JP-2022532340-A5 -

Dates

Publication Date

20230515

Application Date

20200514

Description

Other EmbodimentsThis disclosure provides merely exemplary embodiments of the invention. Those skilled in the art will readily recognize from this disclosure, the accompanying drawings, and the claims that various changes, modifications, and variations can be made without departing from the spirit and scope of the invention as defined in the following claims.The present invention provides, for example, the following items:(Item 1)Compound of formula (I),The tautomer, any of the pharmaceutically acceptable salts described above, and/or any of the deuterated derivatives described above,During the ceremony,(i) R0However, the following options are selected:(a) C1~C8Linear, branched, and cyclic alkyl groups, wherein the alkyl group has 1 to 4 RAC is arbitrarily replaced by1~C8Linear, branched, and cyclic alkyl groups, as(b) 1 to 4 RAA 5- to 14-membered aromatic ring that is arbitrarily substituted with,Each RAHowever, independently, halogens, cyano, hydroxy, thiol, sulfonic acid, sulfonamide, sulfinamide, amino, amide, carboxylic acid, 5-10 membered aromatic rings, and C1~C6Selected from linear, branched, and cyclic groups,RAThe amide nitrogen atom in the amide is optionally substituted with a heterocyclyl group which is optionally further substituted with an oxo group.Said C1~C6The linear, branched, and cyclic groups are selected from alkyl, alkoxy, thioalkyl, alkylsulfoxide, alkylsulfonyl, alkylsulfonamide, alkylsulfinamide, aminoalkyl, and alkylamide.The aforementioned 5-10 member aromatic ring and C1~C6Linear, branched, and cyclic groups, halogens, C1~C6Linear, branched, and cyclic groups, as well as methoxy groups, can be optionally substituted with 1 to 4 substituents.RAThe base is R2Base RBA 5-14 member aromatic ring, which can be arbitrarily bonded to the base,(ii) R1However, the following options are selected:(a) Hydrogen,(b) C1~C8Linear, branched, and cyclic alkyl groups, wherein the alkyl group ishalogen,Cyano,Cyanoalkyl,Hydroxy,Alkyl sulfonyl, andC1~C6The C is optionally substituted with 1 to 4 substituents independently selected from linear, branched, and cyclic groups.1~C6Linear, branched, and cyclic groups are independently selected from alkyl groups and alkyl groups, and the C1~C6Linear, branched, and cyclic groups,halogen,Hydroxy, andC1~C6C is optionally substituted with 1 to 4 substituents independently selected from linear, branched, and cyclic alkoxy groups.1~C8Linear, branched, and cyclic alkyl groups,(c)halogen,Cyano,Cyanoalkyl,sulfone,Sulfonamide,Hydroxy, andC optionally substituted with 1 to 4 halogen or alkoxy groups1~C6C is optionally substituted with 1 to 4 substituents independently selected from linear, branched, and cyclic alkyl groups.1~C8Linear, branched, and cyclic alkoxy or cyclic thioalkyl groups,(d) C1~C6C optionally substituted with linear or branched alkyl groups1~C6Linear, branched, and cyclic alkylsulfonyl groups,(e)C1~C6An aminosulfonyl group optionally substituted with one or two substituents independently selected from linear, branched, and cyclic alkyl groups,(f) C1~C6Linear, branched, and cyclic alkylsulfonylamino groups, as(g)C1~C6A phosphine oxide group optionally substituted with one or two substituents independently selected from linear, branched, and cyclic alkyl groups,(h) C1~C6Linear, branched, and cyclic trialkylsilyl groups,(i) C1~C6alkylamide,(iii) R2However, 5-membered and 6-membered heterogeneities (oxo and/or C)1~C6Selected from a 5-6 membered aromatic ring containing 0-4 heteroatoms selected from O, N, and S (optionally substituted with linear and branched alkyl groups), wherein the 5-membered aromatic ring contains 1-4 RBThe group is optionally substituted, and the six-membered aromatic ring has 1 to 5 RBThe base is arbitrarily substituted, and the RBThe base, independently,It is an amide, C1~C6Linear, branched, and cyclic alkyl groups (optionally substituted with heteroaryls), 4- to 6-membered heterocyclines (oxo, C)1~C6The amide nitrogen atom is optionally substituted with one to three groups selected from linear, branched, and cyclic alkyl groups, hydroxyalkyl groups, amides, alkylsulfonyl groups, and acetamides, or the amide nitrogen atom is a 3-8 membered heterocyclyl ring (alkylsulfonyl or C1~C6Amides that form part of a linear, branched, or optionally substituted cyclic alkyl groupImidazoridine-2,4-Zeon,Heterocyclyls, which are oxo, acyl, and C1~C6Heterocyclines, which are linear, branched, and cyclic alkyl groups, optionally substituted with one or more groups independently selected from 1 to 3 groups independently selected from oxo, hydroxy, and acyl groups.C1~C6Phosphorous acid optionally esterified with a linear, branched, or cyclic alkyl group,Ji (C1~C6) Alkylphosphine oxide,C1~C6(C) optionally esterified with a linear, branched, or cyclic alkyl group.1~C6) Alkylphosphinic acid,halogen,Cyano,Hydroxy,Uronic acid or C1~C6Carboxylic acids optionally esterified with linear, branched, or cyclic alkyl groups,Oxo,Dihydroxylboryl,Five- and six-membe