JP-2022531388-A5 -

Dates

Publication Date

20230511

Application Date

20200501

Description

Those skilled in the art will be able to recognize or confirm many equivalents to the specific embodiments described herein by means of ordinary experimentation. The scope of the embodiments described herein is not intended to be limited to embodiments for carrying out the invention described above, but rather as described in the appended claims. Those skilled in the art will understand that various changes and modifications to this description can be made without departing from the spirit or scope of the invention, as defined in the following claims.The present invention provides, for example, the following items:(Item 1)Compound of formula I:or a pharmaceutically acceptable salt thereof, in the formula,X, Y, Z, Y', and Z' are independently selected from CH and N, respectively, and the hydrogen of CH is R5CH is a combination of X, Y, Z, Y', and Z', and can be substituted with at least three selected from X, Y, Z, Y', and Z'.R1However, C1-6Alkyl, C3-10Selected from the group consisting of cycloalkyl, 3-10 membered heterocyclyl, 3-10 membered heteroaryl, and phenyl, C1-6Alkyl, C3-10Cycloalkyl, 3-10 membered heterocyclyl, 3-10 membered heteroaryl, or phenyl is a halogen, C(O)N(R)9)2, N(R9)2, C3-7Cycloalkyl, phenyl, 3-10 member heteroaryl, and C1-6They are optionally substituted with one or more substituents independently selected from the group consisting of alkoxys,R12However, C1-6Alkyl, C3-10Selected from the group consisting of cycloalkyl, 3-10 membered heterocyclyl, 3-10 membered heteroaryl, and phenyl, the C1-6Alkyl, C3-10Cycloalkyl, 3-10 membered heterocyclyl, 3-10 membered heteroaryl, or phenyl is a halogen, -OH, -CN, C1-6Alkyl, C1-6Haloalkyl and C1-6They are optionally substituted with one or more substituents independently selected from the group consisting of alkoxys, orTwo R on adjacent carbons12However, R12Together with the two carbon atoms to which it is bonded, it can form a carbocyclic ring.x is 0, 1, or 2,R2However, hydrogen or C1-4It is alkyl,R3However, hydrogen, C1-6Alkyl, C3-10Selected from the group consisting of cycloalkyl, 3-10 membered heterocyclyl, 3-10 membered heteroaryl, and phenyl, R4However, C1-6Selected from alkyl and hydrogen, or R3and R4However, R3and R4Together with the carbon bonded to C3-7It may form a cycloalkylene or a 3- to 7-membered heterocyclene, and the C1-6Alkyl, C3-10Cycloalkyl, 3-10 membered heterocyclyl, 3-10 membered heteroaryl, phenyl, C3-7Cycloalkylene or 3- to 7-membered heterocyclene, one or more R7It can be optionally substituted,Each R5However, halogen, C1-6Alkyl, C1-6Haloalkyl, C1-6Alkylene-N(R)9)2, C1-6Alkylene-OC3-10Cycloalkyl, C1-6Alkoxy, C optionally substituted with one or more halogens3-10Cycloalkyl-substituted C1-6Alkoxy, C1-6Haloalkoxy, one or more halogens or C1-63-10 member heterocyclyls, 3-10 member heteroaryls, C, which are optionally substituted with alkoxys.1-6Alkylene-OH, C1-6Alkylene-C1-6Alkoxy, OH, N(R)9)2, -C(O)OR8, C(O)N(R9)2, C1-6Alkylene-CN,-CN,-S(O)2-C1-6Alkyl, C1-6Alkylene-S(O)2-C1-6Alkyl, -S(O)2-N(R)9)2, -OC(OC)C1-6Alkyl, one or more halogens or C1-6-O-C molecules optionally substituted with alkyl groups3-10Cycloalkyls, as well as halogens, C1-6Alkyl and C1-6C is optionally substituted with one or more substituents selected from alkoxys.3-10Independently selected from the group consisting of cycloalkyls,n is selected from the group consisting of 0, 1, 2, and 3.R7However, phenyl, C1-6Alkoxy, -OH, -N(R)9)2, -NR9-SO2-C1-6Alkyl, -O-(C1-6Alkylene)-phenyl, C3-10Cycloalkyl, -C(O)OR8, -C(O)N(R9)2, -NR10C(O)-R11, -CN, -S(O)2-C1-6Alkyl, -S(O)2-N(R)9)2Each of the following is independently selected from the group consisting of 3- to 10-membered heterocyclyls and 3- to 10-membered heteroaryls: phenyl, C3-10Cycloalkyl, 3-10 membered heterocyclyl, or 3-10 membered heteroaryl is C1-6Alkyl, halogen, -OH, C1-6Alkoxy, and -N(R9)2They are optionally substituted with one or more substituents independently selected from the group consisting of,R8However, hydrogen or C1-6It is alkyl,Each R9However, hydrogen, C1-6Alkyl and -(C1-6Independently selected from the group consisting of alkylene)-OH, or two R9However, the two R's mentioned above9Together with the nitrogen atom bonded thereto, it can form a heterocycle which is optionally substituted with one or more substituents independently selected from halogens and -OH groups.Each R10However, independently, hydrogen or C1-6It is alkyl,R11However, C1-6Alkyl, C1-6Alkoxy, and -O-(C1-6Selected from the group consisting of alkylene-phenyl,R3and R4However, if both are hydrogen, then at least one selected from X, Y, Z, Y', and Z' is N, and the compound of formula I or a pharmaceutically acceptable salt thereof,A pharmaceutical composition comprising a pharmaceutically acceptable excipient.(Item 2)The pharmaceutical composition described in item 1, wherein one of X, Y, Z, Y', and Z' is N, and the other four are CH.(Item 3)The aforementioned compound is the compound of formula I-a:or a pharmaceutically acceptable sal