KR-102962156-B1 - Probiotics for cognitive and mental health

Abstract

The present invention relates to a composition comprising Lactobacillus plantarum and to a method and use of said composition for preventing and/or treating mental illness, symptoms affecting mental health, and/or diseases associated with chronic stress in mammals. The present invention may be applied to restore and/or maintain and/or promote mental health (including cognitive health) and is potentially applicable, particularly in the fields of dietary and food supplements, medicines, and pharmaceuticals.

Inventors

• 레흐띠넨 마르꾸스
• 마오 웨??
• 스뗀만 로따

Assignees

• 인터내셔널 엔＆에이치 덴마크 에이피에스

Dates

Publication Date

20260507

Application Date

20191205

Priority Date

20181206

Claims (18)

1. Lactobacillus A bacterial strain of the species * plantarum* , wherein the bacterial strain is strain LP12151, which was deposited at DSMZ on January 9, 2018, under accession number DSM 32721.
2. Bacteria of the species Lactobacillus plantarum for use in the prevention and/or treatment of weight loss, mood swings, anxiety disorders and/or depression in mammals, wherein the bacteria of the species Lactobacillus plantarum is strain LP12151, which was deposited in DSMZ on January 9, 2018, under accession number DSM 32721.
3. A composition comprising a bacterial strain of the species Lactobacillus plantarum , wherein the bacterial strain is strain LP12151, which was deposited at DSMZ on January 9, 2018, under accession number DSM 32721.
4. A composition comprising bacteria of the species Lactobacillus plantarum for use in the prevention and/or treatment of weight loss, mood swings, anxiety disorders and/or depression in mammals, wherein the strain of Lactobacillus plantarum is strain LP12151, which was deposited at DSMZ on January 9, 2018, under accession number DSM 32721.
5. In paragraph 3, The above composition comprises additionally other bacterial strains.
6. In paragraph 3, The above composition is a composition that further comprises a prebiotic.
7. In paragraph 6, The above-mentioned prebiotic is a polydextrose, a composition.
8. In paragraph 3, The above composition is in the form of a food product, beverage, dietary supplement, or pharmaceutically acceptable formulation or composition.
9. In paragraph 3, The above composition is a spray-dried or freeze-dried composition.
10. In Paragraph 9, The above composition is a composition comprising a cryoprotective agent.
11. In paragraph 3, The above composition is in a unit dosage form, and the Lactobacillus plantarum strain is present in the composition in an amount of 10⁶ to 10¹² CFU per unit dosage.
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Description

Probiotics for cognitive and mental health The present invention relates to a bacterial strain of the species Lactobacillus plantarum, in particular without exclusion, the bacterial strain LP12151. The present invention also relates to a composition comprising Lactobacillus plantarum , in particular without exclusion, the bacterial strain LP12151. The present invention also relates to a composition comprising Lactobacillus plantarum , in particular without exclusion, the bacterial strain LP12151, for use in preventing and/or treating psychosis, symptoms affecting mental health, and/or diseases associated with chronic stress in mammals. The present invention also relates to methods and uses of bacterial strains of the species Lactobacillus plantarum and compositions comprising Lactobacillus plantarum , comprising food products, beverages, dietary supplements, and pharmaceutically acceptable formulations or compositions. Mental health relates to emotional, mental, physical, and social well-being. Our mental health status determines how we cope with stress. Psychosis can be defined as a health condition that alters an individual's thoughts, feelings, or behaviors (or all three) and causes distress and problems for the individual in social, work, or family activities. Psychosis encompasses a broad range of disorders related to anxiety, mood, psychosis, dietary behaviors, impulse control and addiction, personality, sociability, dissociativeness, obsessive-compulsive disorder, and post-traumatic stress. Each disorder alters human thoughts, feelings, and/or behaviors in distinct ways. Disorders such as Parkinson's disease, epilepsy, and multiple sclerosis are brain disorders, but they are considered neurological diseases rather than psychosis. Interestingly, the distinction between neurological diseases—including mild cognitive impairment, dementia, and memory disorders such as Alzheimer's disease—and psychosis is not clearly defined, and there is currently increasing evidence suggesting that psychosis is associated with changes in brain structure, chemistry, and function that underlie the development of neurological disorders. For example, the association between neurocognitive deficits and mood disorders is well established, so cognitive impairment in major depression may be similar to that observed in dementia (Reference [Rabins et al . Br J Psychiatry 1984; 144: 488-92]). Furthermore, untreated chronic stress can lead to serious health conditions, such as anxiety, muscle pain, hypertension, and a weakened immune system. Studies show that stress can contribute to the development of serious illnesses like heart disease, depression, and obesity. Symptoms of acute and chronic stress can manifest in the gastrointestinal tract, causing short-term and long-term effects on gastrointestinal function, respectively. Exposure to stress causes alterations within the gut-brain axis, ultimately leading to the development of a wide range of gastrointestinal disorders, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), other functional gastrointestinal diseases, food antigen-related adverse reactions, gastric ulcers, and gastroesophageal reflux disease (GERD). The major effects of stress on intestinal physiology include: 1) changes in gastrointestinal motility; 2) increased visceral sensation; 3) changes in gastric secretion; 4) increased intestinal permeability; and 5) negative effects on the regenerative capacity of the gastric mucosa and mucosal blood flow. and 6) alteration of intestinal microbial composition (reference [Konturek et al . J. Physiol Pharmacol. 2011; 62(6):591-9]). In relation to psychosis and associated neurocognitive decline and neurological disorders, strategies to achieve positive mental and cognitive health for an affluent and healthy life are now clearly emphasized. There is an increasing demand for nutritional therapies to achieve positive mental health without side effects. Current medications used to treat psychotic symptoms affecting mental health have many negative side effects, such as nausea, increased appetite and weight gain, fatigue, and gastrointestinal symptoms. Dietary supplements can represent an attractive means of achieving positive mental health and preventing the onset of symptoms of psychosis and related diseases. The gut-brain axis describes the bidirectional communication existing between the brain and the gut, and the microbiome-gut-brain axis underpins the role of the gut microbiome in this communication system. As outlined above, symptoms affecting psychosis and mental health are co-morbid with gastrointestinal disorders, and thus emotional and routine daily life stress can impair digestive function, and vice versa. There is growing evidence indicating that the gut microbiome has a profound influence on brain physiology, mental responses, and ultimately behavior (Reference [Dinan et al . J. Psychiatr Res. 2015, 63, 1-9]). Recent evidence suggests that pr