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KR-102962460-B1 - A health care salts containing high-concentration lithium carbonate and method of preparing therefor

KR102962460B1KR 102962460 B1KR102962460 B1KR 102962460B1KR-102962460-B1

Abstract

The present invention relates to a salt containing a high concentration of lithium carbonate and a method for manufacturing the same. The salt may be manufactured by a method comprising: (S10) a concentration step of concentrating lava seawater; (S20) a sodium carbonate mixing step of mixing sodium carbonate with the concentrated lava seawater of step (S10); (S30) a carbon dioxide injection step of injecting carbon dioxide at high pressure into the sodium carbonate mixture of step (S20); and (S40) a crystallization step of concentrating and crystallizing the carbon dioxide-injected mixture of step (S30). The salt according to the present invention contains a high concentration of lithium carbonate, so it has the effect of allowing one to consume lithium carbonate simply by directly consuming the salt or by adding the salt when cooking food, without the need to consume a separate lithium carbonate drug.

Inventors

  • 김용진
  • 한승훈

Dates

Publication Date
20260508
Application Date
20230726

Claims (6)

  1. (S10) A concentration step for concentrating lava seawater to a lithium concentration of 2.0 to 2.4 mg/L; (S20) A sodium carbonate mixing step in which 80 to 120 mL of an aqueous sodium carbonate solution is mixed with the concentrated lava seawater of step (S10) based on 1 L of lava seawater and stirred for 4 to 6 minutes; (S30) A carbon dioxide injection step in which carbon dioxide is injected at high pressure into the sodium carbonate mixture of step (S20) at a rate of 0.08 to 0.12 m³ /min to form lithium carbonate at a concentration of 40 to 60 mg/L; and (S40) A crystallization step of concentrating and crystallizing the carbon dioxide-injected mixture of the above (S30) step; a method for producing salt containing a high concentration of lithium carbonate, comprising A method for manufacturing a salt containing a high concentration of lithium carbonate, characterized in that the above salt contains 100 mg or more of lithium carbonate based on 1 kg of salt.
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  4. A salt containing a high concentration of lithium carbonate produced by the method of claim 1, The above salt is characterized by containing 100 mg or more of lithium carbonate based on 1 kg of salt.
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Description

A health care salt containing high-concentration lithium carbonate and method of preparing therefor The present invention relates to a salt containing a high concentration of lithium carbonate and a method for manufacturing the same. Depression is an emotional pathology that occurs regardless of objective circumstances. It is a disease in which the patient's entire life is overshadowed by a depressed mood, leading to decreased interest, anhedonia, psychomotor decline, pessimism, and despair, as well as suicidal urges that can even result in suicide attempts. It also manifests as various physical symptoms such as loss of appetite, insomnia, constipation, and decreased libido. Recently, depression has emerged as a serious social problem. Most current antidepressants have a pharmacological action that increases the concentration of neurotransmitters at central serotonin or norepinephrine synapses. Based on the mechanism by which they increase neurotransmitter concentrations, commonly used antidepressants include tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), and selective serotonin reuptake inhibitors (SSRIs). While these conventional antidepressants are relatively effective, some patients experience severe side effects or fail to meet expectations. There are also many patients who do not respond well to antidepressant medication (Thase et al. 2001), have high relapse rates (Frank et al. 1991), or are unable to take the medication due to severe side effects (Gumnick and Nemeroff 2000). Tricyclic antidepressants (TCAs), such as imipramine and desipramine, cause severe side effects including hypotension and cardiac dysfunction. Selective serotonin reuptake inhibitors, such as the most widely used fluoxetine and sertraline, cause nausea, gastrointestinal bleeding, or sexual dysfunction. Among lithium salts, lithium carbonate ( Li₂CO₃ ) has been used as a first-line treatment for mood stabilization and reduction of suicidality in bipolar disorder (BD) since the 1960s, providing acute anti-manic therapeutic relief and preventing BD recurrence in numerous BD patients (Baldessarini et al., 2006; Cipriani et al., 2013; Kessing et al., 2018; Roberts et al., 2017; Sani et al., 2017; Severus et al., 2014). Lithium is also known to act on Na+/K+ ATPase within neurons, alter the release of neurotransmitters, affect cAMP concentration, and block inositol metabolism, thereby causing neuronal depletion and inhibition. Figure 1 is a figure showing the presence and content of lithium carbonate contained in liquid salt prepared according to one embodiment of the present invention, confirmed by X-ray diffraction analysis. In one embodiment, the present invention provides a method for producing salt containing a high concentration of lithium carbonate. In a more specific embodiment, the method for producing salt containing a high concentration of lithium carbonate according to the present invention is, (S10) Concentration step for concentrating lava seawater; (S20) A sodium carbonate mixing step of mixing sodium carbonate into the concentrated lava seawater of the above (S10) step; (S30) A carbon dioxide injection step of injecting carbon dioxide at high pressure into the sodium carbonate mixture of the above (S20) step; and (S40) A crystallization step in which the carbon dioxide-injected mixture of the above (S30) step is concentrated and crystallized; characterized by including In the present invention, the salt containing a high concentration of lithium carbonate is characterized by containing 90 mg or more, preferably 100 mg or more, more preferably 100 to 250 mg, and more preferably 100 to 220 mg based on 1 kg of solid salt. The salt containing a high concentration of lithium carbonate according to the present invention contains a high concentration of lithium carbonate as described above. Therefore, it has the effect of allowing one to consume lithium carbonate by directly consuming the salt or by adding the salt during food preparation, without the need to consume lithium carbonate separately. Hereinafter, a method for manufacturing a salt containing a high concentration of lithium carbonate according to the present invention will be described in detail. delete delete (S10) Step is a concentration step for concentrating lava seawater. The aforementioned lava seawater refers to water that has been naturally filtered through basalt and sandy layers, flowing in and maturing over a long period; it is seawater found in the saline-salinity mixing zone (transition zone), where freshwater groundwater meets saltwater. In Korea, such lava seawater is distributed in areas including Jocheon-eup, Namwon-eup, and Seongsan-eup in Jeju Special Self-Governing Province, and its concentration decreases as one moves inland from the coast. As a specific example, the above lava seawater may be lava seawater extracted from a depth of 30 to 150 meters (relative to average sea level), preferably 44.35 meters, 86.35 meters,