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KR-102961931-B1 - RF hyperthemia system using RF catalyst

KR102961931B1KR 102961931 B1KR102961931 B1KR 102961931B1KR-102961931-B1

Abstract

A high-frequency hyperthermia treatment system using an RF catalyst (RC) is disclosed. The high-frequency hyperthermia treatment system using an RF catalyst comprises: one or more RF catalysts (RC) for nanomaterial antibody conjugation high-frequency hyperthermia treatment using RF frequency (RF + NP Ab Conjugation Cancer Therapy) attached to a target solid tumor site; an RF generator connected to a power supply unit and generating an RF frequency of 2.4 to 28 GHz to the one or more RF catalysts (RC) attached to the target solid tumor site; and a waveguide internal metasurface antenna connected to the RF generator and irradiating the RF frequency of 2.4 to 28 GHz to the one or more RF catalysts attached to the target solid tumor site. A high-frequency hyperthermia treatment system using RF catalysts has developed a new technology using an internal waveguide metasurface antenna for nanomaterial antibody conjugation high-frequency hyperthermia treatment (2.4, 5.8, 24 GHz RF + NP Ab Conjugation Cancer Therapy) using 2.4–28 GHz RF frequencies. It provides a high-frequency hyperthermia treatment device that binds to cancer cells in a target solid tumor site to which RF catalyst nanomaterials (NPs) are attached, using an SSPA connected to a computer, an RF generator transmitter, and 2.4, 5.8, and 24 GHz internal waveguide metasurface antennas. This is used in solid tumor treatment, in which 2.4–28 GHz RF frequencies are irradiated onto multiple RF catalysts (RCs) attached to the target solid tumor site using the internal waveguide metasurface antenna to kill cancer cells at a temperature of 41–45°C through heat generation.

Inventors

  • 김남영
  • 김은성

Assignees

  • 킴스바이오랩 주식회사

Dates

Publication Date
20260507
Application Date
20240912

Claims (20)

