JP-2022512378-A5 -

Dates

Publication Date

20221213

Application Date

20191206

Description

In other embodiments, the user-operated controller includes a scroll wheel mechanism operably associated with a rack and pinion rail assembly, wherein rotation of the wheel in a first direction results in a transition of at least one of the proximal and distal segments to an extended configuration, and rotation of the wheel in a second opposite direction results in a transition of at least one of the proximal and distal segments to a retracted configuration. The present invention provides, for example, the following: (Item 1) A device for treating the condition of a patient's nasal cavity, wherein the device is A multi-segment end effector for delivering energy to one or more target sites within the patient's nasal cavity. Equipped with, The multi-segment end effector is a device comprising a proximal segment separated from a distal segment. (Item 2) The proximal segment comprises a first set of flexible support elements arranged in a first configuration, and a first set of electrodes provided by the first set of support elements and configured to deliver energy to tissue at a first target site. The distal segment comprises a second set of flexible support elements arranged in a second configuration, and a second set of electrodes provided by the second set of support elements and configured to deliver energy to tissue at a second target site. The device described in item 1. (Item 3) The device according to item 2, wherein the proximal and distal segments are each convertible between a retracted configuration and an extended deployed configuration, such that when the first and second sets of the flexible support elements are in a deployed configuration, one or more of the individual first and second sets of electrodes are positioned at the first and second target sites. (Item 4) In the aforementioned expanded deployment configuration, the first set of support elements is A first pair of support columns, each having a loop shape and extending upward, A second pair of supports, each having a loop shape and extending downward, and A device as described in item 3, comprising the features described in item 3. (Item 5) The device according to item 3, wherein, in the extended deployment configuration, the second set of support elements comprises a second set of support columns, each of which has a loop shape extending outward and forming an open-end circumferential shape. (Item 6) The device according to item 3, wherein the first and second sets of the support elements comprise a deformable composite wire. (Item 7) The composite wire is the device according to item 6, comprising a shape memory material. (Item 8) The device according to item 1, wherein the first and second sets of electrodes are configured to deliver radio frequency (RF) energy to tissue at individual target sites within the nasal cavity, the individual target sites being associated with parasympathetic nerve supply. (Item 9) The device according to item 8, wherein the first and second sets of electrodes are configured to deliver RF energy at a level sufficient to therapeutically modulate the postganglionic parasympathetic nerves that distribute nerves to the nasal mucosa in the nerve innervation pathway within the patient's nasal cavity. (Item 10) The device according to item 9, wherein the condition is selected from the group consisting of allergic rhinitis, non-allergic rhinitis, chronic rhinitis, acute rhinitis, chronic sinusitis, acute sinusitis, chronic rhinosinusitis, acute rhinosinusitis, and drug-resistant rhinitis. (Item 11) A method for treating the condition of a patient's nasal cavity, wherein the method is The invention involves advancing a device comprising a multi-segment end effector for delivering energy to one or more target sites within the nasal cavity of the patient, wherein the multi-segment end effector comprises a proximal segment separated from a distal segment, The energy is delivered to the tissue at one or more target sites via the proximal and distal segments. Methods that include... (Item 12) The proximal segment comprises a first set of flexible support elements arranged in a first configuration, and a first set of electrodes provided by the first set of support elements and configured to deliver energy to tissue at a first target site. The distal segment comprises a second set of flexible support elements arranged in a second configuration, and a second set of electrodes provided by the second set of support elements and configured to deliver energy to tissue at a second target site. The method described in item 11. (Item 13) The method according to item 12, wherein the proximal and distal segments are each convertible between a retracted configuration and an extended deployed configuration, such that when the first and second sets of the flexible support elements are in a deployed configuration, one or more of the individual first and second sets of electrodes are positioned at the first and second target sites. (I