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JP-2026076046-A - Apparatus, method, and program

JP2026076046AJP 2026076046 AJP2026076046 AJP 2026076046AJP-2026076046-A

Abstract

[Problem] To provide a culture apparatus, method, and program. [Solution] An apparatus is provided comprising: an acquisition unit that acquires cell information relating to cells cultured in a first culture and culture information indicating the culture conditions of the first culture; and an estimation unit that estimates the state of the culture medium after the first culture has been performed based on the cell information and the culture information, wherein the acquisition unit further acquires post-treatment information indicating the conditions of post-treatment performed on the culture medium after the first culture has been performed, and the estimation unit estimates the state of the culture medium after the first culture and post-treatment have been performed based on the cell information, the culture information and the post-treatment information. [Selection Diagram] Figure 1

Inventors

  • 茂木 豪介

Assignees

  • 横河電機株式会社

Dates

Publication Date
20260511
Application Date
20241023

Claims (14)

  1. An acquisition unit that acquires cell information relating to the cells cultured in the first culture and culture information indicating the culture conditions of the first culture, An estimation unit that estimates the state of the culture medium after the first culture has been performed based on the cell information and the culture information, A device equipped with the following features.
  2. The acquisition unit further acquires post-treatment information indicating the conditions for post-treatment performed on the culture medium after the first culture has been carried out. The apparatus according to claim 1, wherein the estimation unit estimates the state of the culture medium after the first culture and the post-processing have been performed, based on the cell information, the culture information, and the post-processing information.
  3. The apparatus according to claim 1 or 2, wherein the state of the culture medium includes the content of at least one component contained in the culture medium.
  4. The apparatus according to claim 1, wherein the estimation unit performs estimation using an estimation model that outputs state information indicating the state of the culture medium in response to the input of the cell information and culture information acquired by the acquisition unit.
  5. The apparatus according to claim 4, wherein the estimation model is a trained model using training data that includes cell information about cultured cells, culture information indicating the culture conditions applied in the culture of said cells, and information on the state of the culture medium after said culture.
  6. For each cell being cultured, there is a first memory unit that stores the predetermined initial state of the culture medium, A determination unit determines, based on the state of the culture medium estimated by the estimation unit and the contents stored by the first storage unit, at least one of the cells to be cultured in the second culture using the culture medium after the first culture, and the contents of the pretreatment to be performed on the culture medium before the start of the second culture. An output unit that outputs the decision content made by the aforementioned decision unit, The apparatus according to claim 1, further comprising:
  7. The apparatus according to claim 6, wherein the determination unit determines, from among a plurality of initial states stored in the first storage unit, the cell corresponding to the initial state closest to the state of the culture medium estimated by the estimation unit, as the cell to be cultured in the second culture.
  8. The apparatus according to claim 6, wherein the determination unit determines the content of the pretreatment based on the difference between the state of the culture medium estimated by the estimation unit and the initial state stored in the first storage unit in correspondence with the cells to be cultured in the second culture.
  9. The system further includes a second storage unit that stores materials that can be used in the treatment solution for each type of treatment applied to the culture medium before cultivation. The apparatus according to claim 8, wherein the determination unit further determines the material to be used in the pre-treatment solution determined based on the contents stored by the second storage unit.
  10. The apparatus according to claim 8, further comprising a generation unit that generates a pre-treatment solution in response to an approval operation performed by the user regarding the contents of the pre-treatment output by the output unit.
  11. The acquisition unit is, A language model unit that obtains natural language input sentences from the user, generates output sentences in natural language corresponding to those input sentences, and outputs them to the user; A specification unit that identifies the contents of the cell information and culture information from the content of the interaction with the user by the language model unit, The apparatus according to claim 1, having the following features.
  12. The apparatus according to claim 11, wherein the language modeling unit asks the user questions about items from a predetermined set of items necessary for identifying the contents of the cell information and culture information, for which information has not yet been obtained through dialogue.
  13. An acquisition step is to acquire cell information relating to the cells cultured in the first culture and culture information indicating the culture conditions of the first culture. An estimation step in which the state of the culture medium after the first culture is performed is estimated based on the cell information and the culture information, A method for providing this.
  14. By being executed by a computer, the computer will An acquisition unit that acquires cell information relating to the cells cultured in the first culture and culture information indicating the culture conditions of the first culture, A program that functions as an estimation unit that estimates the state of the culture medium after the first culture has been performed, based on the cell information and the culture information.

