JP-7855211-B2 - Topical skin preparations

Inventors

• 辻 礼奈
• 澤木 茂豊

Assignees

• 共栄化学工業株式会社

Dates

Publication Date

20260508

Application Date

20210116

Priority Date

20200911

Claims (3)

1. A collagen synthesis promoter in a topical skin preparation containing water of green rooibos, a mixed solvent of water and a polyhydric alcohol, or a mixed solvent of water and a lower alcohol .
2. A neutrophil-like cell migration activity inhibitor in a topical skin preparation containing water from green rooibos, a mixed solvent of water and a polyhydric alcohol, or a mixed solvent of water and a lower alcohol .
3. A topical skin preparation for promoting collagen synthesis or inhibiting neutrophil-like cell migration activity, comprising the agent described in claim 1 or 2.

Description

This invention relates to a topical skin preparation containing a plant-derived component as an active ingredient. In recent years, from the perspective of biosafety, the development of various plant-derived ingredients for topical skin preparations has been progressing. However, plant-derived ingredients have had problems in terms of efficacy and stability. In particular, there have been issues such as the possibility that plant-derived ingredients may not exhibit sufficient efficacy. Preferred embodiments of the present invention will be described in detail below. First, the extracting material, rooibos (Aspalathus linearis), is a plant belonging to the genus Aspalathus in the legume family. In this invention, unfermented, green rooibos (green rooibos) is used. The whole plant or leaves are preferred as the part to be used. The green rooibos used as the extraction material can be fresh, pre-dried, or semi-dried. Furthermore, it can be used in its raw, harvested form or as dried and ground rooibos. The extraction is prepared by washing the extraction material as needed to remove impurities, then either leaving it as is or drying it, and then finely chopping or grinding it as needed, before contacting it with the extraction solvent for extraction. Extraction can be carried out by conventional methods such as immersion, but supercritical fluid extraction can also be used. Examples of extraction solvents include water; lower alcohols such as methanol, ethanol, and propanol; polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butylene glycol, and glycerin; esters such as ethyl acetate, butyl acetate, and methyl propionate; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; and hydrocarbon solvents such as n-hexane, toluene, and chloroform. These can be used individually or in combination of two or more. Among these extraction solvents, hydrophilic solvents such as water, lower alcohols, or polyhydric alcohols are preferred in this invention, from the viewpoint of skin irritation, effectiveness, and broad applicability to cosmetics. Preferred examples of using these hydrophilic solvents include, for example, the use of water, lower alcohols (especially ethanol), or polyhydric alcohols (especially 1,3-butylene glycol) alone, or a mixed solvent of water and lower alcohols (especially ethanol), or a mixed solvent of water and polyhydric alcohols (especially 1,3-butylene glycol, glycerin). Among these, water alone or a mixed solvent of water and 1,3-butylene glycol are particularly preferred. When using a mixed solvent, the preferred mixing ratio is, for example, 1:10 to 20:1 by volume (the same applies hereinafter) for a mixed solvent of water and 1,3-butylene glycol, 1:10 to 25:1 for a mixed solvent of water and ethanol, and 1:10 to 20:1 for a mixed solvent of water and glycerin. While there are no particular limitations on the pH of the extract during preparation, it is generally preferable to have a pH in the range of 3 to 9. In this sense, if necessary, the extraction solvent may be adjusted to the desired pH by adding an alkaline adjusting agent such as sodium hydroxide, sodium carbonate, or potassium hydroxide, or an acidic adjusting agent such as citric acid, hydrochloric acid, phosphoric acid, or sulfuric acid. Extraction conditions, such as extraction temperature and time, vary depending on the type of solvent and pH used. For example, when using water, 1,3-butylene glycol, or a mixture of water and 1,3-butylene glycol as the solvent, the extraction temperature is preferably in the range of 0°C to 90°C. The extraction time is preferably in the range of 1 to 168 hours (1 hour to 1 week). The extract prepared as described above may generally be used as a topical skin preparation after adjusting the pH to 3-8, or it may be concentrated to a desired concentration by vacuum concentration, etc. Furthermore, the extract may be dried using conventional methods such as spray drying. Examples of topical skin preparations (topical medicinal components, quasi-drugs, and cosmetics) containing the extract of the present invention include, but are not limited to, emulsions, creams, lotions, essences, gels, packs, sheet masks, lipsticks, foundations, liquid foundations, makeup press powders, blushes, face powders, facial cleansers, body shampoos, slimming agents, hair shampoos, and soaps. Hair growth and hair nourishing agents, as well as bath additives, are also examples. The amount of the active ingredient according to the present invention in topical skin preparations (topical medicinal components, topical quasi-drugs, and cosmetics) is generally 0.0002 to 1.0% by weight (solids by weight, the same applies hereinafter) as the solid content in the case of basic cosmetics, preferably in the range of 0.002 to 0.2% by weight; generally in the range of 0.0002 to 1.0% by weight, preferably in the range of 0.002 to 0.2% by weight in the case of makeup cosmetics; an