  1. One or more RF catalysts for nanomaterial antibody conjugation high-frequency hyperthermia using RF frequency (RF + NP Ab Conjugation Cancer Therapy) that attach to a site of a target solid tumor; and It includes an RF generator that generates a 2.4–28 GHz RF frequency to one or more RF catalysts (RC) attached to a portion of the target solid arm and connected to a power supply, and a waveguide internal metasurface antenna that is connected to the RF generator and irradiates a 2.4–28 GHz RF frequency to one or more RF catalysts attached to the portion of the target solid arm. A high-frequency hyperthermia treatment system using RF catalysts, which irradiates a plurality of RF catalysts attached to the target solid tumor site with an RF frequency of 2.4 to 28 GHz using a metasurface antenna inside the waveguide to kill cancer cells of the target solid tumor at a temperature of 41 to 45 ℃ by generating heat.
  2. In paragraph 1, A high-frequency hyperthermia treatment system using an RF catalyst, wherein the above solid tumors include skin cancer, stomach cancer, colorectal cancer, cervical cancer, kidney cancer, prostate cancer, breast cancer, brain tumor, lung cancer, liver cancer, uterine cancer, colon cancer, bladder cancer, and pancreatic cancer.
  3. In paragraph 1, The above meta-surface antenna is a 3D stacked metamaterial antenna provided inside the waveguide for high-frequency hyperthermia treatment of a solid tumor site, and the high-frequency hyperthermia treatment system using an RF catalyst, wherein the RF frequency uses an RF frequency in the range of 2.4 to 28 GHz to raise the temperature to 41 to 48°C.
  4. In paragraph 3, A high-frequency hyperthermia treatment system using an RF catalyst, wherein the RF frequency of the above metasurface antenna uses any one of 2.4 GHz, 5.8 GHz, or 24 GHz.
  5. In paragraph 1, The above RF catalyst is a high-frequency hyperthermia treatment system using an RF catalyst that generates heat of 41–45°C to cancer cells in a target solid tumor site as an RF absorber.
  6. In paragraph 5, The above RF catalyst, depending on frequency/power/time conditions, Catalyst: CuO, (2,450MHz,500W,30min), Catalyst: BaO, (2,450MHz,500W,30min), catalyst: , (2,450MHz,500W,7min), (10-15-20wt%)Pt/C catalyst: ,ethyleneglycol,KOH,carbon XC-72 (2,450MHz,700W,60s), (2-5-10wt%)M/SM=Au,Pd S= ,CuO,ZnO catalyst : or ), , or ,or , or PEG1450 or PVP40000 (33% of 650W, 390 cycles of 10s), Ru, catalyst: ,PVP,ethyleneglycol (225-450W, 2.5-7min), Ni-B/MgO catalyst: , , , ethylenediamine, NaOH, MgO (2,455MHz, 180W), Pd/multiwall carbon nanotube catalyst; ,Toluene, Carbon nanotube (10-20W, 2 min), catalyst: , ,grapheneoxide,CTBA,NaOH, ascorbicacid, (200W, 4min), catalyst: , HCl, , , (2x Pa,10min), Graphenenanosheets-ZnS nanocomposites catalyst: Graphene oxide nanosheets, , ,thioacetamide (400W,20min), or Pt/C catalyst: , or VulcanXC-72R, , NaOH, (50GHz,1400W,5min), Pt/carbon aerogel catalyst: ,ethyleneglycol,KOH, ,carbonaerogel powder (2,450MHz,800W,180s) /activated carbon catalyst: , ,activatedcarbon (2.45GHz,under temperature control,5min), Fe/ or S/ catalyst: ,isopropanol, , ,or (600W, 180℃ or 215℃, 30 or 60 min), Pt/carbon nanotube catalyst: ,ethyleneglycol,carbonnanotube,KOH, (2.45GHz,700W), Ag nanoparticles catalyst: Pectin, ,hexamine (2.45GHz,800W,5min), Ag IrAlloy nanoparticles catalyst: , , ethyleneGlycol,PVP(Under temperature control 197℃), catalyst: (2.45 GHz, 900W, 10 min), Catalyst: ( ), ( ), glycine (2.45 GHz, 800 W, 100 s), and sulfonic acid-functionalized catalysts: A high-frequency hyperthermia treatment system using an RF catalyst, using any one of the following RF catalysts: zeolite Na-Beta (Si/Al = 10), Na-mordenite (Si/Al = 6.5), montmorillonite K-10 (Si/Al = 2.7), and chlorosulfonylphenylethyltrimethoxysilane (40℃ for 2h).
  7. In paragraph 1, The above RF catalyst is MOF UIO-66- on a SiC substrate High-frequency hyperthermia treatment system using an RF catalyst.
  8. In paragraph 3, The above waveguide uses an open-ended waveguide having an opening formed at an end and a rectangular or circular structure with a perimeter that gradually narrows from the end. A high-frequency hyperthermia treatment system using an RF catalyst, wherein the 3D stacked metasurface antenna is attached to the inside of the waveguide using an adhesive member.
