JP-7856102-B2 - Method and system for calibrating cerebral hemodynamics

JP7856102B2JP 7856102 B2JP7856102 B2JP 7856102B2JP-7856102-B2

Inventors

フエイベルスウィレム
ファンドーレンマリーケ
ファンエーレイモンド
ラメリスルドルフマティアスヨハネスニコラース
ルーフケンスティミーロベルトスマリア
マッテルスマルコ
ウェステリンクヨアネヘンリエッテデジレモニーク
デニッセンアドリアヌスヨハネスマリア

Assignees

コーニンクレッカフィリップスエヌヴェ

Dates

Publication Date: 20260511
Application Date: 20211214
Priority Date: 20201215

Claims (12)

A system for creating hemodynamic brain atlases for the calibration of cerebral hemodynamics, A non-invasive transcranial nerve stimulator configured to induce neural activity in a target region of interest of the brain of a human subject to induce a hemodynamic response, the non-invasive transcranial nerve stimulator having transcranial functional ultrasound stimulation, A non-invasive neuromonitoring device configured to monitor evoked hemodynamic responses in the aforementioned target region of interest, A computing device configured to determine a set of parameters representing the hemodynamic response function of the induced hemodynamic response in the target region of interest, and to associate the set of parameters of the hemodynamic response function with the target region of interest to form the hemodynamic brain atlas. It has, The non-invasive transcranial nerve stimulator is configured to induce multiple hemodynamic responses in multiple target regions of interest, and each hemodynamic response is induced in each target region of interest. The computing device is configured to determine, for each induced hemodynamic response, a set of parameters representing the hemodynamic response function of the induced hemodynamic response, and to associate each of the sets of parameters with the target region of interest in which the induced hemodynamic response was induced, thereby forming a hemodynamic brain atlas usable for calibration of brain hemodynamics. The system further includes a sensory stimulation device configured to apply at least one sensory stimulus to a human subject in order to induce neural activity in order to elicit a hemodynamic response in the target region of interest. The computing device is configured to perform a comparison between the hemodynamic response induced by the non-invasive transcranial nerve stimulator and the hemodynamic response induced by the sensory stimulator, and to correct for potential neuron-induced confounding on the hemodynamic response function . system .
A system for creating hemodynamic brain atlases for the calibration of cerebral hemodynamics, A non-invasive transcranial nerve stimulator configured to induce neural activity in a target region of interest of the brain of a human subject to induce a hemodynamic response, the non-invasive transcranial nerve stimulator having transcranial functional ultrasound stimulation, A non-invasive neuromonitoring device configured to monitor evoked hemodynamic responses in the aforementioned target region of interest, A computing device configured to determine a set of parameters representing the hemodynamic response function of the induced hemodynamic response in the target region of interest, and to associate the set of parameters of the hemodynamic response function with the target region of interest to form the hemodynamic brain atlas. It has, The non-invasive transcranial nerve stimulator is configured to induce multiple hemodynamic responses in multiple target regions of interest, and each hemodynamic response is induced in each target region of interest. The computing device is configured to determine, for each induced hemodynamic response, a set of parameters representing the hemodynamic response function of the induced hemodynamic response, and to associate each of the sets of parameters with the target region of interest in which the induced hemodynamic response was induced, thereby forming a hemodynamic brain atlas usable for calibration of brain hemodynamics. The non-invasive transcranial nerve stimulator is configured to induce a sequence of hemodynamic responses in the target region of interest. The non-invasive neuromonitoring device is configured to monitor the sequence of evoked hemodynamic responses in the target region of interest. The computing device is configured to perform comparisons between sequences of evoked hemodynamic responses in order to correct for potential neuron-induced confounding on the hemodynamic response function . system .
The non-invasive neuromonitoring device is configured to monitor further evoked hemodynamic responses in one or more brain regions having sufficiently strong excitatory connectivity to the target region of interest. The computing device is configured to determine a set of parameters representing the hemodynamic response function of further induced hemodynamic responses in one or more brain regions, and to associate the set of parameters with the one or more brain regions to form the hemodynamic brain atlas. The system according to claim 1 or 2 .
The aforementioned target region of interest is selected from a set of calibration brain regions. The hemodynamic response function in other brain regions of the aforementioned brain can be derived from the hemodynamic response function in the set of calibrated brain regions. The system according to any one of claims 1 to 3 .
The aforementioned non-invasive transcranial nerve stimulator is The system according to any one of claims 1 to 4 , further comprising one or more of transcranial electrical stimulation and transcranial magnetic stimulation.
