KR-102962889-B1 - Cosmetic composition containing herbal complex extract as an active ingredient

Abstract

The present invention relates to a cosmetic composition containing a herb extract as an active ingredient, and more specifically, to the scalp care efficacy of a herb 70% ethanol extract. A cosmetic composition containing a herbal extract according to the present invention as an active ingredient has excellent electron-donating ability and antibacterial activity, has efficacy in proliferating human epidermal cell lines and dermal papilla cell lines, and has excellent efficacy in inhibiting the activity of 5α-reductase, which can prevent hair loss, so it can be used as a cosmetic composition for scalp care.

Inventors

• 김미경

Assignees

• 서원대학교산학협력단

Dates

Publication Date

20260511

Application Date

20240115

Claims (4)

1. The herbal extract contains a 70% (v/v) ethanol extract of herbs, The herbs of the above herbal extract include one or more of henna, cassia, and amla, and The above herbal extract contains polyphenols, electron donating ability and It has antibacterial activity and further includes proliferation activity of HaCaT cells and HDP cells and 5α-reductase inhibitory activity, Compared to the control vitamin C, the henna ethanol extract showed 87.24% electron-donating activity at a concentration of 500 μg /mL, the cassia ethanol extract showed 83.08%, and the amla ethanol extract showed 84.65% at 100 μg /mL. The above amla ethanol extract comprises having a growth inhibition zone of 15.7-25.3 mm against P. acnes strains at a concentration of 1 to 20 mg/ml, and The method is characterized by the fact that, for HaCaT cells, the henna and cassia ethanol extracts increase cell viability by 108.25 to 116.52% and 102.86 to 108.29%, respectively, at a concentration of 5 to 300 ug/mL, and the amla ethanol extract increases cell viability by 102.20 to 110.80% at a concentration of 5 to 100 ug/mL. A cosmetic composition containing herbal extracts as active ingredients, characterized by further including an increase in cell viability for HDP cells at a concentration of 5 to 100 µg/mL, such that the henna ethanol extract increases cell viability by 110.41 to 113.62%, the cassia ethanol extract by 109.13 to 111.58%, and the amla ethanol extract by 102.41 to 111.71%.
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3. In paragraph 1, The above 70% (v/v) ethanol extract of the herb is, A step of washing each of the above herbs and then hot-air drying them at 70°C for 48 hours; A step of crushing the herbs after the above drying step; A step of adding 10 parts by weight of 70% (v/v) ethanol to 1 part by weight of the crushed herbs and stirring at room temperature for 24 hours; and The method includes a step of separating the supernatant and the precipitate through primary filtration using a nonwoven fabric after the above stirring step; A second step of adding 10 parts by weight of 70% (v/v) ethanol based on 1 part by weight of the precipitate obtained from the above stirring step and the step of separating the supernatant and precipitate, and stirring and separating the supernatant and precipitate; and A third step of adding 10 parts by weight of 70% (v/v) ethanol based on 1 part by weight of the precipitate obtained from the second step above, and stirring and separating the supernatant and the precipitate; further comprising A step of secondary filtration of the supernatant obtained from 70% (v/v) ethanol extraction using filter paper and a vacuum pump; A step of concentrating the supernatant of the second filtered liquid using a rotary evaporator under reduced pressure; and A cosmetic composition containing a herb extract as an active ingredient, characterized by further including the step of freeze-drying the concentrate concentrated under reduced pressure as described above.
4. In paragraph 3 Based on 70.92 parts by weight of purified water, containing 3 parts by weight of Innosolve®GG, 2 parts by weight of BH-780, 6 parts by weight of 1,3-Butylene Glycol-P, 0.3 parts by weight of D-panthenol, 3 parts by weight of Innosolve®MPS, 1.5 parts by weight of Rheodol TW-O120V(Tween-80), 0.3 parts by weight of Menthol Crystall (L-Menthol), 0.25 parts by weight of Salicylic Acid, 0.1 parts by weight of Peptide 5 Complex, 0.4 parts by weight of Henna ethanol extract, 0.2 parts by weight of Amla ethanol extract, 0.4 parts by weight of Cassia ethanol extract, 5 parts by weight of 70% (v/v) ethanol, 0.3 parts by weight of L-Arginine, 1 part by weight of Rosemary Essential oil, and 5.33 parts by weight of Rheodol TW-O120V(Tween-80). It further includes a step of completing a cosmetic composition to complete a liquid cosmetic composition, and The above Innosolve®GG is composed of 70-90wt% Glyceryl Glucoside, 5-15wt% Glycerin, and 5-15wt% Water, BH-780 is 1,2-Hexanediol, Butylene Glycol-P has a molecular formula C₄H₁₀O₂ , Innosolve®MPS is 2-Methyl- 1,3 -Propanediol, and Peptide 5 Complex contains 0.1ppm of sh-Oligopeptide-1, 0.1ppm of sh-Polypeptide-1, 0.1ppm of sh-Polypeptide-3, 5ppm of Acetyl Hexapeptide-8, 5ppm of Copper Tripeptide-1, and 0.30wt% 1,2-Hexanediol based on 100wt% Water. A cosmetic composition containing a herbal extract as an active ingredient, characterized by containing 0.30 wt% of Caprylyl Glycol.

