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JP-2026514282-A - Assembly for drug delivery devices

JP2026514282AJP 2026514282 AJP2026514282 AJP 2026514282AJP-2026514282-A

Abstract

An assembly for a drug delivery device (100), comprising a device body (700) having a proximal and distal end, a needle cover (500) the needle cover (500) being movable relative to the device body (700) along a longitudinal axis, and a needle cover locking mechanism (720, 510) comprising at least one block element (720) the block element defining a block surface (720a), and at least one flexible arm (510) having a stop surface (510.1). The needle cover locking mechanism (720, 510) is configured to have a locked state, and the stop surface (510.1) and the block surface (720a) are arranged to cooperate to block the needle cover (500) from moving proximal along the longitudinal axis in the locked state of the needle cover locking mechanism (720, 510), and the assembly includes the needle cover locking mechanism (720, 510) and at least one flexible arm (510) which includes at least one projection (510.2) positioned distal to the stop surface (510.1).

Inventors

  • サイモン・フランシス・ブリアトン
  • ルウィーズ・ホジソン
  • トーマス・マーク・ケンプ
  • ケヴィン・ラヌチ
  • ヒューゴー・リヴェラット
  • ウィリアム・ティミス

Assignees

  • サノフイ

Dates

Publication Date
20260508
Application Date
20231031
Priority Date
20221031

Claims (20)

  1. An assembly for a drug delivery device (100), A device body (700) having a proximal end and a distal end, A needle cover (500), wherein the needle cover (500) is movable relative to the device body (700) along its longitudinal axis, Needle cover locking mechanism (720, 510), At least one block element (720), wherein the block element defines the block surface (720a), An assembly comprising at least one flexible arm (510) having a stop surface (510.1), wherein the needle cover locking mechanism (720, 510) is configured to have a locked state, the stop surface (510.1) and the block surface (720a) are arranged in cooperation to block the movement of the needle cover (500) proximal along the longitudinal axis in the locked state of the needle cover locking mechanism (720, 510), and the flexible arm (510) includes at least one projection (510.2) positioned distal to the stop surface (510.1), and the needle cover locking mechanism (720, 510).
  2. The assembly according to claim 1, wherein the angular spread of the stopping surface (510.1) is greater than the angular spread of the projection (510.2).
  3. The assembly according to claim 1 or 2, wherein the length of the projection (510.2) along the longitudinal axis is shorter than the length of the flexible arm (510).
  4. The assembly according to any one of claims 1 to 3, wherein the needle cover (500) is movable between an initial position (Z) and an intermediate position (X) with respect to the device body (700) along the longitudinal axis, the needle cover locking mechanism (720, 510) is in the locked state when the needle cover (500) is in the initial position (Z), and is in the unlocked state when the needle cover (500) is in the intermediate position (X), and the assembly is configured such that the block element (720) and the flexible arm (510) overlap radially during movement from the initial position (Z) to the intermediate position (X) and/or during movement from the intermediate position (X) to the initial position (Z).
  5. The assembly according to claim 4, wherein the needle cover (500) at the initial position (Z) is positioned more distal to the device body (700) along the longitudinal axis than at the intermediate position (X).
  6. The assembly according to claim 4 or 5, wherein, during movement from the intermediate position (X) to the initial position (Z), the flexible arm (510) is moved radially inward when the radial overlap between the block element (720) and the flexible arm (510) begins.
  7. The assembly according to any one of claims 1 to 6, wherein the block element (720) includes a block element recess, and the block element recess is configured to prevent twisting of the flexible arm (510) when the block element (720) and the flexible arm (510) overlap radially.
  8. The assembly according to claim 7, wherein the needle cover locking mechanism (720, 510) is configured such that the projection (510.2) is guided into the block element recess during movement from the intermediate position (X) to the initial position (Z).
  9. The assembly according to claim 7 or 8, wherein the block element (720) is intersected in the longitudinal direction by the block element recess.
  10. The assembly according to any one of claims 1 to 9, wherein the block element (720) defines two block surfaces (720a) that are angularly offset from each other, and the two block surfaces (720a) have the same axial position with respect to the device body (700).
  11. The assembly according to claim 7, 8, or 10, wherein the angular spread of the stop surface (510.1) corresponds to the angular spread between the two block surfaces (720a) and the block element recess.
  12. The assembly according to any one of claims 1 to 11, wherein the block element (720) has a ramp shape with a radially inward inclination.
  13. The assembly according to any one of claims 1 to 12, wherein the flexible arm (510) includes a hinge (510.3), and the projection (510.2) is positioned longitudinally between the hinge (510.3) and the stop surface (510.1).
  14. The assembly according to any one of claims 1 to 13, wherein the projection (510.2) and the stop surface (510.1) extend radially outward from the flexible arm (510).
  15. The assembly according to any one of claims 1 to 14, comprising two needle cover locking mechanisms (720, 510) positioned at the same axial location but angularly offset, for example, by 180 degrees.
  16. The assembly according to any one of claims 1 to 15, wherein the projection (510.2) is joined to the stop surface (510.1) by a T-joint.
  17. A drug delivery device (100) comprising the assembly described in any one of claims 1 to 16.
  18. A drug delivery device (100) according to claim 17, comprising a container, wherein the container is pre-filled with a drug.
  19. A method for delivering a drug from a drug delivery device, comprising using the drug delivery device described in claim 17 or 18.
  20. A drug for use in a method of treating a patient, wherein the method includes delivering the drug to the patient using a drug delivery device according to claim 17 or 18.

