JP-2026074447-A - Tablets and methods for improving their retronasal aroma

Abstract

[Problem] To provide a tablet that can improve retronasal aroma. [Solution] An oral or mouth-use tablet containing an ester-based fragrance and having a disintegration time of less than 9 minutes. The tablet is preferably a chewable tablet. [Selection Diagram] None

Inventors

• 冨田 慎介
• 山田 和哉
• 滝口 景介

Assignees

• 三生医薬株式会社

Dates

Publication Date

20260507

Application Date

20241021

Claims (7)

1. Oral or oral tablets containing ester-based fragrances and having a disintegration time of less than 9 minutes.
2. The tablet according to claim 1, wherein the tablet is an orally disintegrating tablet or a chewable tablet.
3. The tablet according to claim 1 or 2, wherein the amount of the ester-based fragrance added is 0.05 to 1.8% by mass relative to the total mass of the added ingredients.
4. Furthermore, the tablet according to claim 1 or 2 contains crystalline cellulose.
5. A method for improving the retronasal aroma of oral or osmotic tablets containing ester-based fragrances by adjusting the disintegration time to less than 9 minutes.
6. The method according to claim 5, wherein the amount of the ester-based fragrance added to the tablet is 0.05 to 1.8% by mass relative to the total mass of the added components.
7. The method according to claim 5 or 6, wherein the tablet contains crystalline cellulose.

Description

This invention relates to tablets and a method for improving their retronasal aroma. The aromas of food products are classified into two types: those that can be perceived solely through the nose without consuming the product (orthonasal aromas), and those that escape from the oral cavity into the nasal cavity after consumption (retronasal aromas). Improving retronasal aromas can lead to an increase in the product value of food products. In response to this, several methods have been proposed to improve retronasal aroma. For example, Patent Document 1 discloses a retronasal aroma enhancer containing a specific dipeptide (γ-Glu-Abu, γ-glutamyl-2-aminobutyric acid). Patent Document 2 confirms through sensory evaluation that adding rotundone, a citrus flavor enhancer, to orange-flavored gum enhances the retronasal aroma. On the other hand, orally disintegrating tablets and chewable tablets are known as one form of food, pharmaceutical, and oral care product formulations. These formulations are tablets used by contact with moisture and/or chewing in the oral cavity. Orally disintegrating tablets and chewable tablets containing flavoring components are also known (see Patent Documents 3 and 4). Japanese Patent Publication No. 2020-191818Japanese Patent Publication No. 2016-198025International Publication No. 99/27901 PamphletJapanese Patent Publication No. 2005-272401 [1. About Tablets] First, the composition and properties of the tablets of the present invention will be described. The tablets of the present invention contain an ester-based fragrance and may further contain any other components. [1-1. Fragrance] The tablets of the present invention contain an ester-based fragrance. The ester-based fragrance is not particularly limited as long as it is an ester, but examples include formic acid esters, aliphatic carboxylic acid esters, aromatic carboxylic acid esters, and cyclic esters. Examples of the above-mentioned formic acid esters include propyl formate, isobutyl formate, cis-3-hexenyl formate, and terpinyl formate. Examples of the above aliphatic carboxylic acid esters include benzyl lactate, ethyl acetate, isoamyl acetate, hexyl acetate, octyl acetate, nonyl acetate, decyl acetate, dodecyl acetate, dihydromyrcenyl acetate, linalyl acetate, citronellyl acetate, geranyl acetate, neryl acetate, tetrahydromugol acetate, lavandulyl acetate, nerolidol acetate, dihydrocuminyl acetate, terpinyl acetate, citriyl acetate, nopyl acetate, dihydroterpinyl acetate, trans-2-hexenyl acetate, 2,4-dimethyl-3-cyclohexenylmethyl acetate, miraldyl acetate, beticol acetate, butyl propionate, hexyl propionate, decenyl propionate, linalyl propionate, methyl butyrate, ethyl butyrate, amyl butyrate, Examples include isoamyl butyrate, hexyl butyrate, octyl butyrate, cinnamyl butyrate, isopropyl isobutyrate, octyl isobutyrate, linalyl isobutyrate, hexyl methylbutyrate, cis-3-hexenyl methylbutyrate, allyl 2-ethylbutyrate, ethyl 3-hydroxybutyrate, pentyl valerate, 2-methylpentyl 2-methylvalerate, ethyl hexanoate, 2-methylbutyl hexanoate, hexyl hexanoate, methyl 3-hydroxyhexanoate, methyl octanoate, ethyl octanoate, methyl nonanoate, ethyl nonanoate, ethyl decanoate, methyl undecylenate, isoprenyl angelicate, methyl geranate, triethyl citrate, ethyl acetoacetate, ethyl 2-hexylacetoacetate, and ethyl 2,4-decadienate. Examples of the above aromatic carboxylic acid esters include linalyl benzoate, methyl salicylate, methyl cinnamate, ethyl benzylacetoate, methyl anthranilate, ethyl N-methylanthranilate, and ethyl methylphenylglycidate (such as ethyl 3-methyl-3-phenylglycidate). Examples of the above cyclic esters include sotolon, coumarin, jasmin lactone, and γ-jasmolactone. The ester-based fragrance may be a synthetic fragrance, a naturally derived fragrance, or a blended fragrance, fragrance composition, essential oil, etc. In the tablets of the present invention, the ester-based fragrance is preferably a C2-C14 ester. Furthermore, ester-based fragrances may be included in tablets as powdered fragrances. Using powdered fragrances makes them easier to handle as raw materials for tablet formulation, even if the fragrance is liquid at room temperature, and also improves the storage stability and heat resistance of the fragrance. Powdered fragrances may be obtained by emulsifying the fragrance with an excipient and then spray-drying it to produce a powder, or by supporting the fragrance on a carrier. Examples of excipients include dextrin, starch, gum arabic, gelatin, and casein. Examples of carriers include powdered silica, powdered calcium silicate, and cellulose particles. The fragrance content in the powdered fragrance is usually 1 to 50% by mass, preferably 3 to 40% by mass, and particularly preferably 5 to 30% by mass. Ester-based fragrances may be used individually or in combination of two or more types. The lower limit of the proportion of ester-based flavoring in tablets is preferably 0.05% by mass, more preferably 0.10% by mass, a