The non-invasive nerve monitoring device, A device for neurological monitoring of cerebral hemodynamics, The system according to any one of claims 1 to 5 , further comprising one or more devices for measuring electrical signals generated by neurons in order to measure brain activity.
A device for calibrating cerebral hemodynamics, (i) hemodynamic responses in a target region of interest of the brain of a human subject acquired by a non-invasive neurosurgical device, and (ii) an input unit configured to receive a hemodynamic brain atlas created by a system for creating a hemodynamic brain atlas for calibration of brain hemodynamics , wherein the hemodynamic brain atlas includes a plurality of brain regions, each brain region being associated with a hemodynamic response function represented by a set of parameters, A processing unit configured to calibrate the acquired hemodynamic response using the hemodynamic brain atlas, It includes an output unit configured to output the calibrated hemodynamic response, The aforementioned system, A non-invasive transcranial nerve stimulator configured to induce neural activity in a target region of interest of the brain of a human subject to induce a hemodynamic response, the non-invasive transcranial nerve stimulator having transcranial functional ultrasound stimulation, A non-invasive neuromonitoring device configured to monitor evoked hemodynamic responses in the aforementioned target region of interest, A computing device configured to determine a set of parameters representing the hemodynamic response function of the induced hemodynamic response in the target region of interest, and to associate the set of parameters of the hemodynamic response function with the target region of interest to form the hemodynamic brain atlas. It has, The non-invasive transcranial nerve stimulator is configured to induce multiple hemodynamic responses in multiple target regions of interest, and each hemodynamic response is induced in each target region of interest. The computing device is configured to determine a set of parameters representing the hemodynamic response function of each induced hemodynamic response, and to associate each of the sets of parameters with the target region of interest in which the induced hemodynamic response was triggered, thereby forming the hemodynamic brain atlas. Device.
The aforementioned hemodynamic brain atlas is Previous hemodynamic response function measurements of the aforementioned human subject, Previous hemodynamic response function measurements of a group of healthy adults, The apparatus according to claim 7, which can be derived from one or more previous hemodynamic response function measurements of a specific patient group and from one or more previous hemodynamic response function measurements of a single patient in which brain regions may be calibrated.
The apparatus according to claim 7 or 8 , wherein the region of interest is different from the plurality of brain regions of the hemodynamic brain atlas.
It is a neural monitoring system, A non-invasive neurosurveillance device for acquiring hemodynamic responses in target regions of interest of the brain of human subjects, A system comprising an apparatus according to any one of claims 7 to 9 for calibrating the acquired hemodynamic response.
A computer implementation method for calibrating cerebral hemodynamics, The steps include: receiving, by an input unit, (i) hemodynamic responses in a target region of interest of the brain of a human subject acquired by a non-invasive neurosurgical device, and (ii) a hemodynamic brain atlas prepared by a method for preparing a hemodynamic brain atlas for calibration of brain hemodynamics , wherein the hemodynamic brain atlas has one or more brain regions, each brain region associated with each hemodynamic response function, which is represented by a set of parameters; The processing unit performs the steps of calibrating the acquired hemodynamic response using the hemodynamic brain atlas, The process includes the step of outputting the calibrated hemodynamic response using an output unit , The aforementioned method further, A non-invasive transcranial nerve stimulator is used to induce neural activity in a target region of interest of the brain of a human subject, wherein the non-invasive transcranial nerve stimulator has transcranial functional ultrasound stimulation. The steps include monitoring the evoked hemodynamic response in the target region of interest using the non-invasive neuromonitoring device, The steps include: determining a set of parameters representing the hemodynamic response function of the induced hemodynamic response in the target region of interest using a computing device; The computing device performs the steps of associating the set of parameters of the hemodynamic response function with the target region of interest to form the hemodynamic brain atlas. It has, The non-invasive transcranial nerve stimulator is configured to induce multiple hemodynamic responses in multiple target regions of interest, and each hemodynamic response is induced in each target region of interest. The computing device is configured to determine, for each induced hemodynamic response, a set of parameters representing the hemodynamic response function of the induced hemodynamic response, and to associate each of the sets of parameters with the target region of interest in which the induced hemodynamic response was induced, thereby forming the hemodynamic brain atlas .
A computer program for controlling the system described in any one of claims 1 to 6 or the apparatus described in any one of claims 7 to 9 , the computer program configured to perform the method described in claim 11 when executed by a processor.