Description

Increased demand necessitates the mass production of portable drug delivery devices. Reducing manufacturing costs and increasing production speed remain ongoing challenges. Reducing the number of device components can both increase production speed and lower costs. However, this reduction in component count must be viewed critically. The absence of injury protection components, in particular, could lead to significant drawbacks. Figure 1A-1D shows cross-sectional views of a drug delivery device in different operating states according to the first embodiment.This is an exploded view of an example of a drug delivery device, with or without an optional separate syringe holder.Any cap and any cap cover.Any cap and any cap cover.Any cap and any cap cover.Any cap and any cap cover.Any cap and any cap cover.Any cap and any cap cover.Any cap and any cap cover.Any cap and any cap cover.Any cap and any cap cover.These are an oblique view and a cross-sectional view of an arbitrary graba, respectively.These are an oblique view and a cross-sectional view of an arbitrary graba, respectively.This is an exemplary embodiment of a single sheet capable of forming a grabber carrier.This is a grabber that engages with the syringe needle shield.This is a grabber that engages with the syringe needle shield.This is a cutaway view of the grabber from the previous embodiment, assembled inside the cap.This details the interaction between grabber-holding bosses, for example, between the boss of a cap and the opening of an exemplary grabber.This is a cross-sectional view of the front end of an injection device having a fitted cap and a grabber mounted on the cap that interacts with the needle shield.This is any needle cover (needle shroud).This is the needle cover spring.This is a cross-sectional view of the needle cover spring assembled inside the drug delivery device in its pre-use state.This is the device itself.This is a cross-sectional view of the device itself.This is a perspective cross-sectional view of the distal end of the device body.This is a cross-sectional view of the central portion of the device body having a syringe holder.This is a perspective view of the syringe holder front stopper on the device body.This is a cross-sectional view of the distal end of the device body with the needle cover in the third cover position.This is a perspective view of the needle cover locking structure interacting with the flexible arm of the needle cover.Any syringe holder.A perspective view of any syringe holder.This is a detail diagram of a further exemplary embodiment of the flexible holder arm.This is an arbitrary syringe holder including the flexible holder arm shown in Figure 8C.Any pre-filled syringe.It's a plunger.This is the plunger release mechanism in its first state.This is the plunger release mechanism in its second state.This is the plunger release mechanism during the assembly of the drive subassembly.This is the plunger release mechanism during final assembly.This is a further state of the plunger release mechanism.This is a schematic diagram of the plunger release mechanism after the sleeve has been pushed into the retracted position.This is a schematic detail diagram of the plunger release mechanism after final assembly, before the sleeve is pushed in.This is a schematic detail diagram of the plunger release mechanism while the sleeve is being pushed in.This is a longitudinal rib located on the inside of the rigid arm of the drive spring holder.This is a perspective view of the plunger according to the second embodiment.This is a distal view of the plunger according to the second embodiment.This is a cross-sectional view along the radial direction through the shaft of the plunger according to the second embodiment.This is a cross-sectional view along the longitudinal direction through which the plunger shaft passes.This is a drive spring according to one embodiment of the present disclosure.This is the drive spring shown in Figure 11A, which is incorporated into the drug delivery device and operates the plunger.These are the drive springs shown in Figures 11A and 11B, which are assembled within the drug delivery device, before the plunger is activated.This is a perspective view of the drive spring holder.This is a perspective view of the drive spring holder.This is a syringe return prevention mechanism.This is a cross-sectional view of the proximal portion of the drive spring holder.This is a different embodiment of the flexible portion of the drive spring holder.This is a different embodiment of the flexible portion of the drive spring holder.This is a different embodiment of the flexible portion of the drive spring holder.It is any audible indicator (clicker).An example is an indicator holder included on a drive spring holder.This is a perspective view of the support structure at the distal end of the flexible support arm.This is a perspective view of the guide structure of the indicator holder.This is a cross-section