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JP-7855650-B2 - Consumables data integration management system and platform

JP7855650B2JP 7855650 B2JP7855650 B2JP 7855650B2JP-7855650-B2

Inventors

  • コチャー、マニシュ
  • ニュエン、キム‐シュアン
  • オベロイ、パンカジュ
  • パン、ルイス ダブリュー．
  • パーカー、ジェニファー
  • ペリシア、ビクター
  • サモンズ、ニック
  • シガル、ジョージ
  • ウォルスタドター、ジェイコブ
  • ヴォック、マイク
  • スミス、スタンレー ティー．
  • ボスコ、ピーター ジェイ．
  • スティーブンス、カール シー．
  • オズボーン、ロジャー ディー．
  • ページ、ケネス
  • ウェイド、マイケル ティー．
  • ウィロービー、ジョン
  • ワン、レイ
  • チェンバリン、イアン ディー．
  • ジェフリ－コーカ、バンデル
  • ジョーンズ、エリック エム．
  • クリボイ、ゲーリー アイ．
  • クルーガー、ドン イー．
  • レイムクエラー、アーロン エイチ．
  • ウ、ペイ‐ミン

Assignees

  • メソ スケール テクノロジーズ エルエルシー

Dates

Publication Date
20260508
Application Date
20240815
Priority Date
20160722

Claims (10)

  1. An automated assay system, (a) A processing deck for holding assay components, having a surface with a front end , a first side end, a second side end, and a rear end edge, (i) an assay consumable storage unit , which is cantilevered and positioned near the center of the front end of the processing deck, having multiple consumable slots made to hold assay consumables, (ii) A plurality of pipette tip locations for holding pipette tip containers located on the first side of the processing deck, (iii) A plurality of plate shaker locations located along the rear edge of the processing deck, (iv) A set of processing locations located approximately in the center of the processing deck between the assay consumable storage unit and the plate shaker location, and configured to hold the assay consumables, (v) A barcode scanner located at the first side end of the processing deck behind the plurality of pipette tip locations, the processing deck having the barcode scanner having a scanning surface large enough to scan the bottom surface of the assay consumables, (b) A plate washer located below the processing deck and accessible through the opening in the processing deck between the plurality of pipette tip locations and the processing locations, (c) A gantry located above the processing deck that provides movable support for a robotic plate gripper, allowing the robotic plate gripper to access (i) to (v), and provides movable support for a robotic 8-channel pipette, allowing the robotic 8-channel pipette to access (ii) and (iv), (d) An assay reader located at the first side end of the processing deck and installed on a platform having a lower vertical height than the processing deck, An automated assay system comprising: (e) an enclosure surrounding (a) to (d) having a temperature controller for temperature control and a door that allows user access to the front end of the processing deck and the assay consumable storage unit.
  2. The automated assay system according to claim 1, wherein the assay consumable storage unit is configured as a shelf assembly and adapted to be mounted on the processing deck , and the plurality of consumable slots are configured as a plurality of sets of vertically aligned storage units.
  3. The automated assay system according to claim 2, wherein the assay consumable is a multiwell plate, and each of the vertically aligned storage units is made to be of a size and dimensions that can receive the multiwell plate.
  4. The automated assay system according to claim 3, wherein the shelf assembly comprises a plurality of horizontal members and a plurality of upright vertical supports.
  5. The automated assay system according to claim 4, wherein the assay consumable storage unit is fixed to the processing deck, and the shelf assembly is detachably attached to the processing deck by at least one screw-type connector having at least two positioning pins and a finger-operable head.
  6. The automated assay system according to claim 5, wherein the shelf assembly comprises a set of storage units arranged vertically in a linear arrangement of M x N, where M and N are integers.
  7. The automated assay system according to claim 5, wherein the upper horizontal member has a function for aligning the bottom of the container .
  8. The automated assay system according to claim 7, wherein the upper horizontal member is larger than the bottom of the container and has a function for aligning the lid of the assay reagent holder.
  9. The automated assay system according to claim 1, wherein the assay reader and the plate washer are positioned to provide clearance for the operation of the robotic plate gripper and the robotic 8-channel pipette.
  10. An automated assay system, (a) A processing deck for holding assay components, having a surface with a front end, a first side end, a second side end, and a rear end edge, (i) an assay consumable storage unit cantilevered over the front end of the processing deck, (ii) A plurality of pipette tip locations for holding pipette tip containers located on the first side of the processing deck, (iii) A plurality of plate shaker locations located along the rear edge of the processing deck, (iv) A set of processing areas located approximately in the center of the processing deck between the assay consumable storage unit and the plate shaker area, (v) The processing deck having a barcode scanner located at the first side end of the processing deck behind the plurality of pipette tip locations, (b) A plate washer located below the processing deck and accessible through the opening in the processing deck between the plurality of pipette tip locations and the processing locations, (c) A gantry located above the processing deck that movably supports the robot plate gripper and movably supports the robot 8-channel pipette, (d) An assay reader located at the first side end of the processing deck and installed on a platform having a vertical height lower than that of the processing deck, (e) An automated assay system comprising an enclosure surrounding (a) to (d), with a temperature controller for temperature control.

