JP-2022531899-A5 -

Dates

Publication Date

20230516

Application Date

20200506

Description

While the above text is described in some detail with figures and examples for clarity and understanding, it will be understood by those skilled in the art that numerous and varied modifications can be made without departing from the spirit of this disclosure. Therefore, it should be clearly understood that the forms disclosed herein are merely illustrative and not intended to limit the scope of this disclosure, but rather encompass all modifications and alternatives that are in line with the true scope and spirit of the invention. Another aspect of the present invention may be as follows: [1] A compound selected from formulas (I), (II), and (III), or a pharmaceutically acceptable salt of any of the above, [Chemical formula 1]During the ceremony, Rings A1A , A1B , and A1C are independent of each other. [Chemical 2] Selected from the group consisting of, Rings A 2A , A 2B , and A 2C are independent of each other. [Chemical 3] Selected from the group consisting of, B1A is an optionally substituted [5,6] bicyclic heteroaryl or optionally substituted [5,6] bicyclic heterocyclyl, and B1A is bonded to the 1' position of ring A1A . B2A is an optionally substituted [5,6] bicyclic heteroaryl or optionally substituted [5,6] bicyclic heterocyclyl, and B2A is bonded to the 1' position of ring A2A . B1B is an optionally substituted [5,6] bicyclic heteroaryl or optionally substituted [5,6] bicyclic heterocyclyl, and B1B is bonded to the 1' position of ring A1B . B 2B is an optionally substituted [5,6] bicyclic heteroaryl or optionally substituted [5,6] bicyclic heterocyclyl, and B 2B is bonded to the 1' position of ring A 2B . B1C is an optionally substituted [5,6] bicyclic heteroaryl or optionally substituted [5,6] bicyclic heterocyclyl, and B1C is bonded to the 1' position of ring A1C . B 2C is an optionally substituted [5,6] bicyclic heteroaryl or optionally substituted [5,6] bicyclic heterocyclyl, and B 2C is bonded to the 1' position of ring A 2C . X1A , X3A , X1B , X3B , X1C, and X3C independently contain OH, O- , SH, S-, O (unsubstituted C1-4 alkyl ), S (unsubstituted C1-4 alkyl ), O-CH2 - O-C(=O)-(unsubstituted C1-4 alkyl ), S-CH2 - O -C(=O)-(unsubstituted C1-4 alkyl), O-CH2 - O-C(=O)-O-(unsubstituted C1-4 alkyl ), S-CH2 - O-C(=O)-O-(unsubstituted C1-4 alkyl ) , [C4] And, X2A , X4A , X2B , X4B , X2C , and X4C are independently O or S. R 1A is hydrogen or a halogen, and R 1A is bonded to the 2' position of ring A 1A . R 2A contains hydrogen, halogens, hydroxyl, unsubstituted C1-4 alkoxy and [C5] Selected from the group consisting of, R 2A is bonded to the 2' position of ring A 1A , and R 2A is [Case 6] In this case, * indicates the bond point to the 4' position of ring A 1A , R 3A is hydrogen or a halogen, and R 3A is bonded to the 3' position of ring A 2A . R 4A is selected from the group consisting of hydrogen, halogen, hydroxyl, and unsubstituted C1-4 alkoxy , and R 4A is bonded to the 3' position of ring A 2A . R 5A is hydrogen, and R 5A is bonded to the 4' position of ring A 2A , or R4A and R5A together​ [C7] It forms, and each * indicates a bond point to ring A 2A , R 1B is hydrogen or a halogen, and R 1B is bonded to the 3' position of ring A 1B . R 2B is selected from the group consisting of hydrogen, halogen, hydroxyl, and unsubstituted C 1-4 alkoxy, and R 2B is bonded to the 3' position of ring A 1B . R 3B is hydrogen or a halogen, and R 3B is bonded to the 3' position of ring A 2B . R 4B is selected from the group consisting of hydrogen, halogen, hydroxyl, and unsubstituted C1-4 alkoxy , and R 4B is bonded to the 3' position of ring A 2B . R 5B is hydrogen, and R 5B is bonded to the 4' position of ring A 1B . R 6B is hydrogen, and R 6B is bonded to the 4' position of ring A 1B , or R2B and R5B together​ [Chem.8] It forms, and each * indicates a bonding point to ring A 1B , R4B and R6B together​ [Chem.9] It forms, and each * indicates a bonding point to ring A 2B , R 1C is hydrogen or a halogen, and R 1C is bonded to the 2' position of ring A 1C . R 2C is hydrogen, halogen, hydroxyl, unsubstituted C1-4 alkoxy and [Chemical formula 10] Selected from the group consisting of, R 2C is bonded to the 2' position of ring A 1C , and R 2C is [Chemical formula 11] In this case, * indicates the bond point to the 4' position of ring A 1C , R 3C is hydrogen or a halogen, and R 3C is bonded to the 2' position of ring A 2C . R 4C is hydrogen, halogen, hydroxyl, unsubstituted C1-4 alkoxy and [Chemical formula 12] Selected from the group consisting of, R 4C is bonded to the 2' position of ring A 2C , and R 4C is [Chem.13] In this case, * indicates the bond point to the 4' position of ring A 2C , However, if the compound has the structure of formula (I) and ring A 1A is [Chem.14] And ring A 2A is [Chem.15] If B1A is adenine or guanine and B2A is adenine or guanine, then at least one of X1A and X3A is SH or S-, or at least one of X2A and X4A is S. However, if the compound has the structure of formula (I) and ring A 1A is [