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KR-102961334-B1 - EXTERNAL PREPARATION

KR102961334B1KR 102961334 B1KR102961334 B1KR 102961334B1KR-102961334-B1

Abstract

[1] An infrared protective topical skin agent containing a plate-shaped metal oxide (A) with a thickness of 30 to 360 nm, a heat-insulating topical skin agent, a topical skin agent for inhibiting photoaging, a topical skin agent for inhibiting skin temperature rise, a topical skin agent for inhibiting fatigue, and a topical skin agent for inhibiting the production of active oxygen, and [2] a topical skin agent containing a plate-shaped metal oxide (A) with a thickness of 30 nm or more and 360 nm or less, and an aspect ratio of 50 or more and 300 or less, and a non-volatile oil (B), with a mass ratio [(A)/(B)] of 0.05 to 5.

Inventors

  • 후쿠이 다카시
  • 오카다 도모나리
  • 데지마 노리코
  • 가지와라 게이고

Assignees

  • 카오카부시키가이샤

Dates

Publication Date
20260507
Application Date
20191227
Priority Date
20181227

Claims (16)

  1. Containing a plate-like metal oxide (A) with a thickness of 30 nm or more and 360 nm or less, and a non-volatile oil (B), wherein the mass ratio [(A)/(B)] is 0.05 or more and 5 or less, The above plate-shaped metal oxide (A) is one or more selected from the group consisting of plate-shaped titanium oxide and plate-shaped zinc oxide, and The aspect ratio of the above metal oxide (A) is 50 or more and 300 or less, and The above non-volatile oil (B) is an external skin preparation for infrared protection, having an evaporation rate of less than 20% at 25°C for 6 hours, as measured by the method (1) below. Method (1): A filter paper with a diameter of 90 mm is placed in a glass petri dish with a diameter of 120 mm, 1 g of the sample is placed on the filter paper, and the sample is stored in a room (25°C) at 65 %RH. Then, the amount of evaporation is calculated by measuring the residue of the sample after 6 hours.
  2. Containing a plate-like metal oxide (A) with a thickness of 30 nm or more and 360 nm or less, and a non-volatile oil (B), wherein the mass ratio [(A)/(B)] is 0.05 or more and 5 or less, The above plate-shaped metal oxide (A) is one or more selected from the group consisting of plate-shaped titanium oxide and plate-shaped zinc oxide, and The aspect ratio of the above metal oxide (A) is 50 or more and 300 or less, and The above non-volatile oil (B) is an external skin preparation for shielding against infrared rays and heat, having an evaporation rate of less than 20% at 25°C for 6 hours as measured by the method (1) below. Method (1): A filter paper with a diameter of 90 mm is placed in a glass petri dish with a diameter of 120 mm, 1 g of the sample is placed on the filter paper, and the sample is stored in a room (25°C) at 65 %RH. Then, the amount of evaporation is calculated by measuring the residue of the sample after 6 hours.
  3. Containing a plate-like metal oxide (A) with a thickness of 30 nm or more and 360 nm or less, and a non-volatile oil (B), wherein the mass ratio [(A)/(B)] is 0.05 or more and 5 or less, The above plate-shaped metal oxide (A) is one or more selected from the group consisting of plate-shaped titanium oxide and plate-shaped zinc oxide, and The aspect ratio of the above metal oxide (A) is 50 or more and 300 or less, and The above non-volatile oil (B) is a topical skin preparation for protecting against infrared rays and inhibiting photoaging, having an evaporation rate of less than 20% at 25°C and 6 hours as measured by the method (1) below. Method (1): A filter paper with a diameter of 90 mm is placed in a glass petri dish with a diameter of 120 mm, 1 g of the sample is placed on the filter paper, and the sample is stored in a room (25°C) at 65 %RH. Then, the amount of evaporation is calculated by measuring the residue of the sample after 6 hours.
