JP-2022527213-A5 -

Dates

Publication Date

20230517

Application Date

20200409

Description

In certain embodiments, this disclosure relates to formula (I) The present invention provides a process for preparing a compound of formula (XXII) or a pharmaceutically acceptable salt thereof, the process comprising reacting a compound of formula (XXIII) with a compound of formula (VIII) to produce a compound of formula (XXIII): During the ceremony, L3 is a leaving group ( R 5 is a 2-fluorobenzyl or oxygen protecting group. In a particular preferred embodiment, R 5 is 2-fluorobenzyl. In a particular preferred embodiment, R 6 is a resonance-receiving nitrogen protecting group such as tert-butyloxycarbonyl ( Boc ); 9-fluorenylmethyloxycarbonyl (Fmoc); acetyl (Ac); benzoyl (Bz); carbamate; tosyl (Ts); sulfonamides selected from Nosyl and Nps, and a nitrogen protecting group selected from trifluoroacetyl. In a particular preferred embodiment, R 6 is tert-butyloxycarbonyl (Boc). In a particular embodiment, R 8 is a C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, most preferably methyl. In a particular embodiment, the process is for preparing a compound of formula (XXIII). The terms "amine" and "amino" are recognized in the art and refer to both unsubstituted and substituted amines, and their salts, for example, part of which is It can be expressed as, In the formula, R9 , R10 , and R10 ' each independently represent a hydrogen atom or a hydrocarbyl group, or R9 and R10 , together with the N atom to which they are bonded, complete a heterocycle having 4 to 8 atoms in its cyclic structure . The term "carbamate" is recognized in the relevant technical field, and is based on This refers to the fact that, in the formula, R9 and R10 independently represent hydrogen or a hydrocarbyl group.