  9. In paragraph 8, The above 3D stacked metasurface antenna is k dielectric substrates, each having a metal pattern of the same shape formed on it; and the k dielectric substrates having the metal pattern formed thereon are stacked in a 3D stacked structure, A connector having k dielectric substrates having the above-mentioned metal pattern formed thereon and a (+) electrode to which electromagnetic waves are applied connected by a signal line, with the signal line provided on a cylindrical centerline; k dielectric substrates having the above metal pattern formed thereon and a ground provided on the outer edge surrounding the connector; and High-frequency hyperthermia treatment system using an RF catalyst including port1 and port2 for input and output.
  10. In Paragraph 9, A high-frequency hyperthermia treatment system using an RF catalyst, characterized in that the output of the metasurface antenna of the 3D stacked structure inside the waveguide is 0.1 to 1 kW.
  11. In Paragraph 9, The above 3D stacked metasurface antenna is a high-frequency hyperthermia treatment system using an RF catalyst, having a negative permittivity of 0 to -100 and a negative permeability of 0 to -100.
  12. In Paragraph 9, A high-frequency hyperthermia treatment system using an RF catalyst, characterized in that the k dielectric substrates collectively use one of a Teflon substrate, an FR4 substrate, or a Duroid substrate, and the thickness of each dielectric substrate is 0.1 to 10 mm.
  13. In Paragraph 9, A high-frequency hyperthermia treatment system using an RF catalyst, wherein the metal pattern formed on the above dielectric substrate uses any one of the metals gold (Au), platinum (Pt), silver (Ag), or copper (Cu).
  14. In Paragraph 9, A high-frequency hyperthermia treatment system using an RF catalyst, wherein various metal patterns formed on each of the k dielectric substrates are formed on the dielectric substrates such as a square border structure with a hollow center, a single circular ring with a hollow center, a square rhombus-shaped border structure with a hollow center, an octagonal circular ring structure with a hollow center, a triangle-shaped border structure with a hollow center, or a structure of ixj circular rings arranged in a horizontal (i)xvertical (j) array spaced apart from each circular ring with a hollow center.
  15. In Paragraph 9, A high-frequency hyperthermia treatment system using an RF catalyst, wherein the above connector uses an SMA connector or an N-type connector equipped with a signal line on a cylindrical inner centerline, and the signal line itself acts as a radiator as a (+) electrode-feed line.
  16. In Paragraph 9, The above grounding is a high-frequency hyperthermia treatment system using an RF catalyst, using any one of the metals aluminum (Al), gold (Au), platinum (Pt), silver (Ag), or copper (Cu).
  17. In Paragraph 9, A high-frequency hyperthermia treatment system using an RF catalyst, characterized in that the specific frequency band of the 3D stacked metasurface antenna is 2.4 to 28 GHz, and the bandwidth of the 3D stacked metasurface antenna is at least 1 MHz to 2 GHz.
  18. In paragraph 1, A high-frequency hyperthermia treatment system using an RF catalyst, characterized by using a metasurface antenna having a 3D stacked structure in which a plurality of dielectric substrates, each equipped with a metal pattern, are stacked and mounted inside an open-ended waveguide with a rectangular or circular structure having an opening formed at the end of the waveguide and a gradually narrowing perimeter, to integrate electromagnetic waves onto one or more RF catalysts (RCs, catalysts) attached to the target solid tumor area, and increasing the angle of frequency and the gain of the antenna.
  19. In paragraph 1, A high-frequency hyperthermia treatment system using an RF catalyst, wherein the above metasurface antenna can form various metal patterns on each of k dielectric substrates used in a 3D stacked structure, and the metal pattern is formed on the dielectric substrate in a structure of a square border with a hollow center, a single circular ring with a hollow center, a square rhombus-shaped border with a hollow center, or a number of circular rings (i is the number of circular rings in the horizontal direction, j is the number of circular rings in the vertical direction) arranged in a horizontal (i) x vertical (j) array spaced apart from each circular ring with a hollow center.
  20. In Paragraph 19, A high-frequency hyperthermia treatment system using an RF catalyst, wherein the above metasurface antenna can form various metal patterns on each of k dielectric substrates used in a 3D stacked structure, and the metal patterns are formed on the dielectric substrates using a metamaterial antenna in which a square border structure with a hollow center or a circular ring shape metal pattern with a hollow center is formed, or a 2.4 to 28 GHz RF frequency metamaterial array antenna.

