KR-102962597-B1 - Composition comprising Musk rat Musk having inhibitory effect on Alcohol induced Liver Damage and Gastritis

KR102962597B1KR 102962597 B1KR102962597 B1KR 102962597B1KR-102962597-B1

Abstract

The present invention relates to a composition containing *Seohyang* that has an effect of improving gastritis and liver function, and is characterized by comprising 80% by weight of *Seohyang*, 10% by weight of camellia flower extract, 5% by weight of *Parachia nucifera* extract, 4% by weight of lacquer tree extract, and 1% by weight of fermented *Amur radish* leaf extract. It has the effect of improving liver function and inhibiting gastritis, and can be used as a functional food or food additive that can effectively inhibit hepatotoxicity and gastritis and has antioxidant activity.

Inventors

유영춘
류보렬

Assignees

주식회사 한웅

Dates

Publication Date: 20260512
Application Date: 20230927

Claims (4)

Comprising 80% by weight of Korean musk, 10% by weight of camellia flower extract, 5% by weight of Polygala tenuifolia extract, 4% by weight of lacquer tree extract, and 1% by weight of fermented Akebia quinata leaf extract, A composition containing musk that has the effect of improving gastritis and liver function.
In Article 1, The above-mentioned musk is prepared by adding 10 parts by weight of aronia vinegar, 5 parts by weight of coconut oil, and 1 part by weight of quercetin to 100 parts by weight of musk extracted from muskrat, treating with ultrasound for 5 minutes, and then centrifuging; The above aronia vinegar is, A step of obtaining an aronia extract by adding 10 parts by weight of aronia to 100 parts by weight of purified water, heating at 110℃ for 10 minutes, and then filtering; A step of adding 5 parts by weight of liquefaction enzyme to 100 parts by weight of the above aronia extract and liquefying at 60°C for 10 minutes; A step of adding 5 parts by weight of saccharifying enzyme to 100 parts by weight of the above-mentioned liquefied aronia extract and saccharifying at 60°C for 10 minutes; A step of adding 5 parts by weight of yeast to 100 parts by weight of the saccharified aronia extract and fermenting it alcoholically at 25°C for 2 days to obtain an alcoholic fermentation liquid; and A step of preparing an acetic acid fermentation liquid by adding 6 parts by weight of acetic acid bacteria to 100 parts by weight of the above alcohol fermentation liquid and fermenting it at 25°C for 7 days; using, manufactured including A composition containing musk that has the effect of improving gastritis and liver function.
In Article 1, The above camellia flower extract is obtained by adding 500 parts by weight of water to 100 parts by weight of camellia flowers and extracting at 1.6 atmospheres and 110℃ for 3 hours. The above Polygala tenuifolia extract is obtained by adding 600 parts by weight of 90% (v/v) ethanol to 100 parts by weight of Polygala tenuifolia, ultrasonically extracting for 60 minutes, and then filtering. The above lacquer tree extract is obtained by adding 800 parts by weight of 95% (v/v) ethanol to 100 parts by weight of lacquer tree, extracting at 70°C for 1 hour, and then filtering. A composition containing musk that has the effect of improving gastritis and liver function.
In Article 1, The above fermented mulberry leaf product is prepared by adding 700 parts by weight of purified water to 100 parts by weight of mulberry leaves, adding 4 parts by weight of mixed bacteria to 100 parts by weight of mulberry leaf extract extracted at 105°C for 4 hours, and fermenting at 20°C for 20 days. The above mixed bacteria comprises 60% by weight of Bacillus subtilis, 20% by weight of Aspergillus oryzae, 15% by weight of lactic acid bacteria, and 5% by weight of yeast, A composition containing musk that has the effect of improving gastritis and liver function.

Description

Composition comprising rat musk having inhibitory effect on alcohol-induced liver damage and gastritis The present invention relates to a composition containing *Seohyang* having an effect of improving gastritis and liver function, and more specifically, to a composition containing *Seohyang* having an effect of improving gastritis and liver function based on *Seohyang*, which exhibits excellent liver function improvement and gastritis inhibition effects and improved suitability for processing as a food. Generally, the liver is a tissue responsible for regulating various biological functions, such as lipid metabolism, nutrient processing, and the supply of energy sources. If liver function deteriorates due to viral infection or cancer, serious abnormalities occur not only in the cardiovascular system but also in nutritional metabolism, thereby impairing overall bodily functions. Recently, the number of patients with so-called adult diseases, such as cardiovascular and metabolic diseases, is rapidly increasing due to causes including environmental pollution, changes in dietary patterns, obesity, and rising psychological stress in social life. In particular, the number of patients suffering from liver-related diseases, such as fatty liver, cirrhosis, liver cancer, or hepatitis, is also on the rise. One of the causes of liver dysfunction is that when severe oxidation occurs in liver tissue, the function of hepatocytes decreases, leading to an overall decline in biological function. For example, consuming large amounts of alcohol reduces the ability to break down alcohol, resulting in a hangover; furthermore, impaired liver function makes one vulnerable to microbial infections, such as viral infections, making one more susceptible to infection; and weakened liver function also leads to an increase in blood cholesterol levels, causing hyperlipidemia. In particular, as physical functions generally decline from adulthood to old age, a decline in liver function makes one susceptible not only to various infections but also to cardiovascular diseases such as heart disease, hyperlipidemia, and hypertension, as well as metabolic diseases like diabetes; therefore, improving liver function is extremely important for maintaining adult health. Korea has one of the highest alcohol consumption rates among OECD countries, and consequently, there is a very high number of patients with alcohol-induced liver disease. Excessive alcohol consumption leads not only to liver disease caused by damage to liver cells but also to damage to the stomach. Therefore, the prevention and treatment of alcohol-induced liver and stomach diseases are critical factors for the health and well-being of the public. Korean Patent Publication No. 10-2023-0057194 (April 28, 2023) discloses a strain of Lactobacillus fermentum and a composition for preventing, improving, or treating alcoholic fatty liver disease containing the same. The above-mentioned composition for preventing alcoholic fatty liver has the advantage of being highly effective in preventing alcoholic fatty liver, but has the disadvantage of being insufficient in improving gastric diseases caused by alcohol. Figure 1 is a graph showing GOT/AST and GPT/ALT values according to the composition of Example 1. Figure 2 is a graph showing gamma-GTP values according to the composition of Example 1. Figure 3 is a graph showing SOD and Catalase levels according to the composition of Example 1. Figure 4 is a graph showing organ weight and body weight according to the composition of Example 1. Figure 5 is a graph showing the gastritis-inhibiting effect according to the composition of Example 1. Figure 6 is a graph showing the antioxidant activity according to the composition of Example 1. The present invention will be described in detail below. First, a composition containing musk having an effect of improving gastritis and liver function according to the present invention will be described. The composition of the present invention containing musk having an effect of improving gastritis and liver function is, It contains 80% by weight of Korean musk, 10% by weight of camellia flower extract, 5% by weight of Polygala tenuifolia extract, 4% by weight of lacquer tree extract, and 1% by weight of fermented Akebia quinata leaf extract. The above-mentioned musk is obtained from musk rats. The pharmacological effects of musk include promoting sweating and diuresis, stimulating the central nervous system, and specifically stimulating the respiratory and cardiac centers to aid in the resuscitation of patients in a state of mental confusion. Furthermore, it is known to exhibit anti-inflammatory and antibacterial effects on early to mid-stage inflammation, as well as effects on the circulatory system, uterine stimulation, anticancer activity, cardiotonic, sedative, respiratory improvement, blood pressure lowering, and anti-stress properties. Musk is an essential ingredient in high-quality herbal medicines and is