JP-2022533991-A5 -

Dates

Publication Date

20230525

Application Date

20200520

Description

Furthermore, the peptide that is cyclized in part may be a peptide containing Asu. Here, Asu is aspartimide or aminosuccinimide . Furthermore, although the above-described examples have been the focus of this explanation, these are merely illustrative and do not limit the present invention. Those with ordinary skill in the art to which this invention belongs will understand that it can be applied to various modifications not illustrated, as long as they do not depart from the essential characteristics of these examples. For example, each component specifically shown in the examples can be modified and implemented. Moreover, any differences in such modifications and applications should be interpreted as being included within the scope of the present invention as defined in the claims. Another aspect of the present invention may be as follows: [1] A novel peptide compound represented by the following chemical formula 1 or a pharmaceutically acceptable salt thereof. In the aforementioned chemical formula 1, A1 to A5 are linked by peptide bonds represented by the following chemical formula 2. A1 is either substituted or unsubstituted proline or glutamine. A2 is substituted or unsubstituted glycine or aspartic acid. A3 is substituted or unsubstituted glutamine or glycine. A4 is substituted or unsubstituted aspartic acid or leucine. A5 is substituted or unsubstituted glycine or alanine. A1 to A5 may be independently substituted with any of the following, either 0 to 2 substituted or unsubstituted: glycine, alanine, serine, threonine, cysteine, valine, leucine, isoleucine, methionine, proline, phenylalanine, tyrosine, tryptophan, aspartic acid, glutamic acid, asparagine, glutamine, histidine, lysine, and arginine. ... (2) Here, B is either hydrogen or is linked to at least one of A1 to A5 to form a cyclization. [2] A novel peptide compound represented by the following chemical formula 3 or a pharmaceutically acceptable salt thereof. In the aforementioned chemical formula 3, A1 to A6 are linked by peptide bonds represented by the following chemical formula 2. A1 is a substituted or unsubstituted proline or glutamine. A2 is substituted or unsubstituted glycine or aspartic acid. A3 is substituted or unsubstituted glutamine or glycine. A4 is substituted or unsubstituted aspartic acid or leucine. A5 is substituted or unsubstituted glycine or alanine. A6 is substituted or unsubstituted leucine or glycine. A1 to A6 may be independently substituted with any of the following: glycine, alanine, serine, threonine, cysteine, valine, leucine, isoleucine, methionine, proline, phenylalanine, tyrosine, tryptophan, aspartic acid, glutamic acid, asparagine, glutamine, histidine, lysine, and arginine, with zero to two substitutions or unsubstituted units. ... (2) Here, B is either hydrogen or is cyclized by being linked to at least one of A1 to A6. [3] A novel peptide compound represented by the following chemical formula 4 or a pharmaceutically acceptable salt thereof. In the aforementioned chemical formula 4, A1 to A7 are linked by peptide bonds represented by the following chemical formula 2. A1 is a substituted or unsubstituted proline or glutamine. A2 is substituted or unsubstituted glycine or aspartic acid. A3 is substituted or unsubstituted glutamine or glycine. A4 is substituted or unsubstituted aspartic acid or leucine. A5 is substituted or unsubstituted glycine or alanine. A6 is substituted or unsubstituted leucine or glycine. A7 is either substituted or unsubstituted alanine or proline. Any one of A1 to A7 may be independently substituted with any of the following: glycine, alanine, serine, threonine, cysteine, valine, leucine, isoleucine, methionine, proline, phenylalanine, tyrosine, tryptophan, aspartic acid, glutamic acid, asparagine, glutamine, histidine, lysine, and arginine, with zero to three substitutions or unsubstituted units. ... (2) Here, B is either hydrogen or is linked to at least one of A1 to A7 to form a cyclization. [4] A novel peptide compound represented by the following chemical formula 5 or a pharmaceutically acceptable salt thereof. In the aforementioned chemical formula 5, A1 to A8 are linked by peptide bonds represented by the following chemical formula 2. A1 is a substituted or unsubstituted proline or glutamine. A2 is substituted or unsubstituted glycine or aspartic acid. A3 is substituted or unsubstituted glutamine or glycine. A4 is substituted or unsubstituted aspartic acid or leucine. A5 is substituted or unsubstituted glycine or alanine. A6 is substituted or unsubstituted leucine or glycine. A7 is either substituted or unsubstituted alanine or proline. A8 is substituted or un