JP-7855171-B2 - A device and program that measures changes in pupil diameter due to light stimulation and determines the subject's physical condition.

JP7855171B2JP 7855171 B2JP7855171 B2JP 7855171B2JP-7855171-B2

Inventors

倉島渡
菊池光一

Assignees

ＫＩＫＵＲＡ株式会社
株式会社ナックイメージテクノロジー

Dates

Publication Date: 20260508
Application Date: 20230703

Claims (4)

A display image control unit that changes the same or different display images displayed on the display unit in accordance with the left and right eyes of the subject , An eyeball imaging unit that simultaneously captures images of the left and right eyeballs of the subject who is visually viewing the displayed image using separate, independent cameras, After displaying a low-luminance screen to the left and right eyes of the subject until the pupil diameter stabilizes, a predetermined short-term high-luminance screen is displayed, and then the low-luminance screen is displayed. Using this display pattern of the displayed image, the change in pupil diameter over time of the left and right eyes of the subject, as captured by the eye imaging unit , is determined. From the change in pupil diameter over time, first data consisting of the pupil diameter contraction rate A, pupil diameter re-expansion rate B, pupil diameter contraction judgment ratio U, and pupil diameter re-expansion judgment ratio U2 of the subject is obtained, and second data consisting of the pupil diameter contraction judgment time E and pupil diameter re-expansion judgment time G of the subject is obtained. The system includes a determination unit that determines the brain disease state or autonomic nervous system dysfunction state of the subject based on the first data and the pupil diameter contraction rate A, pupil diameter re-expansion rate B, pupil diameter contraction determination ratio U, and pupil diameter re-expansion determination ratio U2 of a healthy person, or based on the second data and the pupil diameter contraction determination time E and pupil diameter re-expansion determination time G of the healthy person , The determination unit, When the high-brightness screen is displayed after the low-brightness screen, the pupil diameter position at time t2, which is determined to have started later than the time t1 of the high-brightness screen display, is defined as the pupil diameter contraction start determination point 403. When the low-luminance screen is displayed after the high-luminance screen, the pupil diameter position at time t4, when it is determined that the pupil diameter contraction has finished later than the time t3 when the low-luminance screen was displayed, is defined as the pupil diameter contraction completion determination point 404, and the pupil diameter position at time t6, when it is determined that the pupil diameter re-expansion has started, is defined as the pupil diameter re-expansion start determination point 405. The difference between the stable pupil diameter h when displaying the low-brightness screen and the stable pupil diameter r when displaying the high-brightness screen is defined as the maximum pupil diameter change K. The amount by which the pupil diameter changes from the pupil diameter contraction start determination point 403 to the pupil diameter contraction end determination point 404 is defined as the pupil diameter change contraction determination amount I. If the high-brightness screen is displayed using the above display pattern, followed by the low-brightness screen, and then the high-brightness screen is displayed again, and the difference between the pupil diameter n at the point t9 when the pupil diameter continues to expand and reaches its peak, and the pupil diameter r, is defined as the pupil diameter re-expansion amount N, Based on the pupil diameter contraction start determination point 403 and the pupil diameter contraction end determination point 404, the pupil diameter contraction speed A is determined. Based on the pupil diameter re-expansion start determination point 405 and the pupil diameter position 406 at a predetermined time after the pupil diameter re-expansion has started, the pupil diameter re-expansion speed B is determined. The ratio of the pupil diameter contraction determination amount I to the maximum pupil diameter change amount K is determined as the pupil diameter contraction determination ratio U. The ratio of the pupil diameter re-expansion amount N to the maximum pupil diameter change amount K is determined as the pupil diameter re-expansion determination ratio U2. The pupil diameter constriction determination time E is obtained by subtracting the time t1 of the display of the high-brightness screen from the time t2 of the pupil diameter constriction start determination point 403. The apparatus is characterized by determining the pupil diameter re-expansion determination time G by subtracting the time t4 of the pupil diameter contraction termination determination point 404 from the time t6 of the pupil diameter re-expansion start determination point 405 .
A display image control unit that changes the same or different display images displayed on the display unit in accordance with the left and right eyes of the subject , An eyeball imaging unit that simultaneously captures images of the left and right eyeballs of the subject who is visually viewing the displayed image using separate, independent cameras, After displaying a low-luminance screen to the left and right eyes of the subject until the pupil diameter stabilizes, a high-luminance screen is displayed until the pupil diameter stabilizes, and then the low-luminance screen is displayed for a predetermined short period of time. Using this display pattern of the displayed image, the change in pupil diameter over time of the left and right eyes of the subject, as captured by the eye imaging unit , is determined. From the change in pupil diameter over time, first data consisting of the pupil diameter contraction rate C, pupil diameter re-expansion rate D, and pupil diameter re-expansion judgment ratio Y of the subject is obtained, and second data consisting of the pupil diameter contraction judgment time V and pupil diameter re-expansion judgment time O of the subject is obtained. The system includes a determination unit that determines the brain disease state or autonomic nervous system dysfunction state of the subject based on the first data and the pupillary dilation rate C, pupillary re-dilation rate D, and pupillary re-dilation determination ratio Y of a healthy person, or based on the second data and the pupillary dilation determination time V and pupillary re-dilation determination time O of the healthy person , The determination unit, When the high-brightness screen is displayed, the pupil diameter position at time t11, when it is determined that the pupil diameter contraction started later than the time t10 of the display of the high-brightness screen, is defined as the pupil diameter contraction start determination point 603, and the pupil diameter position at time t12, when it is determined that the pupil diameter contraction has finished, is defined as the pupil diameter contraction end determination point 604 . The position of the pupil diameter at the time t14 when it is determined that the pupil diameter has started to re-expand after the high-brightness screen has been displayed is defined as the pupil diameter re-expanding start determination point 605. The difference between the stable pupil diameter h in the low-brightness display and the stable pupil diameter r in the high-brightness display is defined as the maximum pupil diameter change Q. If, after displaying the high-brightness screen using the aforementioned display pattern, the low-brightness screen is displayed, and then the high-brightness screen is displayed again, the difference between the pupil diameter o and the pupil diameter r at the point t17 when the pupil diameter continues to expand and reaches its peak after the low-brightness screen is displayed is defined as the pupil diameter re-expansion amount S. Based on the pupil diameter contraction start determination point 603 and the pupil diameter contraction end determination point 604, the pupil diameter contraction rate C is determined. Based on the pupil diameter re-expansion start determination point 605 and the pupil diameter position 606 at a predetermined time after the pupil diameter re-expansion has started, the pupil diameter re-expansion speed D is determined. The ratio of the pupil diameter re-expansion amount S to the maximum pupil diameter change amount Q is determined as the pupil diameter re-expansion determination ratio Y. The pupil diameter contraction determination time V is obtained by subtracting the time t10 of the display of the high-brightness screen from the time t11 of the pupil diameter contraction start determination point 603. The apparatus is characterized by determining the pupil diameter re-expansion determination time O by subtracting the time t13 when the low-luminance screen is displayed after the high-luminance screen is displayed from the time t14 of the pupil diameter re-expansion start determination point 605 .
In the apparatus according to claim 1 or 2 , The brain diseases in the aforementioned brain disease state are defined as epilepsy , neurodegenerative diseases , neural stem cell diseases , neural progenitor cell diseases , ischemic diseases , neurological trauma , emotional disorders , neuropsychiatric disorders , retinal degenerative diseases , retinal damage/trauma , cognitive/learning/memory impairments , Alzheimer's disease , mild cognitive impairment (MCI) , Parkinson's disease , Parkinson's syndrome , Huntington's disease , amyotrophic lateral sclerosis , ischemic stroke , traumatic brain injury , depression , bipolar depression/disorder , chronic fatigue syndrome , anxiety syndrome/disorder , autism , or Asperger's syndrome . A device characterized in that the autonomic nervous system dysfunction in the aforementioned state of autonomic nervous system dysfunction is defined as poor physical condition.
A program for causing a computer to function as the device described in claim 1 or 2.