Description

This invention relates to the calibration of cerebral hemodynamics, and more particularly to a system for creating a hemodynamic brain atlas for cerebral hemodynamic calibration, an apparatus for cerebral hemodynamic calibration, a neurological monitoring system, a method for creating a hemodynamic brain atlas, a computer-based method for cerebral hemodynamic calibration, and computer program elements. Functional magnetic resonance imaging (fMRI) is limited by the use of a standard hemodynamic response function (HRF) across the brain. The use of a single canonical HRF (which is the same across the entire brain and across individual brain regions) may be a limitation. The limitations of the standard HRF can be partially mitigated by event-responsive HRF parameter estimation (HRF calibration). However, this calibration can only be performed in brain regions that have a close connection between the event and the evoked neural activity, i.e., the visual cortex. US 2017/340260 A1 describes a system for determining neurovascular responses to brain stimulation. U.S. Patent Application Publication 2014/058247 describes a method for acquiring brain activity information from a living organism subjected to visual stimulation. Suh M et al.'s "Blood volume and hemoglobin oxygenation response following electrical stimulation of human cortex" (NeuroImage, Elsevier, Amsterdam, NL, vol. 31, no. 1, 15 May 2006, pages 66-75) reports the first measurement of deoxygenated hemoglobin in humans with high spatial and temporal resolution. An example of a system for creating a hemodynamic brain atlas for the calibration of cerebral hemodynamics is outlined below.This document outlines an example of using the tFUSMRI system to create a hemodynamic brain atlas.This document outlines an example of using the tFUSMRI system to create a hemodynamic brain atlas.This document outlines an example of using the tFUSMRI system to create a hemodynamic brain atlas.Further examples of systems for creating hemodynamic brain atlases for cerebral hemodynamic calibration are outlined.A schematic diagram of a device for calibrating cerebral hemodynamics is shown.An example of a neural monitoring system is shown in schematic form.This shows a flowchart of the method for creating a hemodynamic brain atlas for the calibration of cerebral hemodynamics.A flowchart of methods for calibrating cerebral hemodynamics is shown. Functional magnetic resonance imaging (fMRI) is a non-invasive tool used to measure neural activity in response to stimuli, tasks, or resting conditions. Unfortunately, fMRI does not directly measure neuronal activity, i.e., the action potential of single-cell neurons, but rather relies on the coupling between neuronal metabolism and blood flow. Functional MRI sequences typically use blood oxygen level-dependent (BOLD) contrast to estimate brain activity. Therefore, fMRI relies on the response of blood vessels in the brain and is thus limited and transiently filtered by the hemodynamics of the brain's vascular system. Event-associated fMRI studies identify the brain's standard hemodynamic response function (HRF). An event, such as the presentation of a short visual stimulus, elicits nearly instantaneous neuronal activity in the visual cortex. In contrast to this neuronal activity, HRF is delayed. In the visual cortex, the stimulus elicits a delayed increase in the BOLD signal due to vasodilation and a massive influx of oxygenated blood. This significant increase in signal is the primary source of fMRI. HRF typically peaks approximately 6 seconds after the visual stimulus. After about 15–20 seconds, HRF slowly returns to baseline. HRF can be used to estimate brain activity in task-based fMRI by convolution with stimulus or task events. Furthermore, HRF can be used to deconvolve fMRI time series to estimate neuronal events and task-induced changes in brain connectivity. In short, HRF is a critical component of fMRI for linking changes in the BOLD signal to events, and vice versa. The use of a single canonical HRF is considered a limitation because it is identical across the brain and from individual to individual. Furthermore, HRF function has also been shown to be age-dependent. The aforementioned limitations, such as the use of a single canonical HRF across the entire brain and individual regions, can be partially mitigated by estimating HRF parameters in response to specific events, i.e., HRF calibration. However, this calibration can only be performed in brain regions where there is a close coupling between these events and evoked neural activity. For example, the visual cortex exhibits a reliable response to visual stimuli. Using fMRI and presentation of visual stimuli, HRF can be deconvoluted in the visual cortex, and individualized HRF parameters can be derived. Similarly, HRF can be estimated for auditory and sensory motor regions. However, most brain regions do not reliably modulate neural activity in response to stimuli. As a resul