31aC(=O)R25,-NR31aC(=O)NR31aR31b, -C(=O)NR31aR31b, -S(O)2R27, -NR31aSO2R27, replaced by optional (C6-C14) Aryl, optionally replaced (C6-C14) Al-(C1-C2) alkyl, optionally substituted heteroaryl, optionally substituted heteroaryl-(C1-C2) alkyl, optionally substituted (C3-C8) Cycloalkyl, optionally substituted ((C3-C8)Cycloalkyl)-(C1-C2) alkyl, optionally substituted heterocyclo, optionally substituted heterocyclo-(C1-C2) alkyl, optionally substituted -O-(C6-C14) aryl, optionally substituted -O-(C6-C14) Al-(C1-C2) alkyl, optionally substituted -O-heteroaryl, optionally substituted -O-heteroaryl-(C1-C2) alkyl, optionally substituted -O-(C3-C8) Cycloalkyl, optionally substituted -O-((C3-C8)Cycloalkyl)-(C1-C2) alkyl, optionally substituted -O-heterocyclo, optionally substituted -O-heterocyclo-(C1-C2) Selected from alkyl groups,R5However, it was replaced by choice (C1-C6) alkyl, optionally substituted (C2-C6) Alkenyl, optionally replaced (C2-C6) Alkinyl, optionally replaced (C1-C6) Alkoxy, (C1-C6) Haloalkyl, (C1-C6) Haloalkoxy, (C1-C6) Hydroxyalkyl, cyano, halo, sulfonamide,-C(=O)R23, -C (=O) OR24, -NR32aR32b, -NR31aC(=O)R25, -NR31aC(=O)NR31aR31b, -C(=O)NR31aR31b, -S(O)2R27, -NR31aSO2R27, replaced by optional (C6-C14) Aryl, optionally replaced (C6-C14) Al-(C1-C2) alkyl, optionally substituted heteroaryl, optionally substituted heteroaryl-(C1-C2) alkyl, optionally substituted (C3-C8) Cycloalkyl, optionally substituted ((C3-C8)Cycloalkyl)-(C1-C2) alkyl, optionally substituted heterocyclo, optionally substituted heterocyclo-(C1-C2) alkyl, optionally substituted-O-(C6-C14) aryl, optionally substituted -O-(C6-C14) Al-(C1-C2) alkyl, optionally substituted -O-heteroaryl, optionally substituted -O-heteroaryl-(C1-C2) alkyl, optionally substituted -O-(C3-C8) Cycloalkyl, optionally substituted -O-((C3-C8)Cycloalkyl)-(C1-C2) alkyl, optionally substituted -O-heterocyclo, optionally substituted -O-heterocyclo-(C1-C2) Selected from alkyl groups, orR on neighboring atoms5one of the and R5'One of them is optionally substituted together with the atom to which they are bonded (C6-C14) Forms an aryl ring, or R on an adjacent atom5one of the and R5'One of them, together with the atom to which they are bonded, forms a heteroaryl ring that is optionally substituted, or R on an adjacent atom.5one of the and R5'One of them is optionally substituted together with the atom to which they are bonded (C3-C8) Forms a cycloalkyl ring or R on an adjacent atom5one of the and R5'One of these may, together with the atom to which they are bonded, form an optionally substituted heterocycloalkyl ring, or it may be R on an adjacent atom on the same atom to which they are bonded.5one of the and R5'One of them either forms an optionally substituted spirocycloalkyl ring together, or an R on an adjacent atom on the same atom to which they are bonded.5one of the and R5'One of them forms an optionally substituted spiroheterocycloalkyl ring,R6and R7Each of these is independently selected from hydrogen, halo, cyano, optionally substituted alkyl, optionally substituted alkenyl, and optionally substituted alkynyl.R23However, selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, amino, alkylamino, dialkylamino, cycloalkylamino, hydroxyalkyl, (amino)alkyl, (alkylamino)alkyl, (dialkylamino)alkyl, (cycloalkylamino)alkyl, (cycloalkyl)alkyl, aralkyl, (heterocyclo)alkyl, (heteroaryl)alkyl, (amino)(hydroxy)alkyl, (aralkylamino)alkyl, optionally substituted heterocyclo, optionally substituted heteroaryl, optionally substituted aryl, and optionally substituted cycloalkyl,R31aand R31bHowever, each is independently selected from the group consisting of hydrogen, optionally substituted alkyl, optional