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KR-102963371-B1 - TEMPERATURE SENSITIVE POLYMER COMPOSITION, POLYMER GEL COMPOSITE, MEDICAL ARTICLES AND COSMETIC ARTICLES USING THE SAME

KR102963371B1KR 102963371 B1KR102963371 B1KR 102963371B1KR-102963371-B1

Abstract

The present invention relates to a temperature-sensitive polymer composition having a specific matrix that can increase the delivery efficiency of an active substance through a phase transition caused by body temperature upon contact with the skin, and improve the stability of the active substance even when manufacturing and using a transdermal patch, as well as to a polymer gel composite, medical supplies, and cosmetic supplies using the same.

Inventors

  • 김윤섭
  • 김찬중
  • 김지선
  • 한혜진

Assignees

  • 주식회사 엘지화학

Dates

Publication Date
20260508
Application Date
20200525

Claims (17)

  1. It comprises a matrix composed of a biocompatible polymer and water, and The weight-average molecular weight of the above biocompatible polymer is 100,000 g/mol or more, and With respect to 100 parts by weight of the above water, the content of the biocompatible polymer is 10 parts by weight or more and 20 parts by weight or less, and The above-mentioned biocompatible polymer is gelatin, and The apparent viscosity of the above matrix measured at 4°C is 975 Pa·s or higher and 3353 Pa·s or lower, and A temperature-sensitive polymer composition having a Young's modulus of 60 kPa or more and 70 kPa or less, measured at 4 ℃ of the above matrix.
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  3. In paragraph 1, A temperature-sensitive polymer composition having an apparent viscosity of 0.10 Pa·s or more and 0.12 Pa·s or less, measured at 32°C of the above matrix.
  4. In paragraph 1, A temperature-sensitive polymer composition in which the gelation start temperature of the matrix is 0°C or higher and less than 40°C when the temperature is reduced at a rate of 5°C/min starting from 40°C.
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  10. In paragraph 1, The above biocompatible polymer is a temperature-sensitive polymer composition having a sol-gel phase transition temperature of 0°C or higher and less than 40°C.
  11. In paragraph 1, A temperature-sensitive polymer composition further comprising an active material dispersed in the above matrix.
  12. In Paragraph 11, The above active material is a temperature-sensitive polymer composition comprising a pharmaceutical active material or a cosmetic active material.
  13. A polymer gel composite comprising a gel of the temperature-sensitive polymer composition of claim 1.
  14. A medical device comprising the polymer gel complex of claim 13.
  15. In Paragraph 14, A medical product comprising a support, and a transdermal patch formed on the support and comprising a pharmaceutically active substance delivery layer including the polymer gel complex.
  16. A cosmetic product comprising the polymer gel complex of claim 13.
  17. In Paragraph 16, A beauty product comprising a support, and a beauty pack formed on the support and comprising a beauty-active substance delivery layer including the polymer gel complex.

Description

Temperature-sensitive polymer composition and polymer gel composite using the same, medical and cosmetic articles The present invention relates to a temperature-sensitive polymer composition that increases the delivery efficiency of active ingredients through a sol-gel phase transition caused by body temperature upon contact with the skin, and ensures the stability of active ingredients even when manufacturing and using a transdermal patch, as well as to a polymer gel composite, medical supplies, and cosmetic supplies using the same. As a method for the effective delivery of drugs applied to the human body, the method of injecting drugs in liquid form through a subcutaneous injection needle is widely used. However, subcutaneous injection needles with a diameter of several millimeters can stimulate numerous pain points in the skin, causing pain to the patient, and there is a problem in that their use requires a high level of skill. Recently, to overcome the aforementioned disadvantages of subcutaneous injection needles, transdermal drug delivery methods utilizing micro-needle devices with diameters and heights of only tens or hundreds of micrometers are being actively researched. Micro-needle devices perforate the stratum corneum, the primary barrier layer for transdermal drug delivery, using micro-needles to simultaneously form numerous micro-channels. Through these micro-channels, a sufficient amount of drug can reach the epidermal or dermal layer of the skin, and subsequently, is absorbed via blood vessels and lymphatic vessels to enter the body's circulatory system. As another application, the micro-needles are also used for cosmetic purposes. For example, there is a method in which the bioactive substance is applied to the skin or the micro-needles, and then micro-channels are formed in the skin by the micro-needles to deliver the active substance into the skin. As another example, the bioactive substance for cosmetic purposes may be contained in the micro-needles so that the bioactive substance is supplied into the human skin or circulatory system simultaneously with the insertion of the micro-needles into the skin. While the aforementioned transdermal delivery method of the active substance is useful in terms of user convenience, for its application, it is desirable to utilize a patch type that simplifies the conventional micro-needle device with a complex structure. Generally, microneedle patches contain a liquid or solid biocompatible material containing an active substance as a matrix, and various studies are being conducted to efficiently deliver the active substance dispersed in this matrix transdermally. In addition to microneedles, various methods are being attempted to increase drug penetration into the skin, each involving the use of either physical or chemical penetration enhancement. Physical methods for enhancing skin penetration include, for example, electrophoresis techniques involving ion introduction and ultrasound techniques. Additionally, lasers, radiofrequency currents, or sparks are used to exfoliate the stratum corneum and form microchannels, through which drug molecules can diffuse into the epithelium or dermis. Chemical enhancement is generally achieved by compounds administered alongside the drug to increase permeability to the stratum corneum, thereby providing enhanced drug penetration through the skin. The invention is described in more detail in the following examples. However, the following examples are merely illustrative of the invention, and the scope of the invention is not limited by the following examples. <Example: Preparation of a temperature-sensitive polymer composition and a composition for a transdermal patch> Reference Example 1 A temperature-sensitive polymer composition in the form of a sol was prepared by stirring 5 mg of gelatin with a weight-average molecular weight of 186,000 g/mol and 200 mg of distilled water at 50 ℃ for 1 hour. A composition for a transdermal patch for in vitro release evaluation was prepared by dissolving 0.266 mg of human growth hormone (hGH) in the above-mentioned sol-type temperature-sensitive polymer composition. Reference Example 2 A temperature-sensitive polymer composition was prepared in the same manner as in Reference Example 1, except that the content of the gelatin was changed to 10 mg. A composition for a transdermal patch for evaluating in vivo and ex vivo release was prepared by dissolving 1 mg of human growth hormone (hGH) in the above-mentioned sol-type temperature-sensitive polymer composition. Reference Example 3 A temperature-sensitive polymer composition and a composition for a transdermal patch were prepared in the same manner as in Reference Example 2 above, except that 2.5 mg of human growth hormone (hGH) was dissolved. Example 4 A temperature-sensitive polymer composition and a composition for a transdermal patch were prepared in the same manner as in Reference Example 1, except that the gelatin content was ch