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KR-102963145-B1 - Integrated Sensor Assembly Unit

KR102963145B1KR 102963145 B1KR102963145 B1KR 102963145B1KR-102963145-B1

Abstract

A sensor assembly comprising a first substrate, a second substrate, and a sensor. The first substrate includes at least one plurality of capillary holes defining a fluid path. The fluid path extends through the first substrate to a fluid channel from the upper side of the first substrate to the lower side. The second substrate is disposed in connection with the first substrate, and the fluid channel of the first substrate is in fluid communication with a first metallized via and a second metallized via formed in the second substrate. By this, the fluid path extends through the first metallized via and the second metallized via. The sensor includes a first electrode and a second electrode. The first electrode and the second electrode are disposed on the second substrate that is in fluid communication with the fluid channel of the first substrate. The first electrode is electrically in contact with the first metallized via, and the second electrode is electrically in contact with the second metallized via.

Inventors

  • 랑스텐, 펠레
  • 렌룬드, 마르쿠스

Assignees

  • 아스실리온 에이비

Dates

Publication Date
20260508
Application Date
20200617
Priority Date
20190712

Claims (14)

  1. A first substrate (110, 210, 310, 410, 610, 810) comprising at least one capillary hole (111, 211, 311, 411, 511) defining a fluid path (112, 412, 812), said fluid path extends through the first substrate from an upper side (113, 313, 413, 813) of the first substrate to a fluid channel (114, 214, 414, 814) on a lower side (115, 215, 415, 815); A second substrate (120, 220, 320, 420, 620, 720, 820) disposed connected to the first substrate, wherein the fluid channel of the first substrate is in fluid communication with a first metallized via (121, 221, 421, 621, 721, 821) and a second metallized via (122, 222, 422, 622, 722, 822) formed on the second substrate, and the fluid path is extended through the first metallized via and the second metallized via; A sensor (130, 230, 430, 830) comprising a first electrode (231, 731) and a second electrode (232, 732) disposed on the second substrate to be in fluid communication with the fluid channel of the first substrate; and A sensor assembly (100, 200, 300, 400, 800), wherein the first electrode is electrically in contact with the first metallized via and the second electrode is electrically in contact with the second metallized via.
  2. In paragraph 1, The first substrate above is a sensor assembly comprising a plurality of holes.
  3. In paragraph 1 or 2, A sensor assembly further comprising means for applying negative pressure to the fluid path to draw fluid from the capillary holes toward the second substrate.
  4. In paragraph 1 or 2, It further includes a plurality of micro-needles integrally formed on the first substrate, and Each microneedle is, It includes an elongated body extending from a distal end to a proximal end having a bevel along a longitudinal axis on the first substrate, and The above capillary holes extend longitudinally through the above elongated body and further define the above fluid path; A sensor assembly in which the proximal end is integrally formed with the first substrate and the fluid path is fluidly in communication with the fluid channel of the first substrate.
  5. In paragraph 4, A sensor assembly wherein the second substrate is connected to the first substrate and disposed on the side facing the plurality of micro-needles.
  6. In paragraph 1 or 2, A sensor assembly in which the first electrode is spiral-shaped, the second electrode is spiral-shaped, and the spiral shapes of the first and second electrodes are nested.
  7. In paragraph 1 or 2, The sensor assembly is positioned on one side of the second substrate facing the first substrate.
  8. In paragraph 1 or 2, The sensor assembly is positioned at least partially on one side of the second substrate facing the first substrate.
  9. In paragraph 1 or 2, The sensor assembly is at least partially located in the first and second vias.
  10. In paragraph 1 or 2, A sensor assembly, wherein the via further includes a signal path extending through the second substrate, and the sensor is positioned to be electrically connected to the signal path.
  11. In paragraph 1 or 2, A sensor assembly in which the via is hollow, thereby providing fluid communication between two opposing sides of the second substrate.
  12. In paragraph 1 or 2, The above sensor is a sensor assembly that is an electrochemical sensor.
  13. In paragraph 1 or 2, A sensor assembly in which the walls of the above vias are hydrophilic.
  14. A measuring device comprising a sensor assembly according to paragraph 1 or 2, A measuring device further comprising a negative pressure device disposed in connection with a sensor assembly opposite to at least one microneedle and fluidly communicating with the via of the second substrate, thereby providing negative pressure through the via of the sensor assembly and the fluid channel.

