JP-7855182-B2 - Mucosal model

Inventors

• 宮脇 まなみ
• 福田 祐子
• 菅野 武
• 荒田 悠太郎
• 正宗 淳

Assignees

• デンカ株式会社
• 国立大学法人東北大学

Dates

Publication Date

20260508

Application Date

20240730

Claims (13)

1. A mucosal model having a first layer and a second layer laminated on the first layer, A simulated mucosal layer having the first layer and the second layer, The simulated mucosal layer comprises a simulated submucosal layer provided below the second layer of the simulated mucosal layer, The thickness of the first layer is 0.01 to 3 mm. The second layer has a volume resistivity of 1.0 × 10¹ to 1.0 × 10⁷ Ω·cm across its entire surface or in part. A mucosal model in which the color difference ΔE between the first layer and the second layer is 20 or more.
2. A mucosal model having a first layer and a second layer laminated on the first layer, The thickness of the first layer is 0.01 to 3 mm. The second layer has a volume resistivity of 1.0 × 10¹ to 1.0 × 10⁷ Ω·cm across its entire surface or in part. The color difference ΔE between the first layer and the second layer is 20 or more. A mucosal model in which the melting point of the first layer is below the melting point of the second layer.
3. The mucosal model according to claim 1 or 2, wherein the thickness of the second layer is 0.1 mm to 50 mm.
4. The mucosal model according to claim 1 or 2, wherein the melting point of the first layer is 50 to 220°C.
5. The mucosal model according to claim 1 or 2, wherein the melting point of the second layer is 50 to 240°C.
6. The mucosal model according to claim 1 or 2, wherein the first layer comprises one or more selected from the group consisting of thermoplastic resins, proteins, and polysaccharides.
7. The mucosal model according to claim 1 or 2, wherein the second layer comprises one or more selected from the group consisting of thermoplastic resins, proteins, and polysaccharides.
8. The mucous membrane model according to claim 1 or 2, wherein a lubricating composition is applied to the surface of the first layer.
9. A mucosal model according to claim 1 or 2, for use in endoscopic procedure training.
10. An organ model comprising the mucosal model described in claim 1 .
11. An endoscopic procedure training method comprising performing endoscopic procedure training using the mucosal model described in claim 1 or 2, or the organ model described in claim 10.
12. The endoscopic procedure training method according to claim 11, wherein the mucosal model has a simulated lesion on a portion of the surface of the first layer, and the method includes marking the first layer around the simulated lesion with an energy device to set the resection range.
13. The endoscopic procedure training method according to claim 11, wherein the mucosal model comprises a simulated mucosal layer having the first and second layers, and a simulated submucosal layer provided below the second layer of the simulated mucosal layer.

Description

This disclosure relates to a mucosal model. In recent years, there has been growing expectation for minimally invasive surgery, such as endoscopy and laparoscopy, which places less burden on the body and offers the potential for early recovery. The number of such surgeries is increasing. For example, removing tumors in the mucosal layer of organs endoscopically (endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD)) allows for surgery through smaller incisions compared to conventional open surgery. Furthermore, endoscopic hemostasis of gastrointestinal bleeding prevents shock due to bleeding, avoiding emergency surgery. This reduces the physical burden on patients, allowing for shorter hospital stays and earlier return to normal life. Therefore, there is a growing demand for surgical training models for doctors and medical students that are compatible with endoscopic and laparoscopic surgery. To date, several medical training models have been proposed to improve skills and the quality of medical procedures (Patent Documents 1-5). Japanese Patent Publication No. 2006-116206Japanese Patent Publication No. 2008-197483Japanese Patent Publication No. 2018-17769Japanese Patent Publication No. 2017-107094Japanese Patent Publication No. 2016-38563 This is a schematic cross-sectional view of a mucosal model according to the first embodiment of this disclosure.This is a schematic cross-sectional view of the simulated mucosal layer in a mucosal model according to the first embodiment of the present disclosure, in which the simulated mucosal layer surrounding a simulated lesion set on a first layer is marked with an energy device.This is a plan view of the mucosal model according to the first embodiment of the present disclosure, in which the simulated mucosal layer surrounding the simulated lesion, which is set on the first layer, is marked with an energy device.This is a schematic cross-sectional view of a mucosal model according to a second embodiment of the present disclosure, and is a cross-sectional view of a mucosal model according to a first embodiment in which a simulated submucosal layer is provided below the second layer of the simulated mucosal layer.This is a perspective view of a mucosal model according to a second embodiment of the present disclosure, in which the simulated mucosal layer surrounding the simulated lesion, which is set on the first layer, is marked with an energy device. The following describes in detail one embodiment of this disclosure, but the scope of this disclosure is not limited to the embodiment described herein, and various modifications can be made without departing from the spirit of this disclosure. Each embodiment disclosed herein can be combined with any other features disclosed herein. Furthermore, if multiple upper and lower limits are described for a particular parameter, any combination of these upper and lower limits can be used to create a suitable numerical range. Also, the lower and/or upper limits of the numerical ranges described herein may be replaced with numerical values within that range, as shown in the examples. The expression "X to Y" indicating a numerical range means "X or greater and Y or less." If a particular description given for one embodiment also applies to other embodiments, that description may be omitted in the other embodiments. [First Embodiment] The mucosal model according to the first embodiment is a mucosal model having a first layer and a second layer laminated on the first layer, wherein the thickness of the first layer is 0.01 to 3 mm, the second layer has a volume resistivity of 1.0 × 10¹ to 1.0 × 10⁷ Ω·cm for the entire surface or a part thereof, and the color difference ΔE between the first layer and the second layer is 20 or more. According to the mucosal model according to this embodiment, it is easy to distinguish each layer of mucosal tissue exposed during procedures such as excision and dissection, and visibility is excellent. Furthermore, excision and dissection using energy devices such as general electrosurgical units are easy.Therefore, for example, training can be performed on excision and/or dissection of mucosal tissue using energy devices, and on marking of the excision site performed prior to such training, and it is easy to determine whether the intended procedure has been performed. In this specification, the term "mucosa" in a mucosal model is not limited to any tissue capable of secreting mucus in an animal's body, but rather refers to at least a portion of the mucosa of organs such as the digestive, urinary, reproductive, and respiratory organs. Examples of digestive organs include the oral cavity, pharynx, esophagus, stomach, duodenum, small intestine, large intestine, rectum, and anus; examples of urinary organs include the ureters, bladder, and urethra; examples of reproductive organs include the fallopian tubes, uterus, vagina, vas deferens, penis, and urethra; and examples of respiratory or