JP-2022534501-A5 -

Dates

Publication Date

20230530

Application Date

20200527

Description

While the above text is described in some detail with figures and examples for clarity and understanding, it will be understood by those skilled in the art that numerous and varied modifications can be made without departing from the spirit of this disclosure. Therefore, it should be clearly understood that the forms disclosed herein are merely illustrative and not intended to limit the scope of this disclosure, but rather encompass all modifications and alternatives that are in line with the true scope and spirit of the invention. Another aspect of the present invention may be as follows: [1] Compounds of formula (I) having the following structure or pharmaceutically acceptable salts thereof: (In the formula: n is either 0 or 1; Z1 is -C(=O)-, -NH-C(=O)-, or -O-C(=O)-; R1 is selected from the group consisting of arbitrarily substituted aryls, arbitrarily substituted heteroaryls, arbitrarily substituted heterocyclines, arbitrarily substituted aryls (C1-4 alkyls ), arbitrarily substituted heteroaryls (C1-4 alkyls ), and arbitrarily substituted heterocyclines (C1-4 alkyls ); R2 and R3 are independently selected from the group consisting of hydrogen, unsubstituted C1-4 alkyl , unsubstituted C1-4 haloalkyl, optionally substituted aryl , optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted aryl (C1-4 alkyl ) , optionally substituted heteroaryl ( C1-4 alkyl), and optionally substituted heterocyclyl ( C1-4 alkyl); R4 and R5 are independently selected from the group consisting of hydrogen, unsubstituted C1-4 alkyl , unsubstituted C1-4 haloalkyl, optionally substituted aryl , optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted aryl (C1-4 alkyl ) , optionally substituted heteroaryl ( C1-4 alkyl), and optionally substituted heterocyclyl ( C1-4 alkyl); R6 and R7 are independently selected from the group consisting of hydrogen , unsubstituted C1-4 alkyl , and unsubstituted C1-4 haloalkyl ; R 8 is selected from the group consisting of hydrogen, unsubstituted C1-4 alkyl , unsubstituted C2-4 alkenyl, unsubstituted C2-4 alkynyl, unsubstituted C1-4 haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl , optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted cycloalkyl (C1-4 alkyl), optionally substituted cycloalkenyl ( C1-4 alkyl), optionally substituted aryl (C1-4 alkyl) , optionally substituted heteroaryl ( C1-4 alkyl) , optionally substituted heterocyclyl ( C1-4 alkyl) , optionally substituted N-amide, optionally substituted N-sulfonamide, -NR 10 R 11 , and -C ( =O)NR 12 R 13 ; R9 is selected from the group consisting of hydrogen, unsubstituted C1-4 alkyl , optionally substituted monocyclic C4-6 cycloalkyl , optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted aryl (C1-4 alkyl ), optionally substituted heteroaryl (C1-4 alkyl ), and optionally substituted heterocyclyl (C1-4 alkyl ); R10 and R12 are independently hydrogen or unsubstituted C1-4 alkyl groups ; R11 and R13 are independently selected from the group consisting of hydrogen, unsubstituted C1-4 alkyl , unsubstituted C1-4 haloalkyl, optionally substituted cycloalkyl , optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted cycloalkyl (C1-4 alkyl ), optionally substituted cycloalkenyl (C1-4 alkyl ), optionally substituted aryl (C1-4 alkyl) , optionally substituted heteroaryl ( C1-4 alkyl), and optionally substituted heterocyclyl (C1-4 alkyl ); or, R10 and R11 , together with the nitrogen to which R10 and R11 are bound, form optionally substituted 4- to 8-membered monocyclic heterocyclines, optionally substituted 8- to 13-membered condensed bicyclic heterocyclines, or optionally substituted 7- to 13-membered spiro-dicyclic heterocyclines; R12 and R13 , together with the nitrogen to which R12 and R13 are bound, form optionally substituted 4- to 8-membered monocyclic heterocyclines, optionally substituted 8- to 13-membered condensed bicyclic heterocyclines, or optionally substituted 7- to 13-membered spiro-dicyclic heterocyclines; R2 and R3 , together with the carbon to which R2 and R3 are bonded , form optionally substituted monocyclic C3-6 cycloalkyl groups or optionally substituted 3-6 membered monocyclic heterocyclines; or, R4 and R5 , together with the carbon to which R4 and R5 are bonded , form optionally substituted monocyclic C3-6 cycloalkyl groups or optionally substituted 3-6 membered monocyclic heterocyclines; or, R2 and R4 , together with the carbon to which R2 and R4 are each bonded, optionally form a monocyclic C5-7 cycloalkyl or an optionally substituted 5-7 membered monocyclic heterocycline; or, R3 and R5 , together with the carbon to which