  4. Containing a plate-like metal oxide (A) with a thickness of 30 nm or more and 360 nm or less, and a non-volatile oil (B), wherein the mass ratio [(A)/(B)] is 0.05 or more and 5 or less, The above plate-shaped metal oxide (A) is one or more selected from the group consisting of plate-shaped titanium oxide and plate-shaped zinc oxide, and The aspect ratio of the above metal oxide (A) is 50 or more and 300 or less, and The above non-volatile oil (B) is a topical skin preparation for blocking infrared rays and suppressing skin temperature rise, having an evaporation rate of less than 20% at 25°C for 6 hours as measured by the method (1) below. Method (1): A filter paper with a diameter of 90 mm is placed in a glass petri dish with a diameter of 120 mm, 1 g of the sample is placed on the filter paper, and the sample is stored in a room (25°C) at 65 %RH. Then, the amount of evaporation is calculated by measuring the residue of the sample after 6 hours.
  5. Containing a plate-like metal oxide (A) with a thickness of 30 nm or more and 360 nm or less, and a non-volatile oil (B), wherein the mass ratio [(A)/(B)] is 0.05 or more and 5 or less, The above plate-shaped metal oxide (A) is one or more selected from the group consisting of plate-shaped titanium oxide and plate-shaped zinc oxide, and The aspect ratio of the above metal oxide (A) is 50 or more and 300 or less, and The above non-volatile oil (B) is a topical skin preparation for protecting against infrared rays and suppressing fatigue, having an evaporation rate of less than 20% at 25°C for 6 hours as measured by the method (1) below. Method (1): A filter paper with a diameter of 90 mm is placed in a glass petri dish with a diameter of 120 mm, 1 g of the sample is placed on the filter paper, and the sample is stored in a room (25°C) at 65 %RH. Then, the amount of evaporation is calculated by measuring the residue of the sample after 6 hours.
  6. Containing a plate-like metal oxide (A) with a thickness of 30 nm or more and 360 nm or less, and a non-volatile oil (B), wherein the mass ratio [(A)/(B)] is 0.05 or more and 5 or less, The above plate-shaped metal oxide (A) is one or more selected from the group consisting of plate-shaped titanium oxide and plate-shaped zinc oxide, and The aspect ratio of the above metal oxide (A) is 50 or more and 300 or less, and The above non-volatile oil (B) is a topical skin preparation for shielding against infrared rays and inhibiting the production of active oxygen, having an evaporation rate of less than 20% at 25°C for 6 hours as measured by the method (1) below. Method (1): A filter paper with a diameter of 90 mm is placed in a glass petri dish with a diameter of 120 mm, 1 g of the sample is placed on the filter paper, and the sample is stored in a room (25°C) at 65 %RH. Then, the amount of evaporation is calculated by measuring the residue of the sample after 6 hours.
  7. In any one of paragraphs 1 to 6, A topical skin preparation having a content of the above-mentioned plate-like metal oxide (A) of 1 mass% or more and 35 mass% or less.
  8. In any one of paragraphs 1 to 6, A topical skin preparation in which the above nonvolatile oil (B) is one or more selected from the group consisting of ester oil, silicone oil, hydrocarbon oil, higher fatty acid, and higher alcohol.
  9. In any one of paragraphs 1 to 6, A topical skin preparation, which is an oil-in-water emulsion composition and has a content of 10 mass% or more of the non-volatile oil (B).
  10. In any one of paragraphs 1 to 6, A skin external preparation, which is an aqueous type emulsion composition and has a content of 30 mass% or less of the nonvolatile oil (B).
  11. A method for protecting the skin from infrared radiation by applying a topical skin preparation for protecting against infrared radiation described in claim 1 to the skin.
  12. A method of insulating the skin by applying a topical skin preparation for insulating the skin described in claim 2 to the skin.
  13. A method for inhibiting photoaging of the skin, comprising applying a topical skin agent for inhibiting photoaging described in claim 3 to the skin.
  14. A method for suppressing skin temperature rise by applying a topical skin preparation described in claim 4 to the skin.
  15. A method for suppressing skin fatigue caused by solar irradiation, by applying a topical skin agent for suppressing fatigue described in claim 5 to the skin.
  16. A method for inhibiting the production of active oxygen in the skin by applying a topical skin preparation described in claim 6 to the skin.

