JP-2022531457-A5 -

Dates

Publication Date

20230512

Application Date

20200507

Description

In some embodiments, a first blood pump communicates with a first controller, and a second blood pump communicates with a second controller. For example, the first and second controllers are Automated Impella Controllers® (AICs). In one embodiment, the first and second controllers communicate to determine the pressure difference between the measured arterial pressure and the measured renal venous pressure. [Invention 1001] A method for regulating renal function in a patient, The first stage involves inserting the blood pump into the patient's heart; A step of operating the first blood pump to increase the aortic pressure; The step of inserting the second blood pump into the inferior vena cava of the patient; and The step of operating the second blood pump and the first blood pump. Includes, A method for operating the first and second blood pumps to achieve a target pressure drop at a location within the patient's renal vein or inferior vena cava. [Invention 1002] The method of the present invention 1001, wherein the step of operating the second blood pump includes pumping the second blood pump while the first blood pump is pumping blood. [Invention 1003] The method of the present invention 1002, wherein the step of activating the first blood pump is to maintain or increase arterial pressure in the renal artery. [Invention 1004] The method of the present invention 1003, wherein the step of activating a second blood pump maintains or reduces renal venous pressure. [Invention 1005] The method of the present invention 1004, comprising the steps of activating a first blood pump to increase arterial pressure and activating a second blood pump to decrease renal venous pressure. [Invention 1006] The method of the present invention 1002, wherein the aforementioned location is a vascular junction where the patient's renal vein and inferior vena cava connect. [Invention 1007] The method of the present invention 1002, wherein the target pressure drop increases blood flow through the kidneys and increases renal output. [Invention 1008] The method of the present invention 1007, wherein the target pressure drop is approximately 4 mmHg to approximately 8 mmHg. [Invention 1009] The method of the present invention 1007, wherein the target pressure drop is approximately 5 mmHg to approximately 7 mmHg. [Invention 1010] The method of the present invention 1002, wherein the target pressure drop corresponds to a blood pressure drop across the kidney. [Invention 1011] The method of the present invention 1002, wherein the combined operation of a first and second blood pumps delivers humoral factors to the patient's renal receptors to stimulate increased urine output from the kidneys. [Invention 1012] The first blood pump, Pump motor and; The pump housing located distal to the pump motor and surrounding the rotor; A cannula extending distally to the pump housing; A non-traumatic extension extending distally from the cannula and A method of the present invention 1001 comprising the above. [Invention 1013] The second blood pump, Pump motor and; The pump housing located distal to the pump motor and surrounding the rotor; A cannula extending distally to the pump housing and A method of the present invention 1001 comprising the above. [Invention 1014] The method of the present invention 1012, wherein the second blood pump further comprises a non-traumatic extension extending distally from the cannula. [Invention 1015] The method of the present invention 1012, wherein the second pump is positioned inside the inferior vena cava such that the distal tip of the non-traumatic extension extends to a position adjacent to the outlet of the renal vein. [Invention 1016] The method according to the present invention 1001, wherein the first blood pump is inserted into the patient's ventricle. [Invention 1017] A method according to the present invention 1001, wherein regulation of renal function occurs during or after surgery. [Invention 1018] A first mechanical circulatory support device configured to reduce the load on the ventricle, atrium, or atrium and ventricle, or both atrium and both ventricle; A second mechanical circulatory support device, configured to be positioned within a vein and to be operated by pumping blood within the vein; A controller configured to operate both the first and second mechanical circulation support devices It is equipped with, The first and second mechanical circulatory support devices are configured to achieve a target pressure drop in the renal vein when operated simultaneously. A system to improve kidney function. [Invention 1019] The controller Receiving arterial pressure from the first mechanical circulatory support device and venous pressure from the second mechanical circulatory support device; Determining that the pressure drop in the renal vein is below the target pressure drop in the said renal vein; and To achieve the target pressure drop in the renal vein, the operation of at least one of the first mecha