JP-7855815-B2 - apple extract-containing composition

Inventors

• 遠藤 幸子

Assignees

• 株式会社ファンケル

Dates

Publication Date

20260511

Application Date

20211221

Claims (3)

1. A compression-molded formulation comprising an apple extract-containing composition comprising (A) apple extract in an amount of 3% to 35% by weight and (B) red yeast rice in an amount of 3% to 45% by weight, wherein the weight ratio of (A) to (B) (A/B) is 0.1 to 3.5.
2. (A) The compression-molded formulation according to claim 1, wherein the apple extract contains procyanidin.
3. (B) The compression molded formulation according to claim 1 or 2, wherein the red yeast rice contains red yeast rice polyketide.

Description

This invention relates to an apple extract-containing composition. Apples are a highly nutritious fruit, and the proverb "An apple a day keeps the doctor away" is used in English-speaking countries. Apples are rich in polyphenols, and for example, Patent Document 1 proposes a cholesterol metabolism regulator containing apple extract as an active ingredient, and Patent Document 2 proposes a proteasome activator containing apple extract as an active ingredient. Red yeast rice is a type of koji (fermented rice) produced by cultivating Monascus mold (a species of red yeast) on rice or other grains. It has a long history of consumption in East Asia, and is used in China and Taiwan for red wine, aged wine, and red tofu, and in Okinawa for tofu. It has been reported that monacolin K, a red yeast rice polyketide, suppresses cholesterol biosynthesis in the liver by antagonistically inhibiting HMG-CoA reductase (Non-Patent Literature 1). By inhibiting HMG-CoA reductase in the liver, monacolin K reduces cholesterol biosynthesis, and by increasing the expression of LDL receptors in the liver, it promotes the uptake of LDL cholesterol into the liver, ultimately lowering blood cholesterol levels. Japanese Patent Publication No. 2006-089457Japanese Patent Publication No. 2012-031133 Endo A. Monacolin K, a new hypocholesterolemic agent produced by a Monascus species. J Antibiot (Tokyo) 1979;32(8); 852-854. The present invention This invention relates to an apple extract-containing composition comprising (A) apple extract in an amount of 3% to 35% by weight and (B) red yeast rice, wherein the weight ratio of (A) to (B) (A/B) is 0.1 to 3.5. (A) Apple extract The apple (Malus pumila) variety used in the present invention is not particularly limited, and examples include Fuji, Kokko, Ohrin, Kogyoku, Jonagold, Delicious, Sansa, and Senshu. The part of the apple used for extraction is not particularly limited; for example, it could be the fruit, leaves, trunk, or flowers, but the fruit is preferred. The fruit can be unripe or ripe, but young fruit with a high polyphenol content is preferred. The part of the fruit used for extraction is not particularly limited; for example, it could be the whole fruit, pulp, peel, or seeds. Apple extract can be obtained by extracting these parts individually or in combination of two or more. Apples, especially young apples, are rich in polyphenols. The apple extract used in this invention is It is preferable that the material contains procyanidin, a type of polyphenol. Procyanidins are compounds formed by condensation or polymerization using flavan-3-ol derivatives as structural units. Examples of flavan-3-ol derivatives include catechin, epicatechin, gallocatechin, epigallocatechin, afzeletin, and epiafzeletin. The extraction solvent for obtaining apple extract is not particularly limited, but in order to obtain an extract rich in procyanidins, it is preferable to use alcohols such as methanol, ethanol, and propanol; ketones such as acetone and methyl ethyl ketone; nitriles such as acetonitrile; ethers such as tetrahydrofuran and diethyl ether; halogenated hydrocarbons such as dichloromethane and chloroform; esters such as ethyl acetate and ethyl formate; hexane; water, etc. The extraction method is not particularly limited, but methods using two-phase solvent partitioning or high-performance partition chromatography are preferred. The extraction temperature is usually in the range of 0 to 100°C, and preferably 5 to 50°C. The amount of extraction solvent is 1 to 100 w/w times the amount of the extract, preferably 5 to 10 w/w times. In addition, proteolytic enzymes may be added during extraction to perform hydrolysis. The extract can be purified by known methods. For example, after removing insoluble matter by filtration, centrifugation, decantation, etc., it can be fractionated, purified, and concentrated as needed using adsorbents such as activated carbon, activated clay, silica gel, or activated alumina synthetic resin for decolorization and deodorization purposes, or by solvent fractionation, reverse osmosis membrane, ion exchange, etc. However, since apple extract contains various useful components other than procyanidins, such as polyphenols, organic acids, and amino acids, it is preferable not to perform purification. The obtained extract can be used as is, or after being powdered by methods such as vacuum concentration, spray drying, or freeze-drying. The apple extract-containing composition of the present invention contains (A) apple extract in an amount of 3% to 35% by dry weight of the total composition. The apple extract content (dry weight) is preferably 5% or more, and preferably 30% or less. (B) Red yeast rice Red yeast rice can be used in the form of a powder obtained by drying and grinding the cells of Monascus red yeast, a red yeast rice extract, or a dried red yeast rice extract. The red yeast rice used in this invention preferably contains red yeast rice polyketides. Red yeas