KR-102962818-B1 - Microbiome-Friendly Compositions for oral-care

Abstract

The present invention relates to a microbiome-friendly oral care composition, and more specifically, is characterized by including 2,3-butanediol as an active ingredient. According to the microbiome-friendly oral care composition of the present invention, while effectively inhibiting the proliferation of pathogenic bacteria in the oral cavity, it is possible to maintain the growth of oral commensal bacteria to preserve the diversity and balance of the oral microbiome, thereby having the advantage of fundamentally solving the problems of inhibiting beneficial bacteria and imbalance in the oral ecosystem that occur in conventional oral care compositions based on fluoride, ethanol, and cetylpyridinium chloride (CPC).

Inventors

• 정종윤

Assignees

• 주식회사 파마이노베이션

Dates

Publication Date

20260511

Application Date

20251124

Claims (6)

1. It contains 2,3-butanediol as an active ingredient, and A microbiome-friendly oral care composition characterized in that the above 2,3-butanediol is in one or more forms selected from (2R,3R)-2,3-butanediol and (2S,3S)-2,3-butanediol.
2. delete
3. In paragraph 1, The above 2,3-butanediol is based on 100% by weight of the composition, A microbiome-friendly oral care composition characterized by containing 1 to 20 weight percent.
4. In paragraph 1 or 3, Inhibits the growth of one or more of Streptococcus mutans and Porphyromonas gingivalis, and A microbiome-friendly oral care composition characterized by maintaining the growth of Streptococcus mitis and Streptococcus salivarius.
5. In paragraph 1 or 3, A microbiome-friendly oral care composition characterized by additionally including one or more of dental-type silica, sodium fluoride, glycerin, sorbitol, xylitol, sodium carboxymethylcellulose, hydrated silica, sodium cocoyl glutamate, lauroylamidopropyl dimethylglycine solution, green tea extract, carrot extract, myrrh tincture, ratania tincture, chamomile tincture, menthol, Centella asiatica extract, sodium bicarbonate, and fragrance.
6. In paragraph 1 or 3, The above oral care is, A microbiome-friendly oral care composition characterized by including one or more of the following: prevention of gingivitis, prevention of periodontitis, suppression of bad breath, and relief of dry mouth.

Description

Microbiome-Friendly Compositions for Oral Care The present invention relates to an oral care composition, and more specifically, to a microbiome-friendly oral care composition that can prevent and improve oral diseases such as gingivitis, periodontitis, bad breath, and dry mouth by maintaining the balance of the oral microbiome. As population aging accelerates, the importance of oral health care is being recognized more significantly in society. The necessity of oral care is being further emphasized because the elderly are not only more vulnerable to chronic oral diseases such as gingivitis and periodontitis, but their oral health is also closely linked to their overall health. According to recent studies, periodontal disease is highly correlated with major diseases of old age, such as cardiovascular disease, diabetes, respiratory disease, and dementia; therefore, in an aging society, oral health care technology is establishing itself as a crucial factor determining overall public health, extending beyond mere oral hygiene. Over hundreds of different types of bacteria exist in the oral cavity, forming a microbial ecosystem known as the oral microbiome through complex interactions. Under normal conditions, the oral microbiome plays a crucial role in suppressing the development of cavities, gingivitis, and periodontitis, as well as maintaining oral homeostasis. However, when specific pathogenic bacteria become dominant due to factors such as stress, unbalanced dietary habits, or the overuse of antimicrobial agents, the balance of the oral microbiome is disrupted, leading to oral diseases. Oral care products currently on the market are being developed in various formulations such as toothpaste, mouthwash, gargle, and lozenges, and most of these products are based on ingredients such as fluoride, ethanol, and cetylpyridinium chloride (CPC). However, compositions based on these ingredients have several limitations. First, while fluoride is effective in preventing cavities by strengthening tooth enamel, there are concerns regarding side effects such as dental fluorosis due to excessive fluoride intake with long-term use. Second, although ethanol acts as a bacterial inhibitor and solvent, it can irritate the oral mucosa and cause dry mouth; furthermore, some studies have raised concerns regarding carcinogenic risks associated with long-term use. Third, while CPC exhibits strong antibacterial action, it has been reported to inhibit beneficial oral bacteria as well, potentially disrupting the diversity and balance of the oral microbiome in the long term. Particularly for the elderly, long-term use of existing fluoride, ethanol, and CPC-based oral care products may not be suitable due to physiological characteristics such as reduced saliva production, dry mouth, and weakened immunity. In fact, while existing oral care products excel at short-term antibacterial effects, they can actually be detrimental to maintaining long-term oral health. When beneficial bacteria are suppressed, the diversity of the oral microbiome declines, increasing the likelihood of the regrowth of specific harmful bacteria or the development of antibiotic-resistant strains. This can lead to the recurrence of gingivitis and periodontitis, the worsening of dry mouth, and even the systemic spread of oral inflammation. Meanwhile, with the recent active progress of oral microbiome research, there is a growing awareness that maintaining oral microbial balance is more important than simple antimicrobial effects. However, a review of conventional patent literature and commercially available products reveals that most approach this by adding "antimicrobial agents" or "antibiotics," and there are virtually no compositions that consider the balance of the oral microbiome itself. For example, oral compositions containing mulberry bark extract or antibiotics have reported inhibitory effects on pathogenic bacteria, but their impact on beneficial bacteria has been overlooked. Another prior art method treats periodontitis by administering high concentrations of antibiotics, but this can lead to the destruction of the oral ecosystem and the development of antibiotic resistance in the long term. In particular, while periodontitis is closely associated with the proliferation of pathogenic bacteria such as Streptococcus mutans, Porphyromonas gingivalis, and Treponema denticola, the balance of the oral ecosystem is maintained only when commensal bacteria, such as Streptococcus mitis and Streptococcus salivarius, exist at appropriate levels. Existing antimicrobial ingredients have the characteristic of inhibiting both pathogenic and commensal bacteria without distinguishing between them; therefore, although disease improvement may be temporary, they are not suitable for long-term oral health. Therefore, there is an urgent need for a new oral care composition that can inhibit the growth of pathogenic bacteria while preserving oral commensal bacteria—that is, a microbi