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JP-7856350-B1 - Non-invasive measurement device for separating venous and arterial blood biochemical components.

JP7856350B1JP 7856350 B1JP7856350 B1JP 7856350B1JP-7856350-B1

Abstract

[Problem] To provide technology for the practical application of a non-invasive photoacoustic measuring instrument that can accurately separate and measure the biochemical components of venous and arterial blood. [Solution] The blood biochemical component photoacoustic vascular separation analyzer of the present invention comprises a light emitter 17 that emits light of specific wavelengths corresponding to blood biochemical components such as glucose, water, and blood components in veins and arteries, a vibration detector 18 that detects acoustic waves from the living body when the light from the light emitter 17 is irradiated onto the living body at specific wavelengths, and a control unit 11 that processes the signals from the vibration detector 18 for each of the specific wavelengths and outputs the result. [Selection Diagram] Figure 1

Inventors

  • 立野 洋人

Assignees

  • 株式会社JSV

Dates

Publication Date
20260511
Application Date
20251017

Claims (7)

  1. Light emitters that emit light of specific wavelengths corresponding to blood biochemical components, water, and blood components in veins and arteries, respectively. A vibration detector that irradiates a living organism with light from the light emitter at specific wavelengths and detects acoustic waves from the living organism as vibrations, and A control unit that processes the signal from the vibration detector for each specific wavelength and outputs the signal, Equipped with , A metal flange is provided between the vibration detector and the light emitter. An elastic body is provided on the flange, and the vibration detector is positioned via the elastic body. A photoacoustic blood biochemical component vascular separation analyzer in which the vibration detector and the flange end face are in contact with the living body, but the light emitter is positioned at a distance .
  2. The vibration detector comprises a vibrator and a metal case surrounding the vibrator, as described in claim 1 of the blood biochemical component photoacoustic vascular separation analyzer.
  3. The blood biochemical component photoacoustic vascular separation analyzer according to claim 1 , wherein the signal processing in the control unit involves dividing the depth-direction signal intensity measured in the depth direction of the living body by the signal intensity of the living body surface measured at the natural frequency of the vibration detector.
  4. The blood biochemical component photoacoustic vascular separation analyzer according to claim 1 or 3, wherein the control unit separates and measures blood biochemical components in veins and arteries based on signals from vibration detectors when light of a specific wavelength corresponding to blood components in veins and arteries is irradiated, respectively.
  5. The blood biochemical component photoacoustic vascular separation measuring instrument according to claim 4, wherein the control unit calculates the amount of blood biochemical components corresponding to the positions of veins and arteries based on the signal intensity from the vibration detector when light of a specific wavelength corresponding to water and blood biochemical components is irradiated, respectively .
  6. The photoacoustic blood biochemical component vascular separation analyzer according to claim 1 or 2 , wherein the light emitter outputs a light pulse with a pulse width of 1/3 to 1/100 of the light emission period .
  7. The blood biochemical component photoacoustic blood vessel separation analyzer according to claim 1 or 2, wherein the blood biochemical component is at least one selected from the group consisting of glucose, triglycerides, total protein, creatinine, and urea, and the light emitter comprises a light emitter that emits light of a specific wavelength corresponding to the blood biochemical component .

Description

This invention relates to a photoacoustic measuring instrument for non-invasively separating and measuring the biochemical components of venous and arterial blood. While measurement devices using photoacoustic effects have been reported previously, non-invasive blood glucose meters, for example, have yet to be put into practical use. This is because it has been impossible to separately measure the effects of variations in the mixing ratio of arterial and venous blood in non-blood samples. Furthermore, there are challenges in terms of measurement accuracy. To solve these problems, the inventor has invented a non-invasive blood glucose measuring device using a resonant vibration detector and a correlation detector to improve sensitivity and signal-to-noise ratio using photoacoustic resonance and to obtain depth analysis, and has filed a patent application (Patent Document 1). However, Patent Document 1 did not disclose details of the detector configuration or control procedure, making practical application difficult. Japanese Patent Publication No. 2004-249025 This is a block diagram of a photoacoustic blood glucose meter.The images show a top view (a) and a cross-sectional view (b) of the light emitter and vibration detector in a photoacoustic blood glucose monitor.This graph shows the measurement results of photoacoustic signals in the direction of deep body tissue using characteristic wavelengths (760 nm and 570 nm) for deoxyhemoglobin and oxyhemoglobin. The vertical axis represents signal intensity, and the horizontal axis represents frequency and its value converted to deep body depth.This graph shows the measurement results of the photoacoustic signal in the direction of body depth using the characteristic wavelength of water (1450 nm). The vertical axis represents the signal intensity, and the horizontal axis represents the frequency and its value converted to body depth.This graph shows the measurement results of the photoacoustic signal in the direction of deep body tissue using the characteristic wavelength (1200 nm) of glucose. The vertical axis represents the signal intensity, and the horizontal axis represents the frequency and its value converted to deep body depth. The photoacoustic blood vessel separation and measurement device for blood biochemical components of this embodiment will be explained using Figure 1. In the following description, blood glucose will be used as an example of a blood biochemical component, and a blood glucose meter for measuring blood glucose levels will be described; however, the present invention is not limited to this. The photoacoustic blood glucose meter in Figure 1 consists of a light emitter 17, a vibration detector 18, and a control unit 11. The light emitter 17 is composed of a diode with a variable illumination period that emits light of specific wavelengths corresponding to glucose, water, and blood components in veins and arteries, respectively, as blood biochemical components. However, it is not limited to this and may be composed of a semiconductor laser or the like. Furthermore, the blood components in veins and arteries may be any blood components specific to veins and arteries, for example, deoxyhemoglobin and oxyhemoglobin. In this case, a diode emitting light with absorption wavelengths of 760 nm and 570 nm can be used as the light emitter 17. In Figure 1, the vibration detector 18 is composed of, for example, a PZT (Personal Light-emitting Telescope). Light from the light emitter 17 is irradiated onto the living body, i.e., the human body being measured 113, at specific wavelengths, and acoustic waves from the human body being measured 113 are detected. In Figure 1, the control unit 11 processes the signal from the vibration detector 18 for each specific wavelength and outputs it. Specifically, the acoustic wave signal from the vibration detector 18 is amplified by the tuning amplifier 19, input to the correlation detector 110, and then processed by the A/D converter 112 before being controlled by the CPU 13 to control the display. The CPU 13 controls the synthesizer 14, the diode light emission power controller 15, and the diode array switch 16. Specifically, the CPU 13 controls the timing synthesizer 14 that causes the light emitter 17 to emit light, outputs a timing reference signal 111 to the correlation detector 110, and the correlation detector 110 detects an acoustic wave signal based on this reference signal 111, enabling deep body depth exploration by specifying frequency undermodulation. Furthermore, the CPU 13 sets a measurement frequency ft for the synthesizer 14 to determine the subcutaneous depth measurement point. Based on this signal, the CPU 13 controls the diode light emission power controller 15 to specify a specific light emission power and wavelength. The light emission pulse width is set to 1/4 of the emission period, which is determined by the photoacoustic generation high efficiency width and correlation detection, enabling