JP-2022515369-A5 -

Dates

Publication Date

20221223

Application Date

20191217

Description

Other EmbodimentsThis disclosure merely provides representative embodiments of the disclosure. Those skilled in the art will readily understand that various changes, modifications, and variations can be made within this disclosure and its claims without departing from the essence and scope of the disclosure as defined in the following claims.The present invention provides, for example, the following items:(Item 1)Equation (I):A compound of, a pharmaceutically acceptable salt thereof, any solvate of any of the foregoing, and at least one substance selected from any deuterated derivative of any of the foregoing, wherein in the formula,(i) Each R1Independently,halogen group,Hydroxy,Thiol,amino,Cyano,-OC(OC)C1~C6Linear, branched, and cyclic alkyl groups,-C(O)OC1~C6Linear, branched, and cyclic alkyl groups,- NHC(O)C1~C6Linear, branched, and cyclic alkyl groups,- C(O)NHC1~C6Linear, branched, and cyclic alkyl groups,-NHC(O)aryl group,-C(O)NHaryl group,-NHC(O) heteroaryl group,-C(O)NH heteroaryl group,- NHS (O)2C1~C6Linear, branched, and cyclic alkyl groups,-S(O)2NHC1~C6Linear, branched, and cyclic alkyl groups,- NHS (O)2Aryl group,-S(O)2NHaryl group,- NHS (O)2heteroaryl group,-S(O)2NH heteroaryl group,-NHC(O)NHC1~C6Linear, branched, and cyclic alkyl groups,-NHC(O)NHaryl group,-NHC(O)NH heteroaryl group,C1~C6Linear, branched, and cyclic alkyl groups,C2~C6Linear, branched, and cyclic alkenyl groups,C1~C6Linear, branched, and cyclic hydroxyalkyl groups,C1~C6Linear, branched, and cyclic alkoxy groups,C1~C6Linear, branched, and cyclic thioalkyl groups,C1~C6Linear, branched, and cyclic haloalkyl groups,C1~C6Linear, branched, and cyclic haloaminoalkyl groups,C1~C6Linear, branched, and cyclic halothioalkyl groups,C1~C6Linear, branched, and cyclic haloalkoxy groups,benzyloxy, benzylamino, or benzylthio group,3-6 member heterocycloalkenyl group,3- to 6-membered heterocycloalkyl groups, andSelected from 5- and 6-membered heteroaryl groups, orTwo R's1The group, along with the carbon atoms to which they are bonded, is C4~C8Forming a cycloalkyl group, an aryl group, or a heteroaryl group,(ii) Each R2Independently,halogen group,Hydroxy,Thiol,amino,Cyano,- NHC(O)C1~C6Linear, branched, and cyclic alkyl groups,- C(O)NHC1~C6Linear, branched, and cyclic alkyl groups,-NHC(O)aryl group,-C(O)NHaryl group,-NHC(O) heteroaryl group,-C(O)NH heteroaryl group,- NHS (O)2C1~C6Linear, branched, and cyclic alkyl groups,-S(O)2NHC1~C6Linear, branched, and cyclic alkyl groups,- NHS (O)2Aryl group,-S(O)2NHaryl group,- NHS (O)2heteroaryl group,-S(O)2NH heteroaryl group,-NHC(O)NHC1~C4Linear, branched, and cyclic alkyl groups,-NHC(O)NHaryl group,-NHC(O)NH heteroaryl group,C1~C4Linear, branched, and cyclic alkyl groups,C2~C4Linear, branched, and cyclic alkenyl groups,C1~C4Linear, branched, and cyclic hydroxyalkyl groups,C1~C4Linear, branched, and cyclic alkoxy groups,C1~C4Linear, branched, and cyclic thioalkyl groups,C1~C4Linear, branched, and cyclic haloalkyl groups,C1~C4Linear, branched, and cyclic haloaminoalkyl groups,C1~C4Linear, branched, and cyclic halothioalkyl groups, andC1~C4Selected from linear, branched, and cyclic haloalkoxy groups,(iii)m is selected from 0, 1, 2, 3, and 4,(iv)n is selected from 0, 1, 2, 3, 4, and 5.(v) Y is a divalent C1~C8Linear and branched cyclic alkyl groups, divalent carbon1~C8Linear and branched alkoxy groups, divalent carbon1~C8Linear and branched aminoalkyl groups, and divalent C1~C8Linear and branched thioalkyl groups,C1~C6alkyl group,Aryl group,heteroaryl group,halogen group,Hydroxy, andSelected from the divalent alkyl group, the divalent alkoxy group, the divalent aminoalkyl group, and the divalent thioalkyl group, which are optionally substituted with at least one group selected from amino,(vi)R3and R4Each of them is independent,hydrogen,Hydroxy,Thiol,amino,halogen group,C1~C6Linear, branched, and cyclic hydroxyalkyl groups,C1~C6Linear, branched, and cyclic alkoxy groups,C1~C6Linear, branched, and cyclic thioalkyl groups,C1~C6Linear, branched, and cyclic haloalkyl groups,C1~C6Linear, branched, and cyclic haloaminoalkyl groups,C1~C6Linear, branched, and cyclic halothioalkyl groups,C1~C6Selected from linear, branched, and cyclic haloalkoxy groups, orR3and R4Along with the carbon atoms to which they are bonded, C3~C6Forming a cycloalkyl group or carbonyl group,(vii)R5and R6Each of them is independent,hydrogen,Thiol,amino,halogen group,Hydroxy,C1~C6Linear, branched, and cyclic hydroxyalkyl groups,C1~C6Linear, branched, and cyclic alkoxy groups,C1~C6Linear, branched, and cyclic thioalkyl groups,C1~C6Linear, branched, and cyclic haloalkyl groups,C1~C6Linear, branched, and cyclic haloaminoalkyl groups,C1~C6Linear, branched, and cyclic halothioalkyl groups,C1~C6Linear, branched, and cyclic haloalkoxy groups,-OC(OC)C1~C6Linear, branched, and cyclic alkyl groups,-C(O)OC1~C6Linear, branched, and cyclic alkyl groups,- NHC(O)C1~C6Linear, branched, and cyclic alkyl groups,- C(O)NHC1~C6Linear, branched, and cyclic alkyl groups