KR-102930926-B9 - Functional composition for relieving hangover containing Orostachys japonica extract as an active ingredient

Abstract

The present invention relates to a functional composition for relieving hangovers comprising an extract of * Orostachys japonica * as an active ingredient. It was confirmed that when the *Orostachys japonica* of the present invention is extracted by applying a roasting process and a spray drying process, the antioxidant activity, alcohol dehydrogenase activity, and acetaldehyde dehydrogenase activity are significantly increased. Therefore, the *Orostachys japonica* extract of the present invention may be used as a food for relieving hangovers, a health functional food, or a pharmaceutical composition.

Inventors

• 현지연
• 박준서

Assignees

• (주)파이토에코

Dates

Publication Date

20260508

Application Date

20230801

Claims (5)

1. In a food composition for relieving hangovers containing Wason extract as an active ingredient, The above extract is, (1) A step of roasting the pine needles at 180 to 190℃ for 3 to 10 minutes; (2) Roasted pine needles are mixed with 15 to 30% ethanol as a solvent, at a ratio of 5 to 20 parts by weight of solvent per 1 part by weight of pine needles, for 6 to 12 hours. Extraction step; (3) The step of preparing a pine needle extract by adding 10 to 30 weight% of maltodextrin relative to the weight of the extract from step (2) and spray-drying at 180 to 220℃ after extraction, and The above composition is, A food composition for relieving hangovers characterized by increased alcohol dehydrogenase activity, acetaldehyde dehydrogenase activity, and antioxidant activity.
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4. In a health functional food composition for relieving hangovers containing Wason extract as an active ingredient, The above extract is, (1) A step of roasting the pine needles at 180 to 190℃ for 3 to 10 minutes; (2) Roasted pine needles are mixed with 15 to 30% ethanol as a solvent, at a ratio of 5 to 20 parts by weight of solvent per 1 part by weight of pine needles, for 6 to 12 hours. Extraction step; (3) The step of preparing a pine needle extract by adding 10 to 30 weight% of maltodextrin relative to the weight of the extract from step (2) and spray-drying at 180 to 220℃ after extraction, and The above composition is, A health functional food composition for hangover relief characterized by increased alcohol dehydrogenase activity, acetaldehyde dehydrogenase activity, and antioxidant activity.
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Description

Functional composition for relieving hangover containing Orostachys japonica extract as an active ingredient The present invention relates to a functional composition for relieving hangovers comprising an extract of * Orostachys japonica * as an active ingredient. A hangover refers to the side effects of alcohol consumption, characterized by symptoms such as thirst, headache, muscle pain, nausea, and vomiting, resulting from the metabolic processes of the alcohol. Although the exact scientific cause of a hangover has never been definitively announced, the prevailing theory has been that it is caused by acetaldehyde, a byproduct of ethanol breakdown; furthermore, research is emerging suggesting that ethanol itself is the cause of a hangover. Specifically, when a small amount of alcohol is consumed under normal conditions, ethanol entering the liver is converted into acetate through the action of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) within the cell cytosol, and this acetate is then excreted from liver cells via the circulatory system. In particular, acetaldehyde, the primary metabolite of ethanol, is known to be the main causative agent of alcoholic liver disease due to its significantly higher reactivity and potent toxicity compared to ethanol. Meanwhile, as economic and cultural standards improve, alcohol consumption is on the rise alongside the introduction of Westernized dietary habits. Chronic alcohol consumption not only causes damage to liver cells, which play a crucial role in metabolism, but can also have a fatal impact on major organs such as the gastrointestinal tract, pancreas, brain, nervous system, endocrine system, hematopoietic system, and immune system. Due to excessive and frequent drinking, which are characteristics of drinking culture, many people are interested in drugs that can eliminate hangovers. To alleviate such hangovers, beverages in the form of drinks are being developed. These beverages utilize various herbal extracts, such as Hovenia dulcis extract (Korean Patent Publication No. 10-1997-0073403), Galhwa extract (Korean Patent Publication No. 10-1996-0000088), and Nogeun extract (Korean Patent Publication No. 10-1998-0000173), as the main ingredients for hangover relief. Furthermore, hangover relief beverages containing Korean pears and Hovenia dulcis as main ingredients are also emerging. The pear is used as an auxiliary ingredient along with other main ingredients, primarily for purposes such as hydration. Meanwhile, * Orostachys japonica *, also known as *Bawisol* or *Giwasol*, is a perennial herb belonging to the Crassulaceae family that is mainly distributed in Korea, China, and Japan. It is cultivated as a succulent plant and is also used as a medicinal herb. It grows to a height of about 10 cm, and its leaves are green, though sometimes tinged with purplish, and are succulent. It is particularly often seen on roof tiles, and it is called *Wasong* (瓦松), meaning "tile pine," because its growth resembles pine needles, flowers, or pine cones. It is primarily harvested in the summer, dried, and used as a medicinal herb or brewed into tea. Since ancient times, all parts of *Wasong*, including the flowers, have been used to treat malaria, hepatitis, eczema, dysentery, hemorrhoids, malignant boils, and burns. It is also known to be highly effective in drawing out pus when crushed and applied to boils or wounds. Therefore, in the present invention, the hangover relief efficacy of the pine needle extract was confirmed through experiments, and it was confirmed that it can be used as a food, a health functional food, or a pharmaceutical composition. Figure 1 is a figure showing the hangover relief effect of a wild pine extract depending on whether or not a roasting process is performed, in one embodiment of the present invention. Figure 2 is a figure showing the hangover relief effect of a pine needle extract according to extraction conditions (ratio of solvent added during extraction) in one embodiment of the present invention. Figure 3 is a figure showing the hangover relief effect of a pine needle extract according to extraction conditions (extraction time) in one embodiment of the present invention. Figure 4 is a figure showing the hangover relief effect of a pine needle extract according to extraction conditions (solvent concentration) in one embodiment of the present invention. Figure 5 is a figure showing the hangover relief effect of a pine needle extract according to spray drying conditions (temperature) in one embodiment of the present invention. Figure 6 is a figure showing the hangover relief effect of a pine needle extract according to spray drying conditions (excipients) in one embodiment of the present invention. Figure 7 is a figure showing a comparison of the hangover relief effects of Hovenia dulcis extract, which is well known to have hangover relief functionality, and the present invention’s Pine needle extract, in one embodiment of the pre