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KR-102963438-B1 - COMPOSITION FOR IMPROVING METABOLIC DISEASES comprising PLANT COLLAGEN PEPTIDES DERIVED FROM CANOLA

KR102963438B1KR 102963438 B1KR102963438 B1KR 102963438B1KR-102963438-B1

Abstract

The present invention provides a composition for improving metabolic diseases comprising 1,000 to 15,000 parts by weight of phyto collagen peptide, 30 to 1,000 parts by weight of vitamin C, 0.09 to 0.9 parts by weight of biotin, and 1 to 15 parts by weight of iron.

Inventors

  • 최문범
  • 윤지숙
  • 이인일
  • 장부식

Assignees

  • 주식회사 리앤씨바이오

Dates

Publication Date
20260512
Application Date
20230113

Claims (5)

  1. It comprises 12,000 parts by weight of phyto collagen peptide, 30 parts by weight of vitamin C, 0.2 parts by weight of biotin, and 2 parts by weight of iron lactate, The above phyto collagen peptide is, A step of pressing canola seeds at a low temperature using an oil press to produce canola wheat in which 50% to 60% of the canola oil contained in the canola seeds is removed; and A first hydrolysis step of producing phyto-precollagen peptides of 1,000 to 3,000 daltons by treating an aqueous canola wheat solution with pH 5 to pH 6 with papain enzyme at 40 to 50°C for 11 to 13 hours, and A filtration step in which the aqueous canola wheat solution hydrolyzed in the first hydrolysis step is filtered through a 75㎛ sieve to remove raw material residue, and the aqueous canola wheat solution from which the raw material residue has been removed is filtered through a 10㎛ filter; An enzyme inactivation step in which the canola wheat aqueous solution filtered in the above filtration step is heated to 85°C for 2 hours to inactivate the enzyme, and A food composition for inhibiting weight gain and reducing systolic blood pressure, characterized by being produced by a method for producing phyto-collagen peptides comprising a second hydrolysis step of adding sodium bicarbonate to the canola wheat aqueous solution inactivated in the enzyme inactivation step to make the pH 6 to 7, adding Alcalase, and then heating at 40°C to 50°C for 2 hours to produce phyto-collagen peptides of 100 Daltons to 500 Daltons.
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  4. In claim 1, A food composition for inhibiting weight gain and reducing systolic blood pressure, further comprising elastin peptide, citric acid, berry concentrate, pomegranate concentrate, red beet concentrate, and grape seed extract.
  5. In claim 4, A food composition for inhibiting weight gain and reducing systolic blood pressure, characterized in that the above berry concentrate is one or more selected from blackberry, blackcurrant, blueberry, strawberry, raspberry, cranberry, black elderberry, aronia, acai berry, dark sweet cherry, and bilberry.

Description

Composition for improving metabolic diseases comprising plant collagen peptides derived from canola The present invention relates to a composition for improving metabolic diseases comprising canola-derived plant collagen peptides, and specifically, to a composition for improving metabolic diseases such as abdominal obesity, hypertension, diabetes, and hyperlipidemia. Metabolic syndrome is on the rise recently due to the Westernization of dietary habits, reduced physical activity, lack of exercise, or stress. Metabolic syndrome refers to a metabolic disorder characterized by increased body fat (obesity), elevated blood pressure (hypertension), elevated blood sugar, and dyslipidemia, which increase the risk of cardiovascular disease, cerebrovascular disease, or diabetes; it is also called a lifestyle disease because it is a disease caused by changes in lifestyle habits. Specifically, metabolic syndrome is accompanied by abdominal obesity, high blood pressure, diabetes, hyperlipidemia, arteriosclerosis, etc. Obesity refers to a condition or disease characterized by excessive body fat due to an energy imbalance. Although the exact cause of obesity has not been clearly identified, it is generally recognized as excess body weight, a biological phenomenon resulting from the interaction of complex genetic, metabolic, environmental, and behavioral factors. Hypertension is a condition in which arterial blood pressure is chronically high, and in adults aged 18 or older, it refers to cases where systolic blood pressure is 140 mmHg or higher or diastolic blood pressure is 90 mmHg or higher, and it may also be caused by obesity, etc. Diabetes mellitus refers to a disease that occurs when the secretion of insulin is insufficient or when the action and function of insulin are not fully performed. Hyperlipidemia is a disease caused by an excessive amount of fat in the blood due to improper lipid metabolism, such as the breakdown of triglycerides and cholesterol. Arteriosclerosis refers to a condition in which fatty substances (plaque) containing cholesterol, phospholipids, calcium, etc., accumulate in the inner lining of blood vessels, causing the arteries to harden, lose elasticity, and narrow, thereby hindering blood supply or increasing pressure, which leads to rupture or dissection of the arteries. According to the results of the 2018 National Health Screening for health insurance beneficiaries, 30% of the Korean population had metabolic syndrome. Risk factors for metabolic syndrome included abdominal obesity (26.6%), hypertension (49.2%), diabetes (42.9%), hypertriglyceridemia (35.4%), and low HDL cholesterol (24.8%). Since hypertension is difficult to cure once it develops, it is important to maintain normal blood pressure by improving dietary and lifestyle habits. Meanwhile, canola seeds contain about 40% lipids and 17% to 26% protein, and canola meal, which is a byproduct of extracting canola oil from canola seeds, contains 44% to 50% protein based on dry weight. Canola meal (de-oiled rapeseed), which remains after pressing canola oil from canola seeds, has primarily been used as animal feed; however, since canola meal has a high protein value, it can also be a good source of protein for humans. And the cell walls of plants contain 1% to 10% of glycoproteins containing a high proportion of hydroxyproline. Glycoproteins play a role in mediating interactions between cells and maintaining structural rigidity. These glycoproteins are rich in glycine, proline, and hydroxyproline, so they are called glycine-rich proteins or hydroxyproline-rich glycoproteins, or they are called phytocollagens because they are structurally similar to animal collagen. Plant-based collagen peptides are also called phyto-precollagen peptides to distinguish them from animal-based collagen peptides and to clearly identify their function of promoting collagen biosynthesis. Phyto-precollagen peptides exist in the form of glycoproteins and are rich in antioxidant substances, such as polyphenol components like tannins. The phenolic compound most abundantly contained in phyto-precollagen peptides is a sinapic acid derivative, which possesses inhibitory activity against angiotensin-converting enzyme (ACE) and antioxidant activity. In addition, small amounts of phenolic compounds are also found in phyto-pre-collagen peptides, such as ferulic acid, which has antioxidant, blood sugar-lowering, and cholesterol-lowering effects; caffeic acid, which has antioxidant and anticancer effects; and chlorogenic acid, which has cholesterol biosynthesis inhibition and lipid peroxidation inhibition effects. Phyto-precollagen peptide inhibits collagen degradation by inhibiting the activity of collagen-degrading enzymes MMP-1 (matrix metalloproteinase-1) and MMP-12 (matrix metalloproteinase-12), and promotes the production of type 1 collagen by promoting the synthesis of procollagen. Phyto-precollagen peptide inhibits the expression of elastin-degrading enzymes and pro