Description

External preparation {EXTERNAL PREPARATION} The present invention relates to a topical skin agent for infrared protection, a topical skin agent for heat insulation, a topical skin agent for inhibiting photoaging, a topical agent for inhibiting skin temperature rise, a topical skin agent for inhibiting fatigue, a topical skin agent for inhibiting the production of active oxygen, and a topical skin agent. From the perspective of skin protection against sunlight, UV-protective cosmetics, such as sunscreens, are well-known. On the other hand, with the recent rise in health awareness, there is a demand for topical skin preparations that provide protection against infrared rays. Regarding topical skin preparations having infrared protection functions, for example, International Publication No. 2009/017104 (Patent Document 1) discloses a near-infrared damage prevention agent for biological tissues containing an infrared-transmitting shielding agent composed of titanium oxide powder and zinc oxide powder, as a technology relating to a prevention agent that inhibits infrared rays from reaching tissues deeper than the skin tissues and prevents damage to those tissues caused by infrared rays. In addition, Japanese Patent Publication No. 2017-95361 (Patent Document 2) discloses a near-infrared protection cosmetic composition comprising titanium oxide powder and zinc oxide powder, which combines excellent near-infrared protection effect and high transparency. [External use] The external agent (I) of the present invention is an infrared protective external agent, a heat-insulating external agent, a photoaging inhibitor external agent, a skin temperature rise inhibitor external agent, a fatigue inhibitor external agent, and a skin agent for inhibiting the production of active oxygen, containing a plate-shaped metal oxide (A) with a thickness of 30 nm or more and 360 nm or less. The external skin preparation (II) of the present invention contains a plate-shaped metal oxide (A) having a thickness of 30 nm or more and 360 nm or less and an aspect ratio of 50 or more and 300 or less, and a non-volatile oil (B), and a mass ratio [(A)/(B)] of 0.05 or more and 5 or less. In the description below, the various external preparations mentioned above may be collectively referred to as "external preparations." In the present invention, the thickness of the plate-shaped metal oxide refers to the length of the shortest axis of the plate-shaped metal oxide particle. In addition, in the present invention, infrared refers to electromagnetic waves with a wavelength of 780 nm to 1 mm. Among these, the external agent of the present invention is particularly excellent in its near-infrared protection effect with a wavelength of 780 nm to 2500 nm. By doing so, it is possible to suppress photoaging of the skin caused by sunlight irradiation, rise in skin temperature, skin fatigue caused by sunlight irradiation, and the production of active oxygen in the skin, thereby obtaining a higher heat shielding effect. In addition, in this specification, the infrared protection rate of a wavelength of 1500 nm is used as an indicator of the infrared protection effect. The topical agent of the present invention is a topical agent for infrared protection, heat insulation, inhibition of photoaging, inhibition of skin temperature rise, inhibition of fatigue, and inhibition of the production of reactive oxygen species, and is distinguished from topical skin agents for UV protection included in UV-blocking cosmetics, etc. By having an infrared protection effect, the topical agent of the present invention inhibits photoaging of the skin (wrinkles, sagging) or increase in skin temperature caused by irradiation such as infrared rays or sunlight containing light of wavelengths in the infrared region, skin fatigue caused by sunlight irradiation, and the production of reactive oxygen species in the skin, thereby enabling a higher heat insulation effect. However, as long as the topical agent of the present invention has the above effects, it may additionally have a UV protection effect. The formulation of the external agent of the present invention is not particularly limited, but it is preferred to be in the form of a liquid, gel, or cream for ease of application to the skin. The external agent may be in the form of an emulsion composition, and the emulsion composition may be either an oil-in-water type emulsion composition or an oil-in-water type emulsion composition. In addition, the external skin preparation of the present invention may be a skin cosmetic, such as a lotion, cream, emulsion, beauty serum, tanning product, or under-makeup cosmetic, in addition to being an external skin preparation for infrared protection. It is preferable that it be a skin cosmetic, as it does not easily turn white when applied to the skin, appears natural in appearance, and adheres well to makeup after application. <Plate-like metal oxide (A)> The external solvent of the present inven