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JP-2026514281-A - Front subassembly for drug delivery device

JP2026514281AJP 2026514281 AJP2026514281 AJP 2026514281AJP-2026514281-A

Abstract

Front subassembly (103) for a drug delivery device (100) and a method for assembling the front subassembly and the drug delivery device, wherein the front subassembly includes a cap (200) having a distal cap opening and a proximal cap opening, and a device body (700) having a distal device body opening, the cap being held relative to the device body in a first cap position, and the front subassembly is configured such that the cap can move from a first cap position to a second cap position, the distal cap opening being further away from the distal device body opening along the longitudinal axis of the front subassembly in the first cap position than in the second cap position.

Inventors

  • ルウィーズ・ホジソン
  • トーマス・マーク・ケンプ
  • アンドリュー・ラバト－ロチェコウスト
  • ケヴィン・ラヌチ
  • ヒューゴー・リヴェラット
  • ウィリアム・ティミス

Assignees

  • サノフイ

Dates

Publication Date
20260508
Application Date
20231031
Priority Date
20221031

Claims (20)

  1. A front subassembly (103) for a drug delivery device (100), A cap (200) having a distal cap opening (208) and a proximal cap opening (206), A device body (700) having a proximal end and a distal end, comprising a device body (700) having a distal device body opening, The cap (200) is held in a first cap position relative to the device body (700), and the front subassembly (103) is configured such that the cap (200) can move from the first cap position to the second cap position. The distal cap opening (208) is located at the first cap position, further away from the distal device body opening along the longitudinal axis of the front subassembly (103) than at the second cap position, in the front subassembly (103).
  2. The front subassembly (103) according to claim 1, comprising a needle cover (500) at least partially disposed within the device body (700), wherein the axial position of the needle cover along the longitudinal axis relative to the device body is the same at the first cap position and the second cap position.
  3. The front subassembly (103) according to claim 2, wherein when the cap (200) is in the second cap position, the needle cover (500) is configured to be movable only axially relative to the device body (700), for example, in the proximal direction and/or away from the cap.
  4. The front subassembly (103) according to claim 2 or 3, comprising a needle cover locking mechanism (510, 720), the needle cover locking mechanism (510, 720) having a locked state and an unlocked state, wherein when the needle cover locking mechanism is in the locked state, the needle cover locking mechanism prevents movement of the needle cover (500) in the proximal direction along the longitudinal axis relative to the device body (700), and when the needle cover locking mechanism is in the unlocked state, movement in the proximal direction is permitted.
  5. The front sub-assembly (103) according to claim 4, wherein when the cap (200) is in the first cap position, the needle cover locking mechanism (510, 720) is in the locked state, and when the cap is in the second cap position, the needle cover locking mechanism is in the unlocked state.
  6. The front subassembly (103) according to claim 4 or 5, wherein the device body (700) includes a needle cover locking structure (720), and the needle cover (500) includes a flexible arm (510) that can move from a first radial position to a second radial position, and the needle cover locking mechanism (510, 720) is in the locked state when the flexible arm (510) is engaged with the needle cover locking structure (720) at the first radial position, and is in the unlocked state when the engagement between the flexible arm and the needle cover locking structure is released at the second radial position.
  7. The front subassembly (103) according to claim 6, wherein the cap (200) is configured to contact the flexible arm (510) during movement from the first cap position to the second cap position, thereby moving the flexible arm from the first radial position to the second radial position.
  8. The front subassembly (103) according to any one of claims 1 to 7, wherein the cap (200) includes a cap recess (213) having a distal recessed end (213.1) and a proximal recessed end (213.2).
  9. The front sub-assembly (103) according to claim 8, wherein the distal recessed end (213.1) contacts the flexible arm (510) at the second cap position.
  10. The front sub-assembly (103) according to claim 8, wherein the distal recessed end (213.1) does not contact the flexible arm (510) at the first cap position.
  11. The front sub-assembly (103) according to claim 8, wherein the distance between the distal recessed end (213.1) and the proximal recessed end (213.2) corresponds to the length of the flexible arm (510).
  12. The front subassembly (103) according to claim 8, wherein the distance between the distal recessed end (213.1) and the proximal recessed end (213.2) corresponds to the length of the path from the first cap position to the second cap position.
  13. The front subassembly (103) according to any one of claims 1 to 12, wherein the cap (200) includes at least one anti-rotation rib (205) extending in the longitudinal direction of the cap, and the length of the path from the first cap position to the second cap position corresponds to the length of the anti-rotation rib.
  14. The front subassembly (103) according to any one of claims 1 to 13, wherein the cap (200) is fixed to the device body (700) in a rotational direction when the cap is connected to the device body (700).
  15. The front subassembly (103) according to any one of claims 1 to 14, wherein the cap (200) is configured such that the distal cap opening (208) can be closed by a cap cover (300), and the cap cover is configured such that, when the cap cover is fitted onto the cap, the cap cover prevents the cap from moving from the first cap position to the second cap position.
  16. A drug delivery device (100) comprising a front subassembly (103) according to any one of claims 1 to 15.
  17. A drug delivery device (100) according to claim 16, comprising a container, wherein the container is pre-filled with a drug.
  18. A method for assembling a front subassembly (103) for a drug delivery device (100), - A step of inserting a needle cover spring (600) into a device body (700) having a distal device body opening, - The step of inserting the needle cover (500) into the device body, - A method comprising the step of attaching a cap (200) having a distal cap opening (208) and a proximal cap opening (206) to the device body at a first cap position, wherein the distal cap opening is located further along the longitudinal axis from the distal device body opening at the first cap position than a second cap position where the proximal cap opening is directly adjacent to the distal device body opening.
  19. A method for assembling the front subassembly (103) according to claim 18, wherein the axial position of the needle cover (500) along the longitudinal axis relative to the device body (700) is the same at the first cap position and the second cap position.
  20. A method for assembling a drug delivery device (100), - A step of providing a front subassembly (103) according to any one of claims 1 to 15, - A step of providing a rear subassembly (102) having a plunger holder (1200), a plunger (1000), and a preloaded drive spring (1100), wherein the plunger is releasably locked to the plunger holder, - The step of inserting the rear subassembly (102) into the front subassembly (103), - A step of moving the cap (200) from the first cap position to the second cap position, - A step of applying force to the needle cover (500) through the distal cap opening (208), thereby moving the needle cover in the proximal direction to release the plunger from the plunger holder and/or releasably locking the needle cover (500) onto the plunger (1000), A method comprising the step of closing the distal cap opening (208) by attaching a cap cover (300) to the cap (200).

