JP-2022532706-A5 -

Dates

Publication Date

20230512

Application Date

20200507

Description

As will be understood by those skilled in the art, for all purposes, and especially in providing written explanations, all scopes disclosed herein also encompass all possible sub-scopes and combinations of their sub-scopes. Any enumerated scope can be readily recognized as sufficiently explainable and enable the decomposition of the same scope into at least equal halves, thirds, quarters, fifths, tenths, etc. As a non-limiting example, each scope considered herein can readily be decomposed into lower third, middle third, upper third, etc. Also, as will be understood by those skilled in the art, all language such as “maximum,” “at least,” “greater than,” “less than,” etc., includes the enumerated numbers and refers to scopes that can be decomposed into sub-scopes as later considered above. Finally, as will be understood by those skilled in the art, a scope includes each individual member. The present invention encompasses the following embodiments. (Embodiment 1) Compound of formula I', (I')TL-L a -CE-HD or its stereoisomer or tautomer, or a pharmaceutically acceptable salt, prodrug, amide, or ester thereof, wherein in the formula, i) TL is a part of formula IIa, IIb, IIIa, IIIb, IIIc, or IIId, During the ceremony, Q 1 Q 2 Q 3 Q 4 Q 5 Q 6 , and Q 8 Each of them independently contains nitrogen or -CR b - and each R b These are independently hydrogen, halogen, or lower alkyl, R 1 This is hydrogen, optionally substituted alkyl, optionally substituted non-aromatic carbocyclic group, optionally substituted aryl group, optionally substituted heterocycloalkyl group, optionally substituted heteroaryl group, optionally substituted (carbocyclic)alkyl group, optionally substituted aralkyl group, optionally substituted (heterocycloalkyl)alkyl group, optionally substituted (heteroaryl)alkyl group, optionally substituted amino group, optionally substituted C-carboxyl group or O-carboxyl group, -CN, optionally substituted carbamoyl group, or optionally substituted carbamoylalkyl group, wherein the nitrogen of the carbamoyl group or carbamoylalkyl group is optionally a heteroatom in the ring structure. R 2 is hydrogen, halogen, optionally substituted alkyl, optionally substituted cycloalkyl, or -CN, R 3 is hydrogen or a lower alkyl group, R 4 This is an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted non-aromatic carbocyclic group, an optionally substituted aryl group, an optionally substituted heterocyclic group, an optionally substituted heteroaryl group, an optionally substituted (carbocyclic) alkyl group, an optionally substituted aralkyl group, an optionally substituted (heterocycloalkyl) alkyl group, an optionally substituted (heteroaryl) alkyl group, an optionally substituted amino group, an optionally substituted sulfamoyl group, an optionally substituted carbamoyl group, or an optionally substituted carbamoylalkyl group, wherein the nitrogen of the carbamoyl group or carbamoylalkyl group is optionally a heteroatom in the ring structure. R 5 is hydroxy, NH 2 , alkylamino, alkanoylamino, or alkylsulfonylamino, Alternatively, R 4 and R 5 However, together with the carbon atoms to which they are bonded, they form a five-membered or six-membered optionally substituted non-aromatic carbocyclic group, an optionally substituted aryl group, an optionally substituted heterocyclic group, or an optionally substituted heteroaryl group. Alternatively, R 4 and R 5 However, together with the carbon atoms to which they bond, they form a spirocyclic ring or a spiroheterocyclic ring with 7 to 11 members, which can be optionally substituted. Alk is an alkyl group that is substituted with hydrogen or optionally substituted.