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JP-7857055-B2 - Slide scanning device and its operating method

JP7857055B2JP 7857055 B2JP7857055 B2JP 7857055B2JP-7857055-B2

Inventors

  • パク，ミンソプ
  • ペク，ドンヨプ
  • シン，チェ・ホン
  • イ，ボム・ジュン
  • イム，ヨンヨン

Assignees

  • クリオシス インコーポレイテッド

Dates

Publication Date
20260512
Application Date
20240725
Priority Date
20230725

Claims (10)

  1. A slide tray slot for accommodating one or more slide trays, A fork for transporting the aforementioned slide tray, A preview camera that acquires a preview image of the slide tray, An optical device for acquiring scanned images of one or more slides placed in the slide tray, The display and Memory for storing one or more instructions, A slide scanning device comprising at least one processor that performs one or more instructions stored in the memory, The display is provided on the door of the slide scanning device. The at least one processor performs the one or more instructions, A slide scanning device that controls the display to output an image for at least one of the preview image and the scanned images of one or more slides.
  2. The aforementioned fork is The slide scanning apparatus according to claim 1, characterized in that it extracts the slide tray housed in the slide tray slot and transports it to at least one of the positions where the preview image can be acquired and the positions where the scan image can be acquired.
  3. The scanned images of the aforementioned one or more slides are The slide scanning apparatus according to claim 1, characterized in that it is acquired after acquiring the aforementioned preview image.
  4. The slide scanning device, The system further includes a shuttle positioned at a location corresponding to the optical device, The aforementioned shuttle, The slide scanning device according to claim 1, characterized in that it moves in the xy plane to acquire a scanned image of one or more slides.
  5. The optical device is It includes a scanning camera, a microscope tube, a z-axis transfer unit, and an objective lens. The aforementioned objective lens is, The slide scanning device according to claim 1, characterized in that the z-axis transfer unit moves along the z-axis according to an autofocus algorithm.
  6. The aforementioned door is The slide scanning device according to claim 1 , characterized in that it is installed in a slidable manner.
  7. A slide scanning method for a slide scanning apparatus according to any one of claims 1 to 6 , The steps include obtaining a scan request for the first slide tray, The steps include: moving the fork to a position where a preview image can be acquired, the first slide tray housed in the slide tray slot is moved to a position where a preview image can be acquired; The steps include: the preview camera acquiring a preview image of the first slide tray; The steps include: the fork moving the first slide tray to a position where a scan image can be acquired; A method comprising the step of the optical device acquiring a scanned image of one or more slides arranged in the first slide tray.
  8. The step of the fork moving the first slide tray to a position where a scan image can be acquired is: The method according to claim 7 , comprising the step of the fork transferring the first slide tray to a shuttle.
  9. The step of the optical device acquiring a scanned image of one or more slides placed on the first slide tray is: ( a ) A step of extracting the ROI (region of interest) of the first slide, ( b ) A step of performing IAF (Image Autofocusing) at a first location of the ROI to determine a reference focal point (RFP), ( c ) A step of performing Laser Autofocus (LAF) at a second location of the ROI based on the determined RFP, The method according to claim 7 , comprising the step of ( d ) obtaining a scanned image of the ROI of the first slide by repeating step (c) for the entire ROI of the first slide.
  10. A program stored on a recording medium that can be read by a computer to perform the method described in claim 7 on a computer.

Description

This disclosure relates to a slide scanning device and its operating method. The Department of Pathology plays a crucial role in providing a foundation for clinicians' treatment plans by observing and analyzing morphological changes in patients' cells, tissues, and tissue fluids to make diagnoses. While traditional cytological or histological examinations in the Department of Pathology typically involved specialists visually interpreting patient cell or tissue slides using a microscope, recently, digital slide scanners have been introduced into pathological diagnosis. In addition to microscopic diagnosis, pathological diagnoses are now being performed using digital images obtained by scanning cell or tissue staining slides. Slides containing patient specimens are placed in a tray, the slide tray is placed in a slide tray slot, and the slide tray placed in the slide tray slot is scanned by a digital slide scanner or similar device. The scan is then performed, and information about the slides in the slide tray is obtained, allowing for pathological diagnosis. To acquire more information from slides in a shorter time, much research is being conducted on automating slide scanning devices. This is an illustrative diagram of a slide scanning device according to one embodiment of the present disclosure.This is a diagram showing the internal configuration of a slide scanning device according to one embodiment of the present disclosure.This is an illustrative diagram of a slide scanning device for acquiring a preview image according to one embodiment of the present disclosure.This is a drawing illustrating a method for extracting or inserting a slide tray from a slide tray slot according to one embodiment of the present disclosure.This is a drawing showing a slide tray, according to one embodiment of the present disclosure, being transported to a shuttle.This is a drawing illustrating a method for obtaining a scanned image according to one embodiment of the present disclosure.These drawings illustrate a method for determining a reference focal length (Reference Focus Position; RFP) according to one embodiment of the present disclosure.This is an example graph of peak information according to one embodiment of the present disclosure.This is a drawing showing a camera module that performs an autofocus procedure according to one embodiment of the present disclosure.This is a flowchart illustrating a method for scanning slides using a slide scanning device according to one embodiment of the present disclosure.This is a block diagram of a slide scanning device according to one embodiment of the present disclosure.This is an illustrative diagram of a slide scanning device according to one embodiment of the present disclosure.This is a drawing illustrating a slide tray according to one embodiment of the present disclosure.This is a drawing illustrating a slide according to one embodiment of the present disclosure.This is a drawing illustrating a slide scanning device according to one embodiment of the present disclosure.This diagram illustrates a method for extracting an ROI (Region of Interest) according to one embodiment of the present disclosure.This flowchart shows a method for scanning an ROI according to one embodiment of the present disclosure.This diagram illustrates a method for determining a first point for performing passive autofocus according to one embodiment of the present disclosure.This diagram illustrates a method for determining a first point for performing passive autofocus according to one embodiment of the present disclosure. To clarify the technical concept of this disclosure, embodiments of this disclosure will be described in detail with reference to the accompanying drawings. Where it is determined that a specific description of a related known function or component would unnecessarily obscure the gist of this disclosure, such detailed description will be omitted. Components having substantially the same functional configuration in the drawings have been assigned the same reference numerals and symbols whenever possible, even if they appear in other drawings. For convenience of explanation, the apparatus and method will be described together where necessary. The operations of this disclosure do not necessarily have to be performed in the order described, and may be performed in parallel, selectively, or individually. The terminology used in the embodiments of this disclosure has been selected to be as widely used and general as possible, taking into account the function of this disclosure; however, this may change depending on the intent of the articulators, case law, the emergence of new technologies, etc. In certain cases, the applicant may have arbitrarily selected some terms, in which case their meaning will be described in detail in the description of the embodiment. Therefore, the terms used herein must be defined not merely as names of terms, but based on their meaning and the overall conte