JP-2022514289-A5 -

Dates

Publication Date

20221209

Application Date

20191213

Description

The foregoing description of preferred embodiments is given merely as examples and is understood to be modifiable in various ways by those skilled in the art. Although various embodiments have been described above in some detail or in relation to one or more individual embodiments, those skilled in the art will be able to make numerous modifications to the disclosed embodiments without departing from the claims. The present invention includes the following embodiments. [Section 1] It is a system that electrically stimulates nerves, A first stimulator and a second stimulator, which electrically stimulate nerves and are spaced a first distance apart from each other, and a) Set the time interval as a function of the first distance and the propagation velocity of the nerve action potential. b) Inducing the electrical activity of nerves by activating the first stimulator for a first stimulation period, and c) After a time interval has elapsed following the end of the first period, the second stimulator is activated for the duration of the second stimulation period. Control device configured for A system that includes this. [Section 2] The system according to item 1, wherein the time interval includes a first period that is approximately equal to or greater than the quotient obtained by dividing the first distance by the propagation velocity of nerve action potentials. [Section 3] The system described in item 2, wherein the propagation velocity of nerve action potentials is approximately 0.5 mm/ms. [Section 4] The system according to any one of claims 1 to 3, wherein the first distance between the first stimulator and the second stimulator is approximately equal to or greater than 3 mm. [Section 5] The system described in item 3 or 4, wherein the first period is approximately equal to or longer than 6 ms. [Section 6] The system according to any one of claims 1 to 5, wherein the first distance between the first stimulator and the second stimulator is 5 mm or more. [Section 7] The system described in item 3 or 6, wherein the first period is approximately equal to or longer than 10 ms. [Section 8] The system according to any one of claims 1 to 7, wherein the first distance between the first stimulator and the second stimulator is approximately 6 mm. [Section 9] The system described in item 3 or 8, wherein the first period is approximately equal to or longer than 12 ms. [Section 10] The system according to any one of items 1 to 9, wherein the first distance is approximately 6.4 mm. [Section 11] The system described in item 3 or 10, wherein the first period is approximately equal to or longer than 12.8 ms. [Section 12] The system according to any one of claims 1 to 11, wherein the setting of the time interval is the sum of the first period and a buffer period that allows nerve recovery from stimulation. [Section 13] The system according to paragraph 12, wherein the buffer period is equal to or greater than the length of time required for the effect of the electroactivation induced in the nerve to fall below a predetermined threshold or disappear at the location of the second stimulator. [Section 14] A system as described in item 12 or 13, wherein the buffer period is 10 ms or longer. [Section 15] A system as described in any one of items 1 to 14, wherein the time interval is less than half the duration of the initial stimulation. [Section 16] The system according to any one of claims 1 to 15, wherein each of the first stimulator and the second stimulator includes one or more electrodes. [Section 17] The system according to any one of claims 1 to 16, further comprising attachment means for electrically coupling a first stimulator and a second stimulator to a nerve, wherein the attachment means defines an opening having an inner diameter for receiving a nerve. [Section 18] The system described in item 17, having an inner diameter approximately equal to or greater than 5 mm. [Section 19] The system described in item 17 or 18, wherein the inner diameter is approximately equal to or less than 13 mm. [Section 20] A system as described in any one of items 17 to 19, having an inner diameter of approximately 7.5 mm. [Section 21] A system as described in any one of items 1 to 20, wherein the system is implanted in a nerve. [Section 22] A system, as described in any one of items 1 through 21, in which the system surrounds a nerve. [Section 23] The system described in paragraph 21 or 22, wherein the nerves are autonomic nerves. [Section 24] A system described in any one of items 21 to 23, wherein the nerve is the splenic nerve. [Section 25] The system described in paragraph 21 or 22, wherein the nerves are unmyelinated. [Section 26] The control device further, The system according to any one of claims 1 to 25, configured to perform step b) after a time interval has elapsed following the end of the second stimulation period. [Section 27] The control device further, The system according to item 25, configured to alternately stimula