JP-7855838-B2 - Growth inhibitor for fungi of the genus Malassezia

Inventors

• 鈴木 一裕
• 井上 瑞菜
• 高山 幸大

Assignees

• 大正製薬株式会社

Dates

Publication Date

20260511

Application Date

20210803

Priority Date

20200819

Claims (3)

1. A growth inhibitor for fungi of the genus Malassezia, characterized by containing hibiscus flower extract extracted using an aqueous ethanol solution as a solvent as an active ingredient.
2. A growth inhibitor for Malassezia fungi according to claim 1, for use on skin and/or hair.
3. The growth inhibitor according to claim 1 or 2, wherein the fungus of the genus Malassezia is Malassezia globesa.

Description

This invention relates to a growth inhibitor for fungi of the genus Malassezia. Malassezia fungi are yeast-like fungi that are normally present on human skin and are so-called lipophilic fungi that require lipids for their growth. Depending on the host's condition, they are known to be causative or exacerbating agents of skin diseases such as tinea versicolor, seborrheic dermatitis, Malassezia folliculitis, atopic dermatitis, psoriasis, and acne. Currently, Malassezia fungi are classified into 18 species, and Malassezia globesa and Malassezia restricular are species that are always detected in the skin of patients with skin diseases or in healthy individuals (Non-patent documents 1 and 2). Among the diseases mentioned above, for example, topical steroids, non-steroidal anti-inflammatory drugs, and antifungal agents such as ketoconazole are known as treatments for seborrheic dermatitis (Non-Patent Literature 3). Personia Vol. 41, 56-70, 2018Med. Mycol. J. Vol. 54(No.1), 39-44, 2013Jpn. J. Med. Mycol. Vol. 46 (No. 3), 163-167, 2005 The present invention provides a growth inhibitor for Malassezia fungi, containing at least one substance selected from the group consisting of hibiscus flower extract, ivy leaf/stem extract, royal jelly extract, Tencha extract, Scutellaria baicalensis extract, and N-[2-hydroxy-3-(trimethylammonio)propyl]hydrolyzed keratin chloride solution, and is used for skin and/or hair. Each of the above-mentioned agents can be appropriately used if they are of a quality typically used in pharmaceuticals, quasi-drugs, or cosmetics. The hibiscus flower extract of this invention is an extract obtained from the flowers of rosellus (scientific name: Hibiscus sabdariffa), a plant belonging to the Malvaceae family. The extraction method is not particularly limited and can be carried out according to conventional methods. Both polar and non-polar solvents can be used as the extraction solvent; for example, water, ethanol, propylene glycol, 1,3-butylene glycol, and mixtures thereof can be used. The extract may be used as is, or, if necessary, after treatment such as concentration, dilution, filtration, decolorization with activated carbon, deodorization, or ethanol precipitation. Furthermore, the extracted solution may be treated by concentration to dryness, spray drying, freeze-drying, etc., and used as a dried product. Commercially available products can also be used. The amount of hibiscus flower extract in the growth inhibitor for Malassezia fungi of the present invention is preferably 0.0001% to 20% by mass, and more preferably 0.001% to 10% by mass, relative to the total composition, when provided as a pharmaceutical, quasi-drug, cosmetic, or reagent. The Hedera helix leaf/stem extract of this invention is an extract obtained from the leaves and stems of Hedera helix, a plant belonging to the Araliaceae family. The extraction method is not particularly limited and can be carried out according to conventional methods. Both polar and non-polar solvents can be used as the extraction solvent; for example, water, ethanol, propylene glycol, 1,3-butylene glycol, and mixtures thereof can be used. The extract may be used as is, or, if necessary, after treatment such as concentration, dilution, filtration, decolorization with activated carbon, deodorization, or ethanol precipitation. Furthermore, the extracted solution may be treated by concentration to dryness, spray drying, or freeze-drying to obtain a dried product for use. Commercially available products can also be used. In the present invention's growth inhibitor for Malassezia fungi, the amount of Hedera helix (Ivy) leaf/stem extract is preferably 0.0001% to 20% by mass, and more preferably 0.001% to 10% by mass, relative to the total composition, when provided as a pharmaceutical, quasi-drug, cosmetic, or reagent. The royal jelly extract of the present invention is an extract obtained by extracting secretions secreted from the pharyngeal or mandibular glands of European honeybees (Apis mellifera L.) or Eastern honeybees (Apis indika Radoszkowski) from pollen and nectar produced in vivo. The extraction method is not particularly limited and can be carried out according to conventional methods. Both polar and non-polar solvents can be used as the extraction solvent; for example, water, ethanol, propylene glycol, 1,3-butylene glycol, and mixtures thereof can be used. The extract may be used as is, or, if necessary, after treatment such as concentration, dilution, filtration, decolorization with activated carbon, deodorization, or ethanol precipitation. Furthermore, the extracted solution may be treated by concentration to dryness, spray drying, or freeze-drying to obtain a dried product for use. Commercially available products can also be used. The amount of royal jelly extract in the growth inhibitor for Malassezia fungi of the present invention is preferably 0.0001% to 20% by mass, and more preferably 0.001% to 10% by mass, relative to the total co