Description

Many components of mass-produced handheld drug delivery devices are made of plastic. While the use of plastic components allows for cost-effective production, it also presents drawbacks. In particular, elastic plastic components that are subjected to pre-tension or maintained in a bent state against their restorative force can fatigue during long-term storage. Therefore, essential locking components may lose their original material properties during prolonged storage, potentially significantly impacting the functional reliability of the drug delivery device. Figure 1A-1D shows cross-sectional views of a drug delivery device in different operating states according to the first embodiment.This is an exploded view of an example of a drug delivery device, with or without an optional separate syringe holder.Any cap and any cap cover.Any cap and any cap cover.Any cap and any cap cover.Any cap and any cap cover.Any cap and any cap cover.Any cap and any cap cover.Any cap and any cap cover.Any cap and any cap cover.Any cap and any cap cover.These are perspective views and cross-sectional views of an arbitrary graba, respectively.These are perspective views and cross-sectional views of an arbitrary graba, respectively.This is an exemplary embodiment of a single sheet capable of forming a grabber carrier.This is a grabber that engages with the syringe needle shield.This is a grabber that engages with the syringe needle shield.This is a cutaway view of the grabber from the previous embodiment, assembled inside the cap.This details the interaction between grabber-holding bosses, for example, between the boss of a cap and the opening of an exemplary grabber.This is a cross-sectional view of the front end of an injection device having a fitted cap and a grabber mounted on the cap that interacts with the needle shield.This is any needle cover (needle shroud).This is the needle cover spring.This is a cross-sectional view of the needle cover spring assembled inside the drug delivery device in its pre-use state.This is the device itself.This is a cross-sectional view of the device itself.This is a perspective cross-sectional view of the distal end of the device body.This is a cross-sectional view of the central portion of the device body having a syringe holder.This is a perspective view of the syringe holder front stopper on the device body.This is a cross-sectional view of the distal end of the device body with the needle cover in the third cover position.This is a perspective view of the needle cover locking structure interacting with the flexible arm of the needle cover.Any syringe holder.A perspective view of any syringe holder.This is a detail diagram of a further exemplary embodiment of the flexible holder arm.This is an arbitrary syringe holder including the flexible holder arm shown in Figure 8C.Any pre-filled syringe.It's a plunger.This is the plunger release mechanism in its first state.This is the plunger release mechanism in its second state.This is the plunger release mechanism during the assembly of the drive subassembly.This is the plunger release mechanism during final assembly.This is a further state of the plunger release mechanism.This is a schematic diagram of the plunger release mechanism after the sleeve has been pushed into the retracted position.This is a schematic detail diagram of the plunger release mechanism after final assembly, before the sleeve is pushed in.This is a schematic detail diagram of the plunger release mechanism while the sleeve is being pushed in.This is a longitudinal rib located on the inside of the rigid arm of the drive spring holder.This is a perspective view of the plunger according to the second embodiment.This is a distal view of the plunger according to the second embodiment.This is a cross-sectional view along the radial direction through the shaft of the plunger according to the second embodiment.This is a cross-sectional view along the longitudinal direction through which the plunger shaft passes.This is a drive spring according to one embodiment of the present disclosure.This is the drive spring shown in Figure 11A, which is incorporated into the drug delivery device and operates the plunger.These are the drive springs shown in Figures 11A and 11B, which are assembled within the drug delivery device before the plunger is activated.This is a perspective view of the drive spring holder.This is a perspective view of the drive spring holder.This is a syringe return prevention mechanism.This is a cross-sectional view of the proximal portion of the drive spring holder.This is a different embodiment of the flexible portion of the drive spring holder.This is a different embodiment of the flexible portion of the drive spring holder.This is a different embodiment of the flexible portion of the drive spring holder.It is any audible indicator (clicker).An example is an indicator holder included on a drive spring holder.This is a perspective view of the support structure at the dis