Description

This invention relates to a device that uses the principle that brain activity and autonomic nervous system activity are reflected in changes in the eyeball (pupil) to stimulate a subject with light, analyze the movement of the subject's left and right eyeballs, and determine whether the subject has a brain disease or autonomic nervous system disorder. More specifically , this invention relates to a determination device that uses changes in the pupil diameter of the subject's left and right eyes when the subject is shown independent images to the left and right eyes to determine whether the subject is suffering from a brain disease or autonomic nervous system disorder. International publication WO2017-057631 describes a device for determining a subject's emotions . Using the device described in the above publication , it is possible to determine a subject's emotions by photographing their pupils , while eliminating the influence of factors such as the subject's respiration , ambient light and darkness , and pulse rate. There was a need for the development of a new device that could photograph the pupils of subjects , similar to the device described above, and a system for determining the subject's physical condition. International Open Brochure WO2017-057631PCT/JP2019/048894Japanese Patent Application No. 2022-83400 Image of a measuring instrumentExamples of changes in pupil diameter in subjects when exposed to high-intensity screens for short periods.Brightness change of the display screen for pupil diameter change in Figure 2.A model of pupil diameter changes in subjects when a high-brightness screen is displayed on the screen for a short period of time.Changes in display screen brightness due to pupil diameter change (Figure 4)A model of pupil diameter changes in subjects when a high-brightness screen is displayed on the screen for a short period of time.Changes in display screen brightness due to pupil diameter change (Figure 6)An example where the pupil diameters of the left and right pupils are different.An example where the movement of the left and right pupils is not synchronized. The embodiments for carrying out the present invention will be described below with reference to the drawings. The present invention is not limited to the embodiments described below , but also includes modifications made to the embodiments described below to the extent that is obvious to those skilled in the art. According to this invention , a device can be provided that can determine whether a subject has a brain disease , whether the brain disease is severe , whether the risk of developing a brain disease is high , or the degree of autonomic nervous system dysfunction, simply by using a relatively simple device (for example, a device that can simultaneously capture images of the left and right eyeballs with separate cameras and simultaneously display identical or different images for the left and right eyes). Examples of brain disorders include epilepsy , neurodegenerative diseases , neural stem cell diseases , neural progenitor cell diseases , ischemic diseases , neurotrauma , emotional disorders , neuropsychiatric disorders , retinal degenerative diseases , retinal damage/trauma , cognitive, learning, and memory impairments , Alzheimer 's disease , mild cognitive impairment (MCI) , Parkinson's disease , Parkinsonian syndromes , Huntington's disease , amyotrophic lateral sclerosis , ischemic stroke , traumatic brain injury , depression , bipolar depression/disorder , chronic fatigue syndrome , anxiety syndrome/disorder , autism , or Asperger's syndrome. Industrial applications of autonomic nervous system dysfunction assessment include determining the physical condition of individuals engaged in occupations where incorrect behavior is unacceptable from an occupational safety and health perspective, such as bus drivers, taxi drivers, large and long-haul truck drivers, train drivers, aircraft pilots, and other transportation operators, as well as construction site managers and workers, and factory machinery operators.