JP-2025514306-A5 -

Dates

Publication Date

20260511

Application Date

20230428

Description

Although the aforementioned invention has been described in some detail as an example and illustration for the purpose of clarifying understanding, it will be clear that certain changes and modifications may be implemented within the scope of the attached claims. The present invention provides, for example, the following items: (Item 1) A structurally modified ascaoside, a) an ascaloside-based oligomer or polymer comprising two or more ascaloside moieties, and optionally comprising a linker moiety between adjacent ascaloside moieties, b) Oligomer or polymer-functionalized ascalosides comprising an ascaloside moiety, wherein one, two, or three oligomers or polymers are bonded to the ascaloside moiety, and c) The structurally modified askaloside selected from the group consisting of askaloside pendant polymers, wherein the askaloside pendant polymer comprises a polymer, with one or more pendant askaloside portions bonded to the polymer, and optionally including a linker portion between the polymer and the pendant askaloside portions. (Item 2) The structurally modified askaloside according to item 1, wherein the modified askaloside is the askaloside-based oligomer or polymer, and the oligomer or polymer comprises two or more askaloside portions that do not have a linker portion between adjacent askaloside portions. (Item 3) The structurally modified askaloside according to item 2, wherein the adjacent askaloside portions are bonded to each other via ester bonds formed from a hydroxyl group on the first askaloside molecule and a carboxylic acid on the second askaloside molecule. (Item 4) The structurally modified askaloside according to item 1, wherein the modified askaloside is the askaloside-based oligomer or polymer, and the oligomer or polymer comprises two or more askaloside moieties having a linker moiety between adjacent askaloside moieties. (Item 5) The structurally modified ascaloside according to item 4, wherein the linker portion is selected from the group consisting of ether, ester, amide, glycoside, urethane, carbonate, and siloxane portions. (Item 6) The structurally modified ascaloside according to any one of items 1 to 5, wherein the modified ascaloside is the ascaloside-based oligomer or polymer, and the oligomer or polymer contains 2 to 1,000 ascaloside moieties. (Item 7) The structurally modified ascaloside described in item 6, wherein the oligomer or polymer contains 2 to 500 ascaloside moieties. (Item 8) The structurally modified ascaloside described in item 6, wherein the oligomer or polymer contains 2 to 100 ascaloside moieties. (Item 9) The structurally modified ascaloside described in item 6, wherein the oligomer or polymer comprises 2 to 10 ascaloside moieties. (Item 10) The structurally modified ascaloside according to item 6, wherein the oligomer or polymer comprises at least 10 ascaloside moieties. (Item 11) The structurally modified ascaloside according to item 6, wherein the oligomer or polymer comprises at least 20 ascaloside moieties. (Item 12) The structurally modified ascaloside according to item 6, wherein the oligomer or polymer comprises at least 50 ascaloside moieties. (Item 13) The structurally modified ascaloside according to item 1, wherein the modified ascaloside is the oligomer or polymer-functionalized ascaloside, and the oligomer or polymer-functionalized ascaloside comprises one oligomer or polymer bonded to the ascaloside. (Item 14) The structurally modified ascaloside according to item 1, wherein the modified ascaloside is the oligomer or polymer-functionalized ascaloside, and the oligomer or polymer-functionalized ascaloside comprises two oligomers or polymers bonded to the ascaloside. (Item 15) The structurally modified ascaloside according to item 1, wherein the modified ascaloside is the oligomer or polymer-functionalized ascaloside, and the oligomer or polymer-functionalized ascaloside comprises three oligomers or polymers bonded to the ascaloside. (Item 16) The above-mentioned oligomer or polymer comprises a biodegradable polymer, and is a structurally modified ascaloside according to any one of items 13 to 15. (Item 17) A structurally modified ascaloside according to any one of items 13 to 15, wherein the oligomer or polymer is selected from the group consisting of chitosan, chitin, starch, lignin, agar, pectin, cellulose, other polysaccharides (e.g., bark, sawdust, other cellulose waste), poly(ethylene glycol), poly(caprolactone), poly(lactide), poly(glycolic acid), polybutylene, poly(vinyl alcohol), poly(vinyl chloride), poly(citric acid), poly(acrylate), poly(aspartic acid), poly(ethylene), polyethylene vinyl acetate (PEVA), polystyrene, divinylbenzene, and their derivatives and copolymers. (Item 18) The structurally modified ascaloside according to item 1, wherein the modified ascaloside is the ascaloside pendant polymer, and the ascaloside pendant polymer contains about 5 to about 500 pendant ascaloside portions bonded to the ascaloside pendant polyme