JP-7855174-B2 - Polymer composition

Inventors

• 田中 賢
• 小林 慎吾
• 西村 文男
• 枝連 未奈里
• 西浦 聖人

Assignees

• 国立大学法人九州大学
• 第一工業製薬株式会社

Dates

Publication Date

20260508

Application Date

20210331

Claims (4)

1. A polymer composition comprising a polymer having urethane bonds in the polymer main chain and a polyoxyethylene structure in the side chain portion relative to the polymer main chain, The polymer main chain includes structures derived from at least one of the polyisocyanates tetramethylene diisocyanate, dodecamethylene diisocyanate, hexamethylene diisocyanate (HMDI), 2,2,4-trimethylhexamethylene diisocyanate, 2,4,4-trimethylhexamethylene diisocyanate, lysine diisocyanate, 2-methylpentane-1,5-diisocyanate, and 3-methylpentane-1,5-diisocyanate , as well as structures derived from polycarbonate polyols . The mass proportion of the structure derived from the polycarbonate polyol is 90 parts by mass or more out of 100 parts by mass of the structure derived from polyols other than polyethylene glycol. A polymer composition characterized by being used for the purpose of forming a surface that suppresses nonspecific adsorption of proteins.
2. The polymer composition according to claim 1, characterized in that it is used for the purpose of forming a surface with a low frequency of platelet adhesion when used in contact with blood, by suppressing non-specific adsorption of proteins.
3. The polymer composition according to claim 1, characterized in that it is used for the purpose of forming an antifouling surface by reducing the frequency of bacterial adhesion through the suppression of nonspecific adsorption of proteins.
4. An aqueous dispersion characterized by dispersing fine particles containing the polymer composition described in any one of claims 1 to 3 in an aqueous phase.

Description

This invention relates to polymer compositions and the like used, for example, to create a surface that is less likely to be recognized as a foreign substance by biological tissues or blood when used in contact with them. Generally, when biological tissues or blood come into contact with the surface of a substance not derived from a living organism, the surface of the substance is recognized as a foreign object. This leads to non-specific adsorption and denaturation of proteins from the biological tissue to the surface, as well as activation of the coagulation system, complement system, platelet system, etc., resulting in the adsorption of blood cells such as platelets to the surface. In contrast, recent research has focused on the state of water molecules contained on the surface of synthetic polymers with a predetermined structure. It has become clear that by forming a surface capable of containing water molecules in a state referred to as "intermediate water," non-specific adsorption of proteins to the surface and denaturation of adsorbed proteins can be prevented. Furthermore, it has become clear that such surfaces exhibit a lower frequency of adhesion of platelets and other substances when in contact with blood, and that inflammation caused by contact with in vivo tissues can be suppressed (see, for example, Non-Patent Document 1). The presence of "intermediate water" as described above suppresses non-specific adsorption of proteins to the surface of a substance, resulting in the suppression of various problems that occur in biological tissues and blood that come into contact with it. This state is generally described as having biocompatibility (blood compatibility). Furthermore, in medical devices such as artificial lungs, dialysis machines, blood storage bags, platelet storage bags, blood circuits, artificial hearts, indwelling needles, catheters, guidewires, stents, artificial blood vessels, and endoscopes, it is desirable to achieve the above-mentioned biocompatibility (blood compatibility) in order to suppress the phenomena described above that occur when biological tissues or blood come into contact with the surface of the medical device (see, for example, Patent Document 1). As a method for imparting biocompatibility to the surface of medical devices that come into contact with biological tissues or blood, for example, as described in Patent Document 2, a common method involves using a material with suitable mechanical properties for constructing the medical device as a base material, and then applying a biocompatible substance as a coating to its surface by means of a coating or other means. Polyoxyethylene, obtained by ring-opening polymerization of ethylene oxide and represented by a structure with repeating units of ( C2H4 - O), is generally also called polyethylene glycol because it has hydroxyl groups at both ends of the polymerization chain. This polyethylene glycol (hereinafter sometimes referred to as "PEG") is known to exhibit excellent biocompatibility and low toxicity to living organisms, and is expected to be used as a medical material to impart biocompatibility by applying a PEG-containing coating to the surface of medical devices. However, since PEG itself is water-soluble, to prevent elution when used in contact with blood or other substances as a medical material, it is necessary to form a water-insoluble substance containing PEG by means of forming copolymers with other polymers, thereby conferring water resistance while maintaining the biocompatibility exhibited by PEG. On the other hand, because the mechanism by which PEG exhibits biocompatibility is not entirely clear, various methods are being explored to address this issue by incorporating the structure of PEG and achieving both biocompatibility and water resistance. For example, Patent Document 3 describes wound dressing sheets and intravascular embolization materials formed by dissolving a water-insoluble hydrophilic polymer containing PEG in an organic solvent. Patent Document 3 describes how to create a water-insoluble PEG-based polymer by forming a block copolymer of PEG and a biodegradable polymer. Patent Document 4 describes a technique for hydrophilizing a plastic surface that comes into contact with living tissue by grafting PEG onto it using gamma-ray irradiation. Furthermore, Patent Document 5 describes a technique for forming a surface with low protein adsorption by photopolymerizing a copolymer containing PEG on the surface of a substrate. Furthermore, Patent Document 6 describes a polymer composition that exhibits biocompatibility by introducing PEG constituent units as side chains to a (meth)acrylate main chain, and states that it can be used as a coating agent for imparting biocompatibility by dissolving it in a predetermined organic solvent according to its structure. Japanese Patent Publication No. 2018-17720Japanese Patent Publication No. 2020-110638Japanese Patent Publication No. 2004-339497Special Publ