JP-7854669-B2 - Dispensing apparatus, mixing apparatus, and analytical apparatus

Inventors

• 加藤 久典
• 齋藤 憲司
• 久慈 知明

Assignees

• 国立大学法人 東京大学
• Ｂｌｕｅ Ｉｎｄｕｓｔｒｉｅｓ株式会社

Dates

Publication Date

20260507

Application Date

20230712

Priority Date

20220727

Claims (6)

1. A dispensing device for dispensing liquid samples, It has a cylindrical body, an opening formed in the body, a lid that closes the opening and is more flexible than the body, and a cylindrical first channel for flowing a liquid first sample down, A pressing part for pressing the lid, The system includes a pressing control unit that controls the pressing of the pressing part onto the lid, The first channel is, A sample inlet is formed upstream of the aforementioned lid portion. A dispensing device characterized by having an injection port for injecting gas between the sample inlet and the lid.
2. The pressing portion has a plurality of blades that can rotate around a rotation axis, The dispensing apparatus according to claim 1, characterized in that the pressing control unit rotates the rotating shaft.
3. Multiple first channels are provided, The dispensing device according to claim 1, characterized in that one of the pressing parts is capable of pressing multiple of the lid parts simultaneously.
4. A mixing device comprising the dispensing device described in claim 1, and for mixing the first sample and the second sample, A second channel connected downstream of the cover portion of the first channel, A cylindrical third channel for the second sample to flow down, The confluence where the second channel and the third channel merge, A mixing channel for generating a mixed sample obtained by mixing the first sample and the second sample is provided downstream of the confluence section. At least one of the first sample and the second sample includes a magnetic insulator. The mixing device is characterized in that the mixing channel is equipped with an electromagnet.
5. The third channel is, A widening section that widens from the upstream side to the downstream side, The mixing apparatus according to claim 4, characterized in that it has a plurality of double-frustoconical sections, each formed by a pair of a narrowing section provided downstream of the widening section and narrowing from the upstream side to the downstream side.
6. An analytical apparatus comprising the mixing apparatus described in claim 4, and for analyzing the mixed sample, An irradiation unit that irradiates light onto the mixed sample attached to the electromagnet, A measuring unit for measuring the reflected light of the light irradiated by the aforementioned irradiation unit, An analytical apparatus characterized by comprising: a quantitative unit that quantifies the mixed sample based on the results measured by the measuring unit.

Description

This invention relates to a dispensing device, a mixing device, and an analytical device for dispensing liquid samples. Conventionally, a dispensing apparatus for dispensing samples has been disclosed in Patent Document 1. The dispensing device described in Patent Document 1 employs a configuration that includes a ceramic heater that heats a portion of the cleaning solution filling the flow path to generate bubbles, and a ceramic heater that heats the cleaning solution at a position closer to the syringe piston pump than the heating position of the ceramic heater to generate other bubbles with a layer of cleaning solution interposed between them. Japanese Patent Publication No. 2005-3610 Figure 1 is a schematic diagram showing an example of an analytical apparatus in the first embodiment.Figure 2 shows an example of a dispensing device in the first embodiment.Figure 3 illustrates an example of a dispensing method using the dispensing device in the first embodiment. Figure 3(a) shows the state before dispensing by the injection unit, and Figure 3(b) shows the state after dispensing by the injection unit.Figure 4 illustrates an example of a dispensing method using the dispensing device in the first embodiment. Figure 4(a) shows the state in which the lid is pressed by the pressing part, and Figure 4(b) shows the state after the lid has been pressed by the pressing part.Figure 5 illustrates an example of a dispensing method using the dispensing device in the first modified example. Figure 5(a) shows the state before the lid is pressed by the pressing part, and Figure 5(b) shows the state after the lid has been pressed by the pressing part.Figure 6 shows an example of a dispensing device in the second modified example.Figure 7 shows an example of a mixing apparatus in the first embodiment.Figure 8 illustrates a method for dispensing a liquid sample using a third channel. Figure 8(a) shows the sample before dispensing by the injection unit, and Figure 8(b) shows the sample after dispensing by the injection unit.Figure 9 shows an example of a method for mixing samples using a mixing device in the first embodiment.Figure 10 shows an example of a method for mixing samples using a mixing device in the first embodiment.Figure 11 shows an example of a method for mixing samples using a mixing device in the first embodiment.Figure 12 shows an example of a mixing apparatus in the first modified example.Figure 13 shows an example of a method for mixing samples using a mixing apparatus in the first modified example. Figure 13(a) shows the state before the sample is attached to the electromagnet, and Figure 13(b) shows the state after the sample has been attached to the electromagnet.Figure 14 shows an example of a method for mixing samples using a mixing apparatus in the first modified example. Figure 14(a) shows the state before mixing the samples, and Figure 14(b) shows the state after mixing the samples.Figure 15 shows an analytical apparatus in which an irradiation unit and a measurement unit are provided in a mixing device.Figure 16 shows an example of a method for measuring a mixed sample using the analytical apparatus in the first embodiment. Figure 16(a) shows the state before the sample is attached to the electromagnet, and Figure 16(b) shows the state after the sample has been attached to the electromagnet.Figure 17 shows an example of a method for measuring a mixed sample using the analytical apparatus in the first embodiment. Figure 17(a) shows the state before mixing the reagents, and Figure 17(b) shows the state after mixing the reagents.Figure 18 shows an example of a method for measuring a mixed sample using the analytical apparatus in the first embodiment. The following describes in detail, with reference to the drawings, embodiments for implementing the dispensing device, mixing device, and analytical device to which the present invention is applied. <First Embodiment: Analytical Apparatus 100> Figure 1 is a schematic diagram showing an example of the analytical apparatus 100 in the first embodiment. As shown in Figure 1, the analytical apparatus 100 comprises a dispensing device 1, a mixing device 2, an information processing device 4, an imaging device 51, an irradiation unit 52, and a measurement unit 53. The analytical apparatus 100 analyzes samples such as liquid specimens. <Dispensing device 1> Figure 2 shows an example of a dispensing device 1 in the first embodiment. As shown in Figure 2, the dispensing device 1 dispenses a liquid sample 7. The dispensing device 1 has a first flow path 11, a pressing unit 12, and a pressing control unit 13. The first channel 11 is through which the liquid sample 7 flows. A sample injection port 11a is formed on the upstream side of the first channel 11 in the direction of flow of the sample 7. A sample injection device (not shown) is provided at the sample injection port 11a, and the sample 7 can be injected into the first channel 11 by this device. The sample inj