Description

Cosmetic composition containing herbal complex extract as an active ingredient The present invention relates to a cosmetic composition containing a herb extract as an active ingredient, and more specifically, to the scalp care efficacy of a herb 70% ethanol extract. In addition to its roles of blocking ultraviolet rays and protecting the scalp from external stimuli, hair plays a cosmetic role and acts as a crucial factor in quality of life. When hair loss is defined as the shedding of hair due to abnormal causes in its development and growth, it leads to depression, lowered self-esteem, and negative impacts on social interactions. With the number of hair loss patients in Korea exceeding 230,000 in 2015, the hair loss-related market has reached approximately 4 trillion won, making hair loss a significant social issue. Hair loss progresses due to various causes such as genetics, irregular eating habits, nutritional imbalances, aging, male hormones, and stress, leading to miniaturization where hair becomes thin and weak, an increase in resting hair preparing for shedding, and loss of hair follicle function. In cases of seborrheic scalp, which is common among modern people characterized by excessive sebum secretion from the scalp's sebaceous glands, seborrheic alopecia may occur due to the irritation caused by the breakdown products of the sebum by resident scalp bacteria. Stress affects the autonomic nervous system, and capillaries may expand or contract under the influence of the autonomic nervous system. The sympathetic nervous system, which is overactive due to stress, constricts capillaries, weakening the supply of nutrients to the hair and skin, thereby shortening the hair growth phase and leading to hair loss. Research is actively underway to inhibit or improve the progression of hair loss. While oral finasteride and topical minoxidil are currently the representative FDA-approved hair loss treatments, their therapeutic effects are temporary and they cause various side effects with continuous use; consequently, active research is being conducted in the hair loss treatment market to find alternatives. Currently, finasteride, a 5α-reductase inhibitor, is the most widely prescribed treatment for androgenetic alopecia, but side effects such as male sexual dysfunction, decreased sperm count, birth defects, and gynecomastia in men have been reported, and minoxidil has been reported to have side effects such as scalp dryness, itching, erythema, and hirsutism. Therefore, there is a need for natural-derived hair loss treatments and cosmetic compositions for scalp care that do not cause such side effects. Meanwhile, henna (Lawsonia inermis) is a plant belonging to the Lythraceae family; the extract is made by picking, drying, and grinding the leaves into a powder, and for centuries, it has been used in Islamic and Hindu cultures as a pigment to dye hair, decorate nails, or for temporary skin tattoos. Cassia (Cassia obovata) helps repair damaged hair and add shine due to the anthraquinones and specific chrysophamic acid components contained in its leaves, while Amla (Phyllanthus emblica L) is used in the form of food or health supplements not only in India but also in many countries such as the United States, the United Kingdom, and China. FIG. 1 is a graph briefly illustrating the electron-donating capacity of a cosmetic composition containing a herbal extract as an active ingredient according to an embodiment of the present invention. The data were measured three times under the same conditions and are expressed as the mean and standard deviation (means ± standard deviation, SD). In addition, the significance of the results was tested using SPSS Statistics 23 with a t-test to determine the significance values (*p<0.05, **p<0.01, ***p<0.001). The significance test was performed by analyzing the results using analysis of variance (ANOVA) and then testing at the p<0.05 level using Duncan's multiple range test. The statistical processing is the same as described below, and Vitamin C is the control group. FIG. 2 is a graph briefly illustrating the antibacterial activity of henna, cassia, and amla ethanol extracts against skin commensal bacteria of a cosmetic composition containing herbal extracts as active ingredients according to an embodiment of the present invention. FIG. 3 is a graph briefly illustrating the effect of henna, cassia, and amla ethanol extracts of a cosmetic composition containing herbal extracts as active ingredients according to an embodiment of the present invention on the proliferation of HaCaT cells. Figure 4 is a graph showing the effect of henna, cassia, and amla ethanol extracts on the proliferation of hair papilla cells in a cosmetic composition containing herbal hot water extracts as active ingredients according to an embodiment of the present invention. FIG. 5 is a graph showing the toxicity of henna, cassia, and amla ethanol extracts to hair papilla cells in a cosmetic composition containi