Description

This invention relates to an apparatus, method, and program. Patent Document 1, etc., states that "a composition containing a culture medium after the cultivation of animal cells, used for culturing algae, may be used that has been adjusted to the osmotic pressure of a standard culture medium for algae. The adjustment of osmotic pressure is done by measuring and adjusting the osmotic pressure before culturing the algae..." (paragraph 0023 of Patent Document 1). [Prior art documents] [Patent Documents] [Patent Document 1] Japanese Patent No. 7288725 [Non-Patent Document 1] Ciara D. Lynch et al., "Conversion of mammalian cell culture media waste to microbial fermentation feed efficiently supports production of recombinant protein by Escherichia coli," March 4, 2022, Internet <URL <https://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0266921> In a first embodiment of the present invention, an apparatus is provided comprising: an acquisition unit that acquires cell information relating to cells cultured in a first culture and culture information indicating the culture conditions of the first culture; and an estimation unit that estimates the state of the culture medium after the first culture has been performed based on the cell information and the culture information. In the above-described apparatus, the acquisition unit may further acquire post-treatment information indicating the conditions for post-treatment performed on the culture medium after the first culture, and the estimation unit may estimate the state of the culture medium after the first culture and post-treatment based on the cell information, culture information, and post-treatment information. In any of the above-described apparatuses, the state of the culture medium may include the content of at least one component contained in the culture medium. In any of the above-described devices, the estimation unit may perform estimation using an estimation model that outputs state information indicating the state of the culture medium in response to the input of the cell information and culture information acquired by the acquisition unit. In the above-described apparatus, the estimation model may be a pre-trained model using training data that includes cell information about cultured cells, culture information indicating the culture conditions applied during the cultivation of said cells, and information about the state of the culture medium after the cultivation. Any of the above devices may further include: a first storage unit that stores the predetermined initial state of the culture medium for each cell to be cultured; a determination unit that determines, based on the state of the culture medium estimated by the estimation unit and the contents stored by the first storage unit, at least one of the cells to be cultured in the second culture using the culture medium after the first culture, and the contents of the pretreatment to be performed on the culture medium before the start of the second culture; and an output unit that outputs the contents determined by the determination unit. In the above-described apparatus, the determination unit may determine, from among the multiple initial states stored in the first storage unit, the cell corresponding to the initial state closest to the state of the culture medium estimated by the estimation unit, as the cell to be cultured in the second culture. In any of the above-described apparatuses equipped with the determination unit, the determination unit may determine the content of the pretreatment based on the difference between the state of the culture medium estimated by the estimation unit and the initial state stored in the first storage unit in correspondence with the cells to be cultured in the second culture. The above-described apparatus further includes a second storage unit that stores materials usable in the treatment solution for each type of treatment applied to the culture medium before cultivation. The determination unit may further determine the materials to be used in the treatment solution for the determined pretreatment based on the contents stored in the second storage unit. Any of the above-described devices equipped with the second storage unit may further include a generation unit that generates the pre-processing solution in response to an approval operation performed by the user regarding the contents of the pre-processing output by the output unit. In any of the above-described devices, the acquisition unit may include a language model unit that acquires input sentences in natural language from the user, generates output sentences in natural language corresponding to the input sentences, and outputs them to the user; and an identification unit that identifies the contents of the cell information and culture information from the content of the interaction between the language model unit and the user. In the above-described device, the language model unit may