JP-2025515483-A5 -

Dates

Publication Date

20260511

Application Date

20230428

Description

Apparatus 26. The disease is cancer, preferably breast cancer, lung cancer, pancreatic cancer, prostate cancer, bone cancer, liver cancer,The method according to embodiment 25, selected from and endometrial cancer.The present invention provides, for example, the following items:(Item 1)Compound of formula (I):or its N-oxide, its pharmaceutically acceptable salt, its stereoisomer, its tautomer, its deuterated analog, or its prodrug,During the ceremony,The ring CyA is a 3- to 8-membered ring, and the ring contains, as ring members (or more), 0, 1, or 2 heteroatoms (or more) independently selected from nitrogen, oxygen, or optionally oxidized sulfur, and the ring has at least one substituent R10It is optionally replaced by,n is 0, 1, 2, 3, 4, or 5,m is 0 or 1, however, when m = 0, the wholeThe condition is that the part is replaced by H,R1However, H, halogen, -C1-8Alkyl, -C2-8Alkenyl, -C2-8Alkynyl, cycloalkyl, haloalkyl, heterocyclyl, aryl, heteroaryl, -CN, -OR1a, -COR1a, -CO2R1a, -CONR1aR1b, -NR1aR1b, -NR1aCOR1b, -NR1aCO2R1b, or -NR1aCONR1bR1cAnd the above-C1-8Alkyl, the above-C2-8Alkenyl, the above-C2-8Each of the alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl has at least one substituent R1dIt is optionally replaced by,R1a, R1b, and R1cHowever, each independently, hydrogen, -C1-8Selected from alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, the -C1-8Alkyl, the above-C2-8Alkenyl, the above-C2-8Each of the alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl has at least one substituent R1st floorIt is optionally replaced by,R1dand R1st floorHowever, each independently, hydrogen, halogen, hydroxyl, and -C1-8Alkyl, -halo C1-8Alkyl, -C1-8Alkoxy, -C2-8Alkenyl, -C2-8Selected from alkynyl, cycloalkyl, halocycloalkyl, heterocyclyl, haloheterocyclyl, aryl, haloaryl, heteroaryl, or haloheteroaryl, and the -C1-8Alkyl, the above-mentioned -halo C1-8Alkyl, the above-C1-8Alkoxy, the above-C2-8Alkenyl, the above-C2-8Each of the alkynyl, cycloalkyl, halocycloalkyl, heterocyclyl, haloheterocyclyl, aryl, haloaryl, heteroaryl, or haloheteroaryl is a halogen, hydroxyl, -C1-8Alkyl, -halo C1-8Alkyl, -C1-8Alkoxy, -halo C1-8Alkoxy, -C2-8Alkenyl, -C2-8Optionally substituted with at least one substituent selected from the group consisting of alkynyl, cycloalkyl, halocycloalkyl, heterocyclyl, haloheterocyclyl, aryl, haloaryl, heteroaryl, or haloheteroaryl,R2However, hydrogen, halogen, -C1-8Alkyl, -C2-8Alkenyl, -C2-8Alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, oxo, -CN, -OR2a, -SO2R2a, -SO2NR2aR2b, -COR2a, -CO2R2a, -CONR2aR2b, -NR2aR2b, -NR2aCOR2b, -NR2aCO2R2b, -NR2aCONR2bR2c, or -NR2aSO2R2bAnd the above-C1-8Alkyl, the above-C2-8Alkenyl, the above-C2-8Each of the alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl has at least one substituent R2dIt is optionally replaced by R2a, R2b, and R2cHowever, each independently, hydrogen, -C1-8Alkyl, -C2-8Alkenyl, -C2-8Selected from alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, the -C1-8Alkyl, the above-C2-8Alkenyl, the above-C2-8Each of the alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl has at least one substituent R2FIt is optionally replaced by,(R2aand R2b), (R2band R2c), or (R2aand R2c) together with the atom(s) to which they are bonded, form a 3- to 12-membered ring, wherein the ring(s) independently contain 0, 1, or 2 heteroatoms(s) selected from nitrogen, oxygen, or optionally oxidized sulfur as ring members, and the ring(s) contain at least one substituent R2FIt is optionally replaced by,R2dand R2FHowever, each independently, hydrogen, halogen, and -C1-8Alkyl, -C2-8Alkenyl, -C2-8Alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, oxo, -CN, -OR2g, -SO2R2g, -SO2NR2gR2h, -COR2g, -CO2R2g, -CONR2gR2h, -NO2, -NR2gR2h, -NR2gCOR2h, -NR2gCO2R2h, -NR2gCONR2hR2i, or -NR2gSO2R2hSelected from, the above-C1-8Alkyl, the above-C2-8Alkenyl, the above-C2-8Each of the alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is a halogen, hydroxy, oxo, or -C1-8Alkyl, -halo C1-8Alkyl, -C1-8Alkoxy, -halo C1-8Alkoxy, -C2-8Alkenyl, -C2-8They are optionally substituted with at least one substituent selected from the group consisting of alkynyl, cycloalkyl, halocycloalkyl, heterocyclyl, haloheterocyclyl, aryl, haloaryl, heteroaryl, or haloheteroaryl, or(2 R2d) and/or (two R2F) together with the atoms (or more) to which they are bonded, form a 3- to 12-membered ring, wherein the ring contains, as ring members (or more), 0, 1, or 2 heteroatoms (or more) independently selected from nitrogen, oxygen, or optionally oxidized sulfur, and the ring contains halogen, hydroxyl, oxo, -C1-8Alkyl, -halo C1-8Alkyl, -C(O)C1-8Alkyl, -C1-8Alkoxy, -halo C1-8Alkoxy, -C2-8Alkenyl, -C2-8Optionally substituted with at least one substituent selected from the group consisting of alkynyl, cycloalkyl, halocycloalkyl, heterocyclyl, haloheterocyclyl, aryl, haloaryl, heteroaryl, or haloheteroaryl,R2g, R2h, and R2iHowever, each independently, hydrogen, -C1-8Alkyl, -C2-8Alkenyl, -C2-8Selected from alk