KR-102962888-B1 - A Composition Comprising Weissella confusa WIKIM 29 Having Anti-Obesity Effects Against Various Types of Obesity and Antibacterial Effects Against Various Pathogenic Strains

Abstract

The present invention relates to a composition comprising the Weissella confusa WIKIM29 strain, which has excellent acid resistance, bile resistance, intestinal epithelial cell adhesion ability, antibacterial activity such as the ability to inhibit harmful bacteria, and anti-obesity ability such as inhibition of pancreatic lipase activity and inhibition of neutral lipids. Specifically, the invention relates to an antibacterial composition, an anti-obesity food composition, a pharmaceutical composition for treating or preventing obesity, and a feed additive composition containing the Weissella confusa WIKIM29 strain, a culture medium of the strain, a fermented product of the strain, a concentrated product of the culture medium, a dried product of the culture medium, or a combination thereof as active ingredients.

Inventors

• 손은심
• 김욱

Assignees

• 주식회사 요헤벳

Dates

Publication Date

20260512

Application Date

20251222

Priority Date

20250721

Claims (4)

1. A food composition for antibacterial and anti-obesity purposes containing as active ingredients the Weissella confusa WIKIM29 strain deposited under accession number KFCC11638P, a culture medium of said strain, a fermented product of said strain, a concentrate of said culture medium, a dried product of said culture medium, or a combination thereof, The above composition has antimicrobial activity against one or more pathogenic strains selected from the group consisting of Escherichia coli , Salmonella typhimurium , and Bacillus cereus , and The above composition is an antibacterial and anti-obesity food composition characterized by having anti-obesity activity through inhibition of pancreatic lipase enzyme and inhibition of neutral lipid accumulation.
2. In paragraph 1, The above food is a fermented food, and is a food composition for antibacterial and anti-obesity purposes.
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Description

A Composition Comprising Weissella confusa WIKIM 29 Having Anti-Obesity Effects Against Various Types of Obesity and Antibacterial Effects Against Various Pathogenic Strains The present invention relates to a composition comprising the Weissella confusa WIKIM29 strain, which has excellent acid resistance, bile resistance, intestinal epithelial cell adhesion ability, antibacterial activity such as the ability to inhibit harmful bacteria, and anti-obesity ability such as inhibition of pancreatic lipase activity and inhibition of neutral lipids. Specifically, the invention relates to an antibacterial composition, an anti-obesity food composition, a pharmaceutical composition for treating or preventing obesity, and a feed additive composition containing the Weissella confusa WIKIM29 strain, a culture medium of the strain, a fermented product of the strain, a concentrated product of the culture medium, a dried product of the culture medium, or a combination thereof as active ingredients. Lactic acid bacteria are microorganisms that break down sugars to produce lactic acid. They are widely distributed not only in the digestive tracts of humans and animals but also in various foods and natural environments, playing a role in the human digestive tract by breaking down fiber and complex proteins into important nutrients. These beneficial lactic acid bacteria exert various positive effects, such as improving the microbial environment within the gastrointestinal tract of humans and animals and enhancing immunity. Recent research is expanding their scope of application beyond general foods to include health foods and pharmaceuticals. Among lactic acid bacteria, "probiotics" refer to live bacteria that colonize the intestines when consumed in appropriate amounts and perform various functions, such as promoting intestinal health, enhancing immunity, and reducing cholesterol. When probiotics reach the intestines and grow on the intestinal mucosa, they produce lactic acid, changing the intestinal environment to an acidic state. This acidic environment inhibits the proliferation of harmful bacteria and promotes the growth of beneficial bacteria, contributing to the creation of a healthy intestinal environment. Approximately 1 kg of bacteria inhabit the human intestines, and a vast number of microorganisms coexist, with bacteria accounting for about 40% of feces. In particular, more than 90% of the fecal bacteria in healthy breastfed babies consist of Bifidobacterium; however, as one ages, beneficial bacteria decrease while harmful bacteria increase. Probiotics play an important role in helping maintain a healthy distribution of the gut microbiome during this normal aging process. Lactic acid bacteria produce lactic acid by anaerobicly utilizing carbohydrates and play an important role in fermented foods such as kimchi, yogurt, and sauerkraut. Lactic acid bacteria that enter the intestines colonize intestinal epithelial cells, preventing the colonization of harmful microorganisms. By secreting antimicrobial substances, they inhibit the growth of harmful microorganisms and alleviate diarrhea and constipation. Furthermore, they perform functions such as enhancing immune activity, anticancer effects, and lowering serum cholesterol. When added directly or indirectly to food, the metabolites of lactic acid improve food shelf life and enhance flavor and texture. Lactic acid bacteria are a type of probiotic that plays a crucial role in promoting human health by preventing microbial contamination of the enteritis and genitourinary tract, maintaining intestinal health, relieving constipation, inhibiting the proliferation of harmful bacteria, and possessing anticancer, immune-boosting, cholesterol-lowering, conjugated linoleic acid (CLA) production, and suppressing Helicobacter pylori. Microorganisms used as such probiotics must possess characteristics such as resistance to gastric and bile acids, the ability to colonize and proliferate on host small intestinal epithelial cells, and safety. If we discover and utilize lactic acid bacteria with excellent activity that reduces fat absorption through the absorption of beneficial bacteria into the body, we can significantly enhance the functionality of food by creating a healthy dietary environment that improves the intestinal microbial environment and prevents metabolic diseases caused by weight gain. The aforementioned background technology is one that the inventor possessed or acquired in the process of deriving the content of the present disclosure, and it cannot be considered as prior art disclosed to the general public prior to the filing of this application. Figure 1 is a graph showing the results of confirming the acid resistance of the Weissella confus WIKIM29 strain according to one embodiment of the present invention. Figure 2 is a graph showing the results of confirming the bile resistance of the Weissella confus WIKIM29 strain according to one embodiment of the present inventi