Description

Cross-referencing of related applications This international patent application is an "Integrated Consumable Data" application filed on July 22, 2016, with application number PCT/US2016/043755. We claim priority from an international patent application titled "Management System and Platform". See also U.S. concurrent application No. 12/844,345, filed July 27, 2010; U.S. provisional patent application No. 61/400,411, filed July 27, 2010; and U.S. provisional patent application No. 61/462,024, filed January 27, 2011. Furthermore, reference is also made to U.S. provisional patent applications entitled "Integrated Consumer Data Management System and Platform," filed on July 26, 2011, now U.S. Patent No. 8,770,471; U.S. provisional patent applications No. 14,719,818, filed on May 22, 2015; and U.S. provisional patent applications entitled "Integrated Consumer Data Management System and Platform," filed on July 23, 2015, with application number 62,195,956. The overall contents of each of these applications are incorporated herein by reference. Technical Field This instruction relates to methods, devices, and systems for associating consumable data with assay consumables used in biological assays. This instruction also relates to consumables (e.g., kits and reagent containers), software, data-expandable bundles, computer-readable media, loading carts, instruments, systems, and methods for performing automated biological assays. Numerous methods and systems have been developed for conducting assays. These methods and systems are essential in a wide range of applications, including medical diagnostics, veterinary testing, food and beverage testing, environmental monitoring, manufacturing quality control, drug discovery, and basic scientific research. During the manufacture and use of reagents and other consumables used in biological assays, reagents and consumables are typically coded and labeled by the manufacturer for tracking purposes. Furthermore, understanding the analytical results of any given assay requires tracking countless analytical parameters, often necessitating input from diverse parallel tracking systems supplied by the manufacturer, customer, or both. This diagram shows the generation and storage of consumables data, as well as consumables data provided by consumables manufacturers.This diagram shows the distribution of consumables data to customers who inquire about it.This figure shows the use of consumable data to verify the permitted use of consumables in the assay system.This diagram shows the interface between the master repository on the CD server, its contents, and/or additional vendor directories.This figure shows the assay reading device described herein.This figure shows the assay reading device described herein.This figure shows the assay reading device described herein.This figure shows the assay reading device described herein.This is an alternative diagram of the assay reader described herein.This is an alternative diagram of the assay reader described herein.This is an alternative diagram of the assay reader described herein.This is an additional diagram of the assay reader described herein.This figure shows the assay system described herein.This figure shows an assay system and the various subsystems included in that system. In particular, the system includes multiple subsystems positioned on a table or platform, and each subsystem is operablely connected to a robotic subsystem configured to access one or more consumables, such as multiwell assay plates, and to move from one subsystem to another within the assay system.This figure shows an assay system and the various subsystems included in that system.This figure shows an assay system and the various subsystems included in that system.This shows the scheduling of operations performed on the system during the assay.This figure shows one embodiment of an assay system and various subsystems within the system. The assay system shown in Figures 10(a) to 10(b) is configured to perform all sample preparation steps, as well as all assay processing steps required for performing the assay, onboard. The assay system is connected to a user interface configured to display step-by-step instructions to the user for appropriate sample/reagent preparation steps that need to be performed manually before the system performs the assay.This figure shows one embodiment of an assay system and various subsystems within the system.This figure shows another replication of the assay system shown in Figures 10(a) to 10(d).This diagram shows the top surface of the table supporting the assay system equipment.This is a perspective view of the training plate.This is a perspective view of the training plate.This is a perspective view showing the tip of a pipette entering the lid of a reagent trough.Figure 10(g) is a top view of the various cut patterns of the lid.This is a perspective view of the lid and assay plate.This is a cross-sectional view of the lid and as