JP-2022533069-A5 -

Dates

Publication Date

20230516

Application Date

20200508

Description

In some aspects of the various aspects described herein, the compound represented by formula (I) is a compound represented by formula (XVI): Represented by formula (XVI), where R 19 is a haloalkyl; R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , R 11 , R 12 , R 15 , R 16 , R 17 , n, and m are as defined for formula (I). In some exemplary compounds represented by formula (XVI), m is 1 or 2; n is 1 or 2; R 1 , R 2 , R 4 , R 6 , R 11 , R 15 , and R 16 are H; R 3 and R 7 are OH; R 12 is H or -OH; R 17 is methyl; and R 19 is a haloalkyl, for example, -CH₂F . In some other exemplary compounds represented by formula (XVI), m is 1 or 2; n is 1 or 2; R1 , R2 , R4 , R6 , R11 , R15, and R16 are H; R3 is -OSO3- ; R7 is OH; R12 is H or -OH ; R17 is methyl; and R19 is a haloalkyl, for example, -CH2F . In some aspects of the various aspects described herein, the compound represented by formula (I) is a compound represented by formula (XVII): Represented by formula (XVII), where R 19 is a haloalkyl; R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , R 11 , R 12 , R 15 , R 16 , R 17 , n and m are as defined for formula (I). In some exemplary compounds represented by formula (XVII), m is 1 or 2; n is 1 or 2; R 1 , R 2 , R 4 , R 6 , R 11 , R 15 , R 16 are H; R 3 and R 7 are OH; R 12 is H or OH; R 17 is methyl; and R 19 is a haloalkyl. In some other exemplary compounds represented by formula (XVII), m is 1 or 2; n is 1 or 2; R1 , R2 , R4 , R6 , R11 , R15 , and R16 are H; R3 is -OSO3- ; R7 is OH; R12 is H or -OH ; R17 is methyl; and R19 is a haloalkyl, for example, -CH2F . In some aspects of the various aspects described herein, the compound represented by formula (I) is a compound represented by formula (XVIII): Represented by , where R 19 is a haloalkyl; R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , R 11 , R 12 , R 15 , R 16 , R 17 , n and m are as defined for formula (I). In some exemplary compounds represented by formula (XVIII), m is 1 or 2; n is 1 or 2; R 1 , R 2 , R 4 , R 6 , R 11 , R 15 , R 16 are H; R 3 and R 7 are OH; R 12 is H or OH; R 17 is methyl; and R 19 is a haloalkyl, for example, -CH₂F . In some other exemplary compounds represented by formula (XVIII), m is 1 or 2; n is 1 or 2; R1 , R2 , R4 , R6 , R11 , R15 , and R16 are H; R3 is -OSO3- ; R7 is OH; R12 is H or OH; R17 is methyl ; and R19 is a haloalkyl, for example, -CH2F . In one embodiment, a compound represented by formula (XVIII) is represented by formula (XVIII-a): During the ceremony: R 18 is independently H, a substituted or unsubstituted alkyl, a substituted or unsubstituted heteroalkyl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocycloalkyl, a substituted or unsubstituted aryl, or a substituted or unsubstituted heteroaryl; and R 19 is alkyl, haloalkyl, alkenyl, or alkynyl. It is represented as or a pharmaceutically acceptable salt thereof. In one embodiment, R 18 is H and R 19 is a haloalkyl (e.g., -CH₂F ). In one embodiment, a compound represented by formula (XVIII-a) is represented by formula (XVIII-a'): During the ceremony: R 19 is alkyl, haloalkyl, alkenyl, or alkynyl. It is represented by or a pharmaceutically acceptable salt thereof. In one embodiment, R 19 is a haloalkyl (e.g., -CH₂F ). In one embodiment, a compound represented by formula (XVIII) is represented by formula (XVIII-b): During the ceremony: R 18 is independently H, a substituted or unsubstituted alkyl, a substituted or unsubstituted heteroalkyl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocycloalkyl, a substituted or unsubstituted aryl, or a substituted or unsubstituted heteroaryl; and R 19 is alkyl, haloalkyl, alkenyl, or alkynyl. It is represented by or a pharmaceutically acceptable salt thereof. In one embodiment, R 18 is H and R 19 is a haloalkyl (e.g., -CH₂F ).