Description

Integrated Sensor Assembly Unit The present invention generally relates to a sensor assembly for sampling body fluids. The present invention particularly relates to a sensor assembly provided on a first substrate having at least one capillary hole and a second substrate having two metallized vias and a sensor. The present invention also relates to a sensor assembly in which the first substrate has a plurality of microneedles and the capillary holes extend through the plurality of microneedles. For example, there are various methods for sampling body fluids using syringes. This is cumbersome, and improved alternatives exist, such as the use of microneedles. While there are many applications for microneedles, the majority of disclosed microneedles relate to various forms of drug delivery. For example, the concept of an array of small needles for drug delivery dates back to the 1970s with US 3,964,482. One of the first microneedles reported in the scientific literature was "A silicon-based, three-dimensional neural interface: manufacturing processes for an intercortical electrode array.", IEEE Trans Biomed Eng. 1991 Aug; 38(8):758-68, Campbell et al. Eventually, biosensing technology will reach the 21st century just as microelectronics did in the late 20th century. Integrated circuits (ICs) have had a tremendous impact on our daily lives today, and leveraging the miniaturization and cost advantages of mass-manufactured biosensing enables clinical diagnostics and health monitoring to move from expensive laboratories to small, portable consumer devices. Sampling the analyte to be measured is a prerequisite for biosensing. Many designs described in scientific papers are intended to extract body fluids, such as blood or interstitial fluid (ISF). Different body fluids require different solutions. For example, while it has been proven that blood can be successfully extracted using natural "overpressure" in vascular systems, successful extraction of ISF without "underpressure" via other mechanisms, such as diffusion or capillary forces, is rare or non-existent. In this specification, the terms "underpressure" and "subpressure" are used interchangeably. Regardless of the sampling method, the sample must be transferred to the sensing device in a controlled manner. To further improve usability and prevent errors, this can preferably be performed in an integrated unit. The object of the present invention is to provide an improved solution for body fluid sampling, setting aside the aforementioned disadvantages of previously known sensor assemblies. Low pressure can be applied to improve fluid extraction, such as with ISF. However, this is difficult to combine with collecting readings from an integrated sensor. It was realized that a fluid path extending through the sensor assembly is advantageous. Additionally, to have an operating sensor, the included electrodes need to be connected to and communicate with external components of the sensor assembly. The object of the present invention is to provide an improved sensor assembly having a fluid path extending through an integrated operating sensor and assembly that allows for easy sampling of body fluids such as interstitial fluid (ISF). The object of the present invention is satisfied in a sensor assembly as defined in the appended claims. In a first aspect, the present invention relates to a sensor assembly comprising a first substrate, a second substrate, and a sensor. The first substrate includes at least one capillary bore defining a fluid path. The fluid path extends through the first substrate to a fluid channel from the upper side of the first substrate to the lower side. The second substrate is disposed in connection with the first substrate, and the fluid channel of the first substrate is in fluid communication with a first metallized via and a second metallized via formed in the second substrate. By this, the fluid path extends through the first metallized via and the second metallized via. The sensor comprises a first electrode and a second electrode. The first electrode and the second electrode are disposed on the second substrate in fluid communication with the fluid channel of the first substrate. The first electrode is electrically in contact with the first metallized via, and the second electrode is electrically in contact with the second metallized via. In the embodiments, the first substrate may include a plurality of bore holes. In the embodiments, the sensor assembly may further include means for applying sub-pressure to the fluid path to draw fluid from the capillary bore holes toward the second substrate. In the embodiments, the sensor assembly may further include a plurality of microneedles integrally formed on the first substrate. Each microneedle may include an elongated body extending from a distal end to a proximal end on the first substrate along a longitudinal axis. Each microneedle may further have a bevel at the distal end. A capillary bore ma