Description

High-frequency hyperthermia treatment system using RF catalyst {RF hyperthemia system using RF catalyst} The present invention relates to a high-frequency hyperthermia treatment system using an RF catalyst (RC). More specifically, it involves the development of a novel technology utilizing an internal waveguide metasurface antenna for nanomaterial antibody conjugation high-frequency hyperthermia treatment (2.4, 5.8, 24 GHz RF + NP Ab Conjugation Cancer Therapy) using 2.4–28 GHz RF frequencies for high-frequency hyperthermia treatment on a target solid tumor site. The invention provides a high-frequency hyperthermia treatment device that conjugates to cancer cells in a target solid tumor site to which RF catalyst nanomaterials (NP, nanoparticles) are attached, by utilizing a Solid State Power Amplifier (SSPA) and an RF Generator transmitter connected to a computer and a power supply, along with 2.4, 5.8, and 24 GHz internal waveguide metasurface antennas. Furthermore, by irradiating 2.4–28 GHz RF frequencies onto multiple RF catalysts (RCs) attached to the target solid tumor site using the internal waveguide metasurface antenna, the temperature reaches 41–45°C due to heat generation. Used in solid tumor treatment systems that kill cancer cells at high temperatures, This relates to a high-frequency hyperthermia treatment system using an RF catalyst. Cancer treatment methods include surgery, radiation therapy, chemotherapy, immunotherapy, stem cell transplantation, targeted therapy, photodynamic therapy (PDT), and microwave therapy, which are used to treat various types of cancer. Photodynamic therapy (PDT) utilizes a photosensitizer to absorb light of a specific wavelength and an energy transfer mechanism ( This is a treatment method in which reactive oxygen species (ROS) are generated or heat is produced in the excited state through ), and free radicals generated by single oxygen are used to selectively kill cancer cells or kill them with the heat of a photocatalyst without causing any pain to the patient. However, the light (red light) used in photodynamic therapy (PDT) has limitations in that it can only penetrate the body to a depth of up to 10 mm and can be applied only to tumors located in superficial or localized areas. In addition, photodynamic therapy has limitations in selective delivery to tumor tissue due to inappropriate interactions between biomolecules or aggregation phenomena among photosensitizers. To address these problems, research is being conducted on technologies combined with various carrier systems, such as micelles, sealed liposomes, and biopolymers. Figure 1 shows a conventional cancer treatment method. First-generation chemotherapy drugs attack cancer cells by injecting toxic substances that inhibit cell division; however, they attack normal cells as well as cancer cells, leading to side effects such as vomiting and complications. Second-generation targeted anticancer drugs attack specific genes that cause targeted cancer, but they lead to drug resistance and are less effective in patients with metastatic cancer. Third-generation immunotherapy drugs utilize the body's immune system to activate immune cells and attack tumor cells; while they have low toxicity, they are effective for a limited number of patients, and although they have the fewest side effects, they have the disadvantage of being expensive. Fourth-generation metabolic anticancer drugs block the energy sources required by cancer cells, but further research is needed as there is currently only one commercially available treatment. Figure 2 shows the problems of existing anticancer treatments. According to Seoul National University Hospital, existing anticancer treatments have problems such as increased drug efflux, increased expression of anti-apoptotic proteins, denaturation of target proteins, and minimal efficacy against cold tumors, leading to the recurrence and metastasis of cancer due to anticancer drug resistance. As prior art related to this, Patent No. 10-1734928, "High-frequency hyperthermia cancer treatment device" is registered. The high-frequency hyperthermia cancer treatment device of FIG. 3a comprises: a main body (110) which is positioned upright and has a treatment space (111) provided inside with the center open to the front and rear, and a sliding groove (112) formed at the bottom of the treatment space (111), and has a built-in high-frequency module (113) that generates and outputs high-frequency current according to a control signal; a bed part (120) which is positioned horizontally, has a mat (121) mounted on its upper side, is inserted into the sliding groove (112), and slides forward and backward; and a grounding part (130) which is connected to the main body (110) by a cable and conducts high-frequency current applied to the skin (10) of a patient (U). The device includes: a treatment module (140) mounted on the upper position of the treatment space (111) on the main body (110), which moves along