JP-2025517642-A5 -

Dates

Publication Date

20260507

Application Date

20230504

Description

[Invention 1001]Equation (I):A compound of or a pharmaceutically acceptable salt thereof, wherein the formula isRing A is,(a) Raand RbEach of the 1 to 6 substituents independently selected from the group consisting of C may be optionally substituted.3-15Cycloalkylene or 3-15 member heterocyclylene,(b) Raand RbPhenylene or 5-6 member heteroarylene, each optionally substituted with 1 to 3 substituents independently selected from the group consisting of the above.Selected from the group consisting of,R1teeth,(a) C(O)OH and(b) C(O)NRdReand,(c) C(O)OC1-6Alkyl, and the C1-6Alkyl groups: 1 to 3 RcC(O)OC may be optionally substituted with1-6Alkyl andSelected from the group consisting of,Each R2, R3, R4, and R5These are independently: Halo, CN, C1-3Alkyl, C1-3Haloalkyl, C1-3Alkoxy, C1-3Haloalkoxy, OH, and NRdReSelected from the group consisting of,m2 is 0, 1, or 2.m3 and m4 are independently 0, 1, 2, or 3.m5 is 0, 1, 2, 3, or 4.L is -(LA)n1- and in the formula, LAAnd n1 is defined according to (AA) or (BB),(AA)n1 is an integer between 3 and 15.Each LAIndependently, LA1, LA3, and LA4Selected from the group consisting of, however, LAThe appearance of 1 to 3 of them is LA4Let it be so,(BB)n1 is an integer between 0 and 20.Each LAIndependently, LA1and LA3Selected from the group consisting of,Each LA1It is independently, -CH2-----CHRL-, and -C(RL)2- Selected from the group consisting of,Each LA3Independently, -N(R)d)-,-N(Rb)-, -O-, -S(O)0-2-, and selected from the group consisting of C (=O),Each LA4Independently,(a) Raand RbEach of the 1 to 6 substituents independently selected from the group consisting of C may be optionally substituted.3-15Cycloalkylene or 3-15 member heterocyclylene,(b) Raand RbEach of the 1 to 6 substituents independently selected from the group consisting of C may be optionally substituted.6-15Arirene or 5-15 member heteroarireneSelected from the group consisting of,However, L is N-O, O-O, N-N, N-S(O)0, and O-S(O)0-2It shall not contain any of the following bonds:In the formula, each RLThese are independently: halo, cyano, -OH, and -C1-6Alkoxy and -C1-6Haloalkoxy and -NRdReAnd, C(=O)N(Rf)2And, S(O)0-2(C1-6Alkyl) and S(O)0-2(C1-6Haloalkyl) and S(O)1-2N(R)f)2And, -Rband 1 to 6 RcC may be optionally replaced by1-6Selected from the group consisting of alkyls,Ring C is,Selected from the group consisting of,c1 is 0, 1, 2, or 3.Each RYRaand RbIndependently selected from the group consisting of,RaNis either H or 1 to 3 RcC may be optionally replaced by1-6It is alkyl,Y1and Y2These are independently N, CH, or CRYAnd,yy represents the connection point to L,X is CH, C, or N.The aforementionedIt is either a single bond or a double bond.LCThe bond is -CH2-----CHRa-, -C(Ra)2-, -N(Rd) - and O are selected from the group, provided that X is N, LCThe value must be something other than O.Each RaIndependently,(a) Hello,(b) Cyano,(c)-OH,(d) Oxo,(e)-C1-6Alkoxy,(f) - C1-6Haloalkoxy,(g)-NRdRe,(h)C(=O)C1-6Alkyl,(i) C(=O)C1-6Haloalkyl,(j)C(=O)OH,(k)C(=O)OC1-6Alkyl,(l)C(=O)OC1-6Haloalkyl,(m)C(=O)N(Rf)2,(n) S(O)0-2(C1-6Alkyl),(o)S(O)0-2(C1-6Haloalkyl),(p)S(O)1-2N(R)f)2, and(q) 1 to 6 RcEach of these may be optionally substituted, C1-6Alkyl, C2-6Alkenyl, or C2-6AlkinylSelected from the group consisting of,Each Rbis, -(Lb)b-Rb1and -Rb1Independently selected from the group consisting of, in the formula,Each b is independently 1, 2, or 3.Each -LbThese are independently -O-, -N(H)-, and -N(C)1-3Alkyl)-,-S(O)0-2-, C (=O), and C1-3Selected from the group consisting of alkylenes,Each Rb1C3-10Cycloalkyl, 4-10 membered heterocyclyl, C6-10Independently selected from the group consisting of aryls and 5- to 10-membered heteroaryls, each of which has 1 to 3 RgIt may be optionally replaced by,Each RcThese are halo, cyano, -OH, and -C.1-6Alkoxy, -C1-6Haloalkoxy, -NRdRe, C(=O)C1-6Alkyl, C(=O)C1-6Haloalkyl, C(=O)OC1-6Alkyl, C(=O)OC1-6Haloalkyl, C(=O)OH, C(=O)N(R)f)2, S(O)0-2(C1-6Alkyl), S(O)0-2(C1-6Haloalkyl), and S(O)1-2N(R)f)2Independently selected from the group consisting of,Each Rdand ReThese are H and C(=O)C, independently of each other.1-6Alkyl and C(=O)C1-6Haloalkyl and C(=O)OC1-6Alkyl and C(=O)OC1-6Haloalkyl and C(=O)N(R)f)2And, S(O)1-2(C1-6Alkyl) and S(O)1-2(C1-6Haloalkyl) and S(O)1-2N(R)f)2and 1 to 3 RhC may be optionally replaced by1-6Selected from the group consisting of alkyls,Each RfH and 1 to 3 RhC may be optionally replaced by1-6Independently selected from the group consisting of alkyls,Each RgR is independent of Rh, C1-3Alkyl and C1-3Selected from the group consisting of haloalkyls,Each RhThese are independently halo, cyano, -OH, and -C.1-6Alkoxy, -C1-6Haloalkoxy, -NH2, -N(H)(C1-3Alkyl), and -N(C1-3Alkyl)2Selected from the group consisting of,The aforementioned compound or a pharmaceutically acceptable salt thereof.[Invention 1002]Ring A has 1 to 3 RaThe compound of the present invention 1001, which is phenylene that may be optionally substituted.[Invention 1003]Ring A isIn the formula, aa represents the connection point to L,