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JP-7857331-B2 - Pre-prepared tissue grafts with attachment points

JP7857331B2JP 7857331 B2JP7857331 B2JP 7857331B2JP-7857331-B2

Inventors

  • ダイスター，カート アンドリュー
  • ティンネメイヤー，ジョナサン アンドリュー
  • グラヤム，カーク マイケル
  • ヒリアー，シェイマス

Assignees

  • アクソジェン コーポレーション

Dates

Publication Date
20260512
Application Date
20240314
Priority Date
20180412

Claims (8)

  1. It is a membrane tissue graft, One or more pre-fabricated attachment points, The system comprises a reinforcing region provided only around one or more pre-fabricated attachment points, Each reinforced region is visually distinguished from the rest of the membrane tissue graft in order to increase the visibility of the one or more pre-fabricated attachment points. Each reinforced region is formed of the same material as the material forming the other parts of the membrane tissue graft. The one or more pre-fabricated attachment points are membrane tissue grafts, each containing one or more etchings .
  2. The membrane tissue graft according to claim 1, wherein the one or more pre-fabricated attachment points include one or more pre-fabricated suture holes or incisions.
  3. The membrane tissue graft according to claim 1, wherein the membrane tissue graft has a thickness of 25 microns to 3 millimeters.
  4. The membrane tissue graft according to claim 1, wherein the membrane tissue graft comprises natural material.
  5. The membrane tissue graft according to claim 4, wherein the natural material is selected from one or more of the following: porcine small intestine submucosa, amniotic membrane/chorionic membrane, reconstituted denatured collagen, collagen, elastin, thrombin, fibronectin, starch, poly(amino acids), gelatin, alginate, pectin, fibrin, oxidized cellulose, chitin, chitosan, tropoelastin, hyaluronic acid, fibrin-based materials, collagen-based materials, hyaluronic acid-based materials, glycoprotein-based materials, cellulose - based materials, silk, and combinations thereof.
  6. The membrane tissue graft according to claim 1, wherein the membrane tissue graft comprises a synthetic material.
  7. The membrane tissue graft according to claim 6, wherein the synthetic material is selected from one or more of the following: silicone resin, stretched polytetrafluoroethylene (ePTFE), polyethylene terephthalate tetraphthalate (Dacron®), polyurethane aliphatic polyester, poly(amino acid), poly(propylene fumarate), copro(ether ester), polyalkylene oxalate, polyamide, tyrosine-derived polycarbonate, poly(iminocarbonate), polyorthoester, polyoxaester, polyamide ester, polyoxaester containing an amine group, poly(anhydride ) , polyphosphazene, and mixtures thereof.
  8. The membrane tissue graft according to claim 1, further comprising one or more bioactive components that facilitate the repair of damaged tissue.

Description

This application claims the benefits of U.S. Provisional Application No. 62/656,735, filed on 12 April 2018, the contents of which are incorporated herein by reference. This application relates to a tissue graft, and more specifically to a tissue graft having pre-fabricated attachment points (mounting points). Membrane tissue grafts are often used as a matrix (substrate) for tissue repair or regeneration, particularly for soft tissue repair or regeneration. Typically, such tissue grafts are adhered to or sutured onto the damaged tissue. Once implanted, the tissue graft can protect the damaged tissue and aid in its growth and repair. The tissue graft can even be incorporated into the repaired tissue and become part of the repaired/regenerated tissue. Certain membrane tissue grafts are relatively mechanically robust and offer suitable mechanical properties for reinforcing soft tissue grafts. Suitable suture materials, particularly needles, for microsurgical applications in nerve repair are not always appropriate for fixing mechanically robust tissue-based membranes. For example, needles with larger diameters and sharper blades may be required to prevent bending in membrane tissue grafts. However, since microsurgical procedures are performed more effectively using thinner, tapered-point needles that can cause less tissue trauma during use, the use of such needles may be disadvantageous. Certain other membrane tissue grafts possess relatively weak mechanical properties to facilitate their use as buffering or lubricating materials. In such cases, the properties of the graft may be such that tearing or splitting occurs primarily due to the placement of sutures. Such tears or splits can easily propagate through the material, potentially leading to mechanical failure. Certain membrane tissue grafts may be formed into tubes, conduits, or other forms to support and enhance microsurgical repairs, such as the repair of damaged nerves. Due to the specialized needs of microsurgical repairs, the parameters of sutures and suture needles may be important for the surgical procedure. Examples of one or more pre-fabricated attachment points (e.g., one or more pre-fabricated etchings and one or more pre-fabricated suture holes) in an exemplary membrane tissue graft of the present disclosure are shown.The diagram shows exemplary shapes and forms of suture holes. In each embodiment, the filled area toward the center indicates a hole or cut. The white area around the hole indicates an optional etching. Additionally, the shaded area surrounding the white area indicates an optional reinforcement area.The present invention illustrates one or more pre-fabricated attachment points, in particular one of various configurations of one or more pre-fabricated holes or suture holes placed on a membrane tissue graft, consistent with embodiments of the present disclosure.The present invention illustrates one or more pre-fabricated attachment points, in particular one of various configurations of one or more pre-fabricated holes or suture holes placed on a membrane tissue graft, consistent with embodiments of the present disclosure.The present invention illustrates one or more pre-fabricated attachment points, in particular one of various configurations of one or more pre-fabricated holes or suture holes placed on a membrane tissue graft, consistent with embodiments of the present disclosure.The present invention illustrates one or more pre-fabricated attachment points, in particular one of various configurations of one or more pre-fabricated holes or suture holes placed on a membrane tissue graft, consistent with embodiments of the present disclosure.The present invention illustrates one or more pre-fabricated attachment points, in particular one of various configurations of one or more pre-fabricated etchings or markings placed on a membrane tissue graft, consistent with embodiments of the present disclosure.The present invention illustrates one or more pre-fabricated attachment points, in particular one of various configurations of one or more pre-fabricated etchings or markings placed on a membrane tissue graft, consistent with embodiments of the present disclosure.The present invention illustrates one or more pre-fabricated attachment points, in particular one of various configurations of one or more pre-fabricated etchings or markings placed on a membrane tissue graft, consistent with embodiments of the present disclosure.The present invention illustrates one or more pre-fabricated attachment points, in particular one of various configurations of one or more pre-fabricated etchings or markings placed on a membrane tissue graft, consistent with embodiments of the present disclosure.Examples of the membrane tissue grafts of this disclosure in nerve repair protector tissue grafts are shown.Examples of the membrane tissue grafts of this disclosure in nerve repair connector tissue grafts are shown. In some specific exemplary embodiments, the p