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KR-102963480-B1 - COMPOSITION FOR ANTIBACTERIAL AND ANTI-INFLAMMATORY COMPRISING EXTRACT OF COASTAL HOGFENNEL, AND COMPOSITION FOR PREVENTING OR IMPROVING ASTHMA, ECZEMA AND RHINITIS COMPRISING THE SAME

KR102963480B1KR 102963480 B1KR102963480 B1KR 102963480B1KR-102963480-B1

Abstract

The present invention relates to an antibacterial and anti-inflammatory composition comprising sea aster extract and a composition for the prevention or improvement of asthma, eczema, and rhinitis comprising the same. A composition according to one embodiment of the present invention exhibits excellent antibacterial and anti-inflammatory effects and has no side effects. In addition, the present invention provides various formulations of food compositions and other external agents for preventing or improving allergic and seasonal diseases, including asthma, eczema, and rhinitis.

Inventors

  • 박충무
  • 윤현서
  • 정원정

Assignees

  • 동의대학교 산학협력단

Dates

Publication Date
20260512
Application Date
20220805

Claims (7)

  1. Includes sea aster extract, Korean daisy extract, tangerine peel extract, Commelina extract, Veronica persica extract, and Nasturtium extract. Antibacterial and anti-allergic composition.
  2. In Article 1, The above extract is extracted using an extraction solvent selected from the group consisting of water, alcohols having 1 to 6 carbon atoms, and mixtures thereof. Antibacterial and anti-allergic composition.
  3. delete
  4. A composition according to claim 1 Functional food for antibacterial and anti-allergic purposes.
  5. A composition according to claim 1 Topical skin preparations for antibacterial and anti-allergic purposes.
  6. delete
  7. Includes sea aster extract, Korean daisy extract, tangerine peel extract, Commelina extract, Veronica persica extract, and Nasturtium extract. Composition for the prevention or improvement of asthma, eczema, and rhinitis.

Description

Composition for antibacterial and anti-inflammatory purposes comprising Coastal Hogfennel extract, and composition for preventing or improving asthma, eczema, and rhinitis comprising the same The present invention relates to an antibacterial and anti-inflammatory composition comprising an extract of *Glechoma longifolia* and a composition for the prevention or improvement of asthma, eczema, and rhinitis comprising the same. More specifically, the present invention can provide food compositions and other external agents of various formulations that exhibit excellent antibacterial and anti-inflammatory effects and prevent or improve allergic and seasonal diseases including asthma, eczema, and rhinitis. Allergy generally refers to a phenomenon in which a reaction caused by an immunological mechanism via an allergen—a foreign substance—causes harmful damage to the body. These allergic reactions occur via mast cells, which are widely distributed in organs throughout the body, including the skin, respiratory and gastrointestinal mucosa, perilymphatic vessels, perivascular vessels, and the brain, and are known as the causative cells of allergic reactions. Allergic reactions are caused by IgE, produced to counteract allergens such as house dust mites, pollen, animal dander, mold, ovalbumin, milk protein, and peanuts, acting on mast cells (Wills-Karp M., et al., Science, 282, pp 2258-61, 1998; Grunig G., et al., Science, 282, pp 2261-2263, 1998). To examine this in detail, when an allergen invades the body, it is first recognized by antigen-presenting cells. These antigen-presenting cells then differentiate Th0 cells into Th2 cells by presenting the allergen in the presence of IL-4. These differentiated Th2 cells secrete cytokines such as IL-4, IL-5, and IL-13, which act on B cells to induce the production of IgE. The IgE generated in this way binds to FcεRⅠ, a high-affinity IgE receptor on mast cells. Subsequently, upon re-exposure to the same allergen, the allergen binds to the IgE bound to FcεRⅠ on the mast cells, causing cross-linking between these receptors. This acts as a signal, initiating a series of signal transduction reactions. Through this signal transduction response, degranulation of mast cells is induced, releasing histamine, heparin, bradykinin, triptase, chymase, etc., while leukotrienes and prostaglandins, which are metabolites of arachidonic acid, are newly synthesized and released from cell membrane phospholipids. These substances cause a series of allergic reactions, such as vasodilation, increased permeability, stimulation of nerve endings, increased mucus secretion, and contraction of smooth muscle. As allergic reactions are caused by the degranulation of mast cells, substances that inhibit the degranulation of mast cells have potential as treatments for allergic diseases (Choi, Seon-Pil et al., J. Korean Soc. Appl. Biol. Chem. 48(4), 315-321 (2005)). Meanwhile, Staphylococcus aureus and Staphylococcus epidermidis are commensal bacteria of the skin and, along with Streptococcus pyogenes, are representative strains that can cause purulent infections, cellulitis, or general inflammation of the skin. Although antimicrobial agents such as tetracycline, erythromycin, and azelaic acid are used for these skin infections, side effects such as the emergence of resistant strains, human toxicity including skin hypersensitivity reactions, and photosensitivity have been reported; consequently, research on antimicrobial agents utilizing natural products has been actively conducted recently. Therefore, there is a need for a composition that can be used for a long period without side effects as a natural product-based antimicrobial agent. Meanwhile, some of the substances that play a crucial role in maintaining homeostasis in living organisms are physiologically active substances derived from various organisms. Extensive research has been conducted on numerous physiologically active substances to date, and among them, research on antimicrobial substances isolated from microorganisms, plants, or animals can be considered a very important area in the fields of life science and medicine. It is known that all living organisms produce antimicrobial and antifungal substances for survival. Much research is being conducted on microorganisms that produce these substances, and studies to develop antimicrobial or antifungal agents using these microorganisms or substances isolated from them have been attempted for a long time. Antimicrobial substances are substances that kill microorganisms while having low toxicity to humans or animals and possessing selective toxicity that is not inactivated by enzymes in the body. These substances exert their effects primarily through a mechanism that inhibits the proliferation of microorganisms by inhibiting DNA replication, transcription and decoding of genetic information, transport of electron energy, and biosynthesis of the cell wall. The